Organochlorine compounds and testicular dysgenesis syndrome: Human data

International Journal of Andrology

Volumn 34, Issue 4 PART 2, 2011, Pages

  Cook, M B ^a   Trabert, B ^a   Mcglynn, K A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chlorinated hydrocarbons; Cryptorchidism; Hypospadias; Infertility; Review; Testicular neoplasms

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORPHENOTANE; ENDOCRINE DISRUPTOR; HEXACHLOROCYCLOPENTADIENE; NONACHLOR; ORGANOCHLORINE DERIVATIVE; POLYCHLORINATED BIPHENYL;

CLINICAL ASSESSMENT; CRYPTORCHISM; ENVIRONMENTAL EXPOSURE; GERM CELL TUMOR; HUMAN; HYPOSPADIAS; MALE; MALE FERTILITY; MALE INFERTILITY; PRIORITY JOURNAL; REVIEW; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON MOTILITY; TESTIS DISEASE; TESTIS DYSGENESIS SYNDROME;

ENVIRONMENTAL EXPOSURE; FERTILITY; GONADAL DYSGENESIS; HUMANS; HYDROCARBONS, CHLORINATED; MALE; TESTIS;

EID: 79960864497     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01171.x     Document Type: Review

References (83)

1. Akre O & Richiardi L. (2009) Does a testicular dysgenesis syndrome exist? Hum Reprod 24, 2053-2060.
2. Aneck-Hahn NH, Schulenburg GW, Bornman MS, Farias P & de Jager C. (2007) Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa. J Androl 28, 423-434.
3. Ayotte P, Giroux S, Dewailly E, Hernandez AM, Farias P, Danis R & Villanueva DC. (2001) DDT spraying for malaria control and reproductive function in Mexican men. Epidemiology 12, 366-367.
4. Bennett GW, Ballee DL, Hall RC, Fahey JE, Butts WL & Osmun JV. (1974) Persistence and distribution of chlordane and dieldrin applied as termiticides. Bull Environ Contam Toxicol 11, 64-69.
5. Bhatia R, Shiau R, Petreas M, Weintraub JM, Farhang L & Eskenazi B. (2005) Organochlorine pesticides and male genital anomalies in the child health and development studies. Environ Health Perspect 113, 220-224.
6. Biggs ML, Davis MD, Eaton DL, Weiss NS, Barr DB, Doody DR, Fish S, Needham LL, Chen C & Schwartz SM. (2008) Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 17, 2012-2018.
7. Bray F, Ferlay J, Devesa SS, McGlynn KA & Moller H. (2006a) Interpreting the international trends in testicular seminoma and nonseminoma incidence. Nat Clin Pract Urol 3, 532-543.
8. Bray F, Richiardi L, Ekbom A, Pukkala E, Cuninkova M & Moller H. (2006b) Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality. Int J Cancer 118, 3099-3111.
9. Brucker-Davis F, Wagner-Mahler K, Delattre I, Ducot B, Ferrari P, Bongain A, Kurzenne JY, Mas JC & Fenichel P. (2008) Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations. Hum Reprod 23, 1708-1718.
10. Carlsen E, Giwercman A, Keiding N & Skakkebaek NE. (1992) Evidence for decreasing quality of semen during past 50years. BMJ 305, 609-613.
11. Carmichael SL, Herring AH, Sjodin A, Jones R, Needham L, Ma C, Ding K & Shaw GM. (2010) Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples. Chemosphere 80, 641-646.
12. Charlier CJ & Foidart JM. (2005) Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: lack of relationship to infertility, but evidence of high exposure of the mothers. Reprod Toxicol 20, 215-220.
13. Chia VM, Quraishi SM, Devesa SS, Purdue MP, Cook MB & McGlynn KA. (2010) International trends of testis cancer incidence, overall and by histology, 1973-2002. Cancer Epidemiol Biomarkers Prev 19, 1151-1159.
14. Cohn BA, Cirillo PM & Christianson RE. (2010) Prenatal DDT Exposure and Testicular Cancer: a nested case-control study. Arch Environ Occup Health 65, 127-134.
15. Cook MB, Akre O, Forman D, Madigan MP, Richiardi L & McGlynn KA. (2009) A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer - experiences of the mother. Int J Epidemiol 38, 1532-1542.
16. Cook MB, Akre O, Forman D, Madigan MP, Richiardi L & McGlynn KA. (2010) A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer - experiences of the son. Int J Epidemiol 39, 1605-1618.
17. Czene K, Lichtenstein P & Hemminki K. (2002) Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database. Int J Cancer 99, 260-266.
18. Dallinga JW, Moonen EJ, Dumoulin JC, Evers JL, Geraedts JP & Kleinjans JC. (2002) Decreased human semen quality and organochlorine compounds in blood. Hum Reprod 17, 1973-1979.
19. Damgaard IN, Skakkebaek NE, Toppari J, Virtanen HE, Shen H, Schramm KW, Petersen JH, Jensen TK & Main KM. (2006) Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect 114, 1133-1138.
20. De Jager C, Farias P, Barraza-Villarreal A, Avila MH, Ayotte P, Dewailly E, Dombrowski C, Rousseau F, Sanchez VD & Bailey JL. (2006) Reduced seminal parameters associated with environmental DDT exposure and p, p'-DDE concentrations in men in Chiapas, Mexico: a cross-sectional study. J Androl 27, 16-27.
21. Dhooge W, van LN, Koppen G, Nelen V, Schoeters G, Vlietinck R, Kaufman JM & Comhaire F. (2006) Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population. Environ Health Perspect 114, 1670-1676.
22. Fernandez MF, Olmos B, Granada A, Lopez-Espinosa MJ, Molina-Molina JM, Fernandez JM, Cruz M, Olea-Serrano F & Olea N. (2007) Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study. Environ Health Perspect 115(Suppl. 1), 8-14.
23. Giordano F, Abballe A, De Felip E, di Domenico A, Ferro F, Grammatico P et al. (2010) Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring. Birth Defects Res A Clin Mol Teratol 88, 241-250.
24. Golden R & Kimbrough R. (2009) Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003. Crit Rev Toxicol 39, 299-331.
25. Guo YL, Ryan JJ, Lau BP, Yu ML & Hsu CC. (1997) Blood serum levels of PCBs and PCDFs in Yucheng women 14years after exposure to a toxic rice oil. Arch Environ Contam Toxicol 33, 104-108.
26. Guo YL, Hsu PC, Hsu CC & Lambert GH. (2000) Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 356, 1240-1241.
27. Hardell L, van Bavel B, Lindstrom G, Carlberg M, Dreifaldt AC, Wijkstrom H, Starkhammar H, Eriksson M, Hallquist A & Kolmert T. (2003) Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environ Health Perspect 111, 930-934.
28. Hardell L, Van Bavel B, Lindstrom G, Carlberg M, Eriksson M, Dreifaldt AC, Wijkstrom H, Starkhammar H, Hallquist A & Kolmert T. (2004) Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer. Int J Androl 27, 282-290.
29. Hardell E, Carlberg M, Nordstrom M & van Bavel B. (2010) Time trends of persistent organic pollutants in Sweden during 1993-2007 and relation to age, gender, body mass index, breast-feeding and parity. Sci Total Environ 408, 4412-4419.
30. Hauser R, Chen Z, Pothier L, Ryan L & Altshul L. (2003) The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p, p'-DDE. Environ Health Perspect 111, 1505-1511.
31. Hauser R, Williams P, Altshul L & Calafat AM. (2005) Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility. Environ Health Perspect 113, 425-430.
32. Hopf NB, Ruder AM & Succop P. (2009) Background levels of polychlorinated biphenyls in the US population. Sci Total Environ 407, 6109-6119.
33. Hosie S, Loff S, Witt K, Niessen K & Waag KL. (2000) Is there a correlation between organochlorine compounds and undescended testes? Eur J Pediatr Surg 10, 304-309.
34. Hutson JM, Balic A, Nation T & Southwell B. (2010) Cryptorchidism. Semin Pediatr Surg 19, 215-224.
35. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1987) Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, Volumes 1 to 42, p. 440. International Agency for Research on Cancer, Lyon, France.
36. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1992) Occupational Exposures in Insecticide Application and Some Pesticides: Meeting: Papers. International Agency for Research on Cancer, Lyon, France.
37. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2001) Some Thyrotropic Agents, p. iv, 763 pp. International Agency for Research on Cancer; Distributed by IARC Press and the World Health Organization Distribution and Sales, Lyon, France Geneva.
38. James WH. (2010) Further grounds for abandoning the concept of testicular dysgenesis syndrome: a response to the paper of Akre and Richiardi (2009). Hum Reprod 25, 1084-1086.
39. Jonsson BA, Richthoff J, Rylander L, Giwercman A & Hagmar L. (2005) Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 16, 487-493.
40. Jorgensen N, Rajpert-De Meyts E, Main KM & Skakkebaek NE. (2010) Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl 33, 298-303.
41. Kaushik P & Kaushik G. (2007) An assessment of structure and toxicity correlation in organochlorine pesticides. J Hazard Mater 143, 102-111.
42. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA & Wilson EM. (1995) Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature 375, 581-585.
43. Lerro CC, McGlynn KA & Cook MB. (2010) A systematic review and meta-analysis of the relationship between body size and testicular cancer. Br J Cancer 103, 1467-1474.
44. Longnecker MP, Klebanoff MA, Brock JW, Zhou H, Gray KA, Needham LL & Wilcox AJ. (2002) Maternal serum level of 1, 1-dichloro-2, 2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring. Am J Epidemiol 155, 313-322.
45. Looijenga LH, Hersmus R, de Leeuw BH, Stoop H, Cools M, Oosterhuis JW, Drop SL & Wolffenbuttel KP. (2010) Gonadal tumours and DSD. Best Pract Res Clin Endocrinol Metab 24, 291-310.
46. von der Maase H, Rorth M, Walbom-Jorgensen S, Sorensen BL, Christophersen IS, Hald T, Jacobsen GK, Berthelsen JG & Skakkebaek NE. (1986) Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. Br Med J (Clin Res Ed) 293, 1398-1401.
47. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M & Olafsdottir K. (2005) Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 20, 208-215.
48. McGlynn KA & Cook MB. (2009) The epidemiology of testicular cancer. In: Male Reproductive Cancers: Epidemiology, Pathology and Genetics (eds. KA Cooney & WD Foulkes), pp. 51-83. Springer Publications, New York.
49. McGlynn KA, Devesa SS, Sigurdson AJ, Brown LM, Tsao L & Tarone RE. (2003) Trends in the incidence of testicular germ cell tumors in the United States. Cancer 97, 63-70.
50. McGlynn KA, Quraishi SM, Graubard BI, Weber JP, Rubertone MV & Erickson RL. (2008) Persistent organochlorine pesticides and risk of testicular germ cell tumors. J Natl Cancer Inst 100, 663-671.
51. McGlynn KA, Guo X, Graubard BI, Brock JW, Klebanoff MA & Longnecker MP. (2009a) Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring. Environ Health Perspect 117, 1472-1476.
52. McGlynn KA, Quraishi SM, Graubard BI, Weber J-P, Rubertone MV & Erickson RL. (2009b) Polychlorinated biphenyls and risk of testicular germ cell tumors. Cancer Res 69, 1901-1909.
53. Mocarelli P, Gerthoux PM, Patterson DG Jr, Milani S, Limonta G, Bertona M et al. (2008) Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality. Environ Health Perspect 116, 70-77.
54. Mol NM, Sorensen N, Weihe P, Andersson AM, Jorgensen N, Skakkebaek NE, Keiding N & Grandjean P. (2002) Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls. Eur J Endocrinol 146, 357-363.
55. Moller H. (1989) Decreased testicular cancer risk in men born in wartime. J Natl Cancer Inst 81, 1668-1669.
56. Mostofi FK & Sesterhenn IA. (2004) Tumours of the testis and paratesticular tissue. In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (eds JN Eble, G Sauter, JI Epstein & IA Sesterhenn), pp. 217-278. International Agency for Research on Cancer (IARC) Press, Lyon.
57. Niswander KR & Gordon M. (1972) The Women and Their Pregnancies. WB Saunders Company, Philadelphia.
58. Pant N, Mathur N, Banerjee AK, Srivastava SP & Saxena DK. (2004) Correlation of chlorinated pesticides concentration in semen with seminal vesicle and prostatic markers. Reprod Toxicol 19, 209-214.
59. Pierik FH, Klebanoff MA, Brock JW & Longnecker MP. (2007) Maternal pregnancy serum level of heptachlor epoxide, hexachlorobenzene, and beta-hexachlorocyclohexane and risk of cryptorchidism in offspring. Environ Res 105, 364-369.
60. Purdue MP, Engel LS, Langseth H, Needham LL, Andersen A, Barr DB, Blair A, Rothman N & McGlynn KA. (2009) Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors. Environ Health Perspect 117, 1514-1519.
61. Richthoff J, Rylander L, Jonsson BA, Akesson H, Hagmar L, Nilsson-Ehle P, Stridsberg M & Giwercman A. (2003) Serum levels of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 111, 409-413.
62. Rigét F, Bignert A, Braune B, Stow J & Wilson S. (2010) Temporal trends of legacy POPs in Arctic biota, an update. Sci Total Environ 408, 2874-2884.
63. Rignell-Hydbom A, Rylander L, Giwercman A, Jonsson BA, Nilsson-Ehle P & Hagmar L. (2004) Exposure to CB-153 and p, p'-DDE and male reproductive function. Hum Reprod 19, 2066-2075.
64. Roy JR, Chakraborty S & Chakraborty TR. (2009) Estrogen-like endocrine disrupting chemicals affecting puberty in humans - a review. Med Sci Monit 15, RA137-RA145.
65. Rozati R, Reddy PP, Reddanna P & Mujtaba R. (2002) Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril 78, 1187-1194.
66. Seegal RF, Fitzgerald EF, Hills EA, Wolff MS, Haase RF, Todd AC et al. (2010) Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval. J Expo Sci Environ Epidemiol Mar 10. [Epub ahead of print].
67. Sharpe RM. (2003) The 'oestrogen hypothesis'- where do we stand now? Int J Androl 26, 2-15.
68. Skakkebaek NE, Rajpert-De Meyts E & Main KM. (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16, 972-978.
69. Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L et al. (2009) Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 69, 5241-5250.
70. Swan SH, Elkin EP & Fenster L. (2000) The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 108, 961-966.
71. Toft G, Axmon A, Giwercman A, Thulstrup AM, Rignell-Hydbom A, Pedersen HS et al. (2005) Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study. Environ Health 4, 26.
72. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A, Lindh CH et al. (2006) Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 17, 450-458.
73. Toppari J. (2008) Environmental endocrine disrupters. Sex Dev 2, 260-267.
74. Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr et al. (1996) Male reproductive health and environmental xenoestrogens. Environ Health Perspect 104(Suppl. 4), 741-803.
75. United Nations Environment Programme (UNEP). (1979) DDT and its derivatives, p. 194. World Health Organization, Geneva.
76. United Nations Environment Programme (UNEP). (2001) Stockholm Convention on Persistent Organic Pollutants. Accessed on 10 December 2010, Available at.
77. White R, Jobling S, Hoare SA, Sumpter JP & Parker MG. (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
78. Wohlfahrt-Veje C, Main KM & Skakkebaek NE. (2009) Testicular dysgenesis syndrome; fetal origin of adult reproductive problems. Clin Endocrinol (Oxf) 71, 459-465.
79. Wolff MS & Toniolo PG. (1995) Environmental organochlorine exposure as a potential etiologic factor in breast cancer. Environ Health Perspect 103(Suppl. 7), 141-145.
80. Wolff MS, Fischbein A & Selikoff IJ. (1992) Changes in PCB serum concentrations among capacitor manufacturing workers. Environ Res 59, 202-216.
81. Wolff MS, Camann D, Gammon M & Stellman SD. (1997) Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect 105, 13-14.
82. Wolff MS, Zeleniuch-Jacquotte A, Dubin N & Toniolo P. (2000) Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev 9, 271-277.
83. Zietz BP, Hoopmann M, Funcke M, Huppmann R, Suchenwirth R & Gierden E. (2008) Long-term biomonitoring of polychlorinated biphenyls and organochlorine pesticides in human milk from mothers living in northern Germany. Int J Hyg Environ Health 211, 624-638.