Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway

Reproductive Toxicology

Volumn 32, Issue 3, 2011, Pages 261-267

  Haugen, Trine B ^a,b   Tefre, Toril ^a   Malm, Gunilla ^c   Jönsson, Bo A G ^d   Rylander, Lars ^c,d   Hagmar, Lars ^d   Bjørsvik, Cathrine ^b   Henrichsen, Trine ^b   Sæther, Thomas ^b,e   Figenschau, Yngve ^f   Giwercman, Aleksander ^c  

^a OSLO METROPOLITAN UNIVERSITY   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY OF OSLO   (Norway)

^f UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

CB 153; Geographical difference; Male; Norway; P,p' DDE; POPs; Reproductive hormones; Sperm characteristics

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,2',4,4',5,5' HEXACHLOROBIPHENYL; ESTRADIOL; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ARCTIC; ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FOLLITROPIN BLOOD LEVEL; GEOGRAPHY; HUMAN; MALE; NORWAY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; UROGENITAL SYSTEM PARAMETERS;

ADULT; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; FOLLICLE STIMULATING HORMONE; HUMANS; INHIBINS; LUTEINIZING HORMONE; MALE; NORWAY; POLYCHLORINATED BIPHENYLS; REPRODUCTION; SEX HORMONE-BINDING GLOBULIN; SPERM COUNT; SPERM MOTILITY; TESTOSTERONE; YOUNG ADULT;

EID: 80755139556     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.06.072     Document Type: Article

References (62)

1. Carlsen E., Giwercman A., Keiding N., Skakkebaek N.E. Evidence for decreasing quality of semen during past 50 years. Br Med J 1992, 305:609-613.
2. Auger J., Kunstmann J.M., Czyglik F., Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995, 332:281-285.
3. Swan S.H., Elkin E.P., Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 2000, 108:961-966.
4. Olsen G.W., Bodner K.M., Ramlow J.M., Ross C.E., Lipshultz L.I. Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited. Fertil Steril 1995, 63:887-893.
5. Bujan L., Mansat A., Pontonnier F., Mieusset R. Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992. Br Med J 1996, 312:471-472.
6. Jacobsen R., Moller H., Thoresen S.O., Pukkala E., Kjaer S.K., Johansen C. Trends in testicular cancer incidence in the Nordic countries, focusing on the recent decrease in Denmark. Int J Androl 2006, 29:199-204.
7. Bray F., Richiardi L., Ekbom A., Pukkala E., Cuninkova M., Moller H. Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality. Int J Cancer 2006, 118:3099-3111.
8. Boisen K.A., Kaleva M., Main K.M., Virtanen H.E., Haavisto A.M., Schmidt I.M., et al. Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet 2004, 363:1264-1269.
9. Boisen K.A., Chellakooty M., Schmidt I.M., Kai C.M., Damgaard I.N., Suomi A.M., et al. Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. J Clin Endocrinol Metab 2005, 90:4041-4046.
10. Guven A., Kogan B.A. Undescended testis in older boys: further evidence that ascending testes are common. J Pediatr Surg 2008, 43:1700-1704.
11. Auger J., Jouannet P. Evidence for regional differences of semen quality among fertile French men. Hum Reprod 1997, 12:740-745.
12. Jørgensen N., Andersen A.G., Eustache F., Irvine D.S., Suominen J., Petersen J.H., et al. Regional differences in semen quality in Europe. Hum Reprod 2001, 16:1012-1019.
13. Swan S.H., Brazil C., Drobnis E.Z., Liu F., Kruse R.L., Hatch M., et al. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect 2003, 111:414-420.
14. Paasch U., Salzbrunn A., Glander H.J., Plambeck K., Salzbrunn H., Grunewald S., et al. Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. Int J Androl 2008, 31:93-102.
15. Jacobsen R., Bostofte E., Engholm G., Hansen J., Olsen J.H., Skakkebaek N.E., et al. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. Br Med J 2000, 321:789-792.
16. Jørgensen N., Carlsen E., Nermoen I., Punab M., Suominen J., Andersen A.G., et al. East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 2002, 17:2199-2208.
17. Richthoff J., Rylander L., Hagmar L., Malm J., Giwercman A. Higher sperm counts in Southern Sweden compared with Denmark. Hum Reprod 2002, 17:2468-2473.
18. Sharpe R.M., Skakkebaek N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?. Lancet 1993, 341:1392-1395.
19. Toppari J., Larsen J.C., Christiansen P., Giwercman A., Grandjean P., Guillette L.J., et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 1996, 104(Suppl. 4):741-803.
20. Sharpe R.M. The 'oestrogen hypothesis' - where do we stand now?. Int J Androl 2003, 26:2-15.
21. Guillette L.J. Organochlorine pesticides as endocrine disruptors in wildlife. Cent Eur J Public Health 2000, 8(Suppl.):34-35.
22. Verreault J., Skaare J.U., Jenssen B.M., Gabrielsen G.W. Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus. Environ Health Perspect 2004, 112:532-537.
23. AMAP AMAP assessment 2002: persistent organic pollutants in the Artic Oslo 2004, Artic Monitoring and Assessment Programme (AMAP).
24. Toft G., Rignell-Hydbom A., Tyrkiel E., Shvets M., Giwercman A., Lindh C.H., et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 2006, 17:450-458.
25. Hagmar L., Wallin E., Vessby B., Jönsson B.A., Bergman K., Rylander L. Intra-individual variations and time trends 1991-2001 in human serum levels of PCB, DDE and hexachlorobenzene. Chemosphere 2006, 64:1507-1513.
26. Hagmar L., Bjørk J., Sjødin A., Bergman A., Erfurth E.M. Plasma levels of persistent organohalogens and hormone levels in adult male humans. Arch Environ Health 2001, 56:138-143.
27. Kelce W.R., Gray L.E., Wilson E.M. Antiandrogens as environmental endocrine disruptors. Reprod Fertil Dev 1998, 10:105-111.
28. Bonefeld-Jørgensen E.C., Andersen H.R., Rasmussen T.H., Vinggaard A.M. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology 2001, 158:141-153.
29. Guo Y.L., Hsu P.C., Hsu C.C., Lambert G.H. Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 2000, 356:1240-1241.
30. Hsu P.C., Huang W., Yao W.J., Wu M.H., Guo Y.L., Lambert G.H. Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans. JAMA 2003, 289:2943-2944.
31. Richthoff J., Rylander L., Jønsson B.A., åkesson H., Hagmar L., Nilsson-Ehle P., et al. Serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 2003, 111:409-413.
32. Hauser R., Chen Z., Pothier L., Ryan L., Altshul L. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE. Environ Health Perspect 2003, 111:1505-1511.
33. Hauser R., Williams P., Altshul L., Calafat A.M. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility. Environ Health Perspect 2005, 113:425-430.
34. Toft G., Axmon A., Giwercman A., Thulstrup A.M., Rignell-Hydbom A., Pedersen H.S., et al. Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study. Environ Health 2005, 4:26.
35. Rignell-Hydbom A., Rylander L., Giwercman A., Jönsson B.A., Nilsson-Ehle P., Hagmar L. Exposure to CB-153 and p,p'-DDE and male reproductive function. Hum Reprod 2004, 19:2066-2075.
36. Dalvie M.A., Myers J.E., Thompson M.L., Robins T.G., Dyer S., Riebow J., et al. The long-term effects of DDT exposure on semen, fertility, and sexual function of malaria vector-control workers in Limpopo Province, South Africa. Environ Res 2004, 96:1-8.
37. De Jager C., Farias P., Barraza-Villarreal A., Avila M.H., Ayotte P., Dewailly E., et al. Reduced seminal parameters associated with environmental DDT exposure and p,p'-DDE concentrations in men in Chiapas, Mexico: a cross-sectional study. J Androl 2006, 27:16-27.
38. Aneck-Hahn N.H., Schulenburg G.W., Bornman M.S., Farias P., de Jager C. Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa. J Androl 2007, 28:423-434.
39. Dietz R., Riget F.F., Sonne C., Letcher R., Born E.W., Muir D.C. Seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001. Sci Total Environ 2004, 331:107-124.
40. Evenset A., Christensen G.N., Skotvold T., Fjeld E., Schlabach M., Wartena E., et al. A comparison of organic contaminants in two high Arctic lake ecosystems, Bjørnøya (Bear Island), Norway. Sci Total Environ 2004, 318:125-141.
41. Furberg A.S., Sandanger T., Thune I., Burkow I.C., Lun E. Fish consumption and plasma levels of organochlorines in a female population in Northern Norway. J Environ Monit 2002, 4:175-181.
42. Grimvall E., Rylander L., Nilsson-Ehle P., Nilsson U., Strømberg U., Hagmar L., et al. Monitoring of polychlorinated biphenyls in human blood plasma: methodological developments and influence of age, lactation, and fish consumption. Arch Environ Contam Toxicol 1997, 32:329-336.
43. Glynn A.W., Wolk A., Aune M., Atuma S., Zettermark S., Maehle-Schmid M., et al. Serum concentrations of organochlorines in men: a search for markers of exposure. Sci Total Environ 2000, 263:197-208.
44. Hauser R., Singh N.P., Chen Z., Pothier L., Altshul L. Lack of an association between environmental exposure to polychlorinated biphenyls and p,p'-DDE and DNA damage in human sperm measured using the neutral comet assay. Hum Reprod 2003, 18:2525-2533.
45. Malm G., Haugen T.B., Henrichsen T., Bjørsvik C., Grotmol T., Saether T., et al. Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle. J Clin Endocrinol Metab 2004, 89:4397-4402.
46. Ruhayel Y., Malm G., Haugen T.B., Henrichsen T., Bjorsvik C., Grotmol T., et al. Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study. Clin Endocrinol (Oxf) 2007, 67:85-92.
47. WHO WHO laboratory manual for the examination of semen and sperm-cervical mucus interaction 1999, Cambridge University Press, Cambridge. 4th ed.
48. Kvist U., Bjørndahl L. Manual on basic semen analysis 2002, Oxford University Press, Oxford, United Kingdom.
49. Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
50. Groome N.P., Illingworth P.J., O'Brien M., Pai R., Rodger F.E., Mather J.P., et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996, 81:1401-1405.
51. Petrie A. Lectures notes on medical statistics 1978, Blackwell, London.
52. Pusch K., Schlabach M., Prinzinger R., Wing Gabrielsen G. Gull eggs-food of high organic pollutant content?. J Environ Monit 2005, 7:635-639.
53. Sandanger T.M., Brustad M., Sandau C.D., Lund E. Levels of persistent organic pollutants (POPs) in a coastal northern Norwegian population with high fish-liver intake. J Environ Monit 2006, 8:552-557.
54. Polder A., Thomsen C., Lindstrøm G., Løken K.B., Skaare J.U. Levels and temporal trends of chlorinated pesticides, polychlorinated biphenyls and brominated flame retardants in individual human breast milk samples from Northern and Southern Norway. Chemosphere 2008, 73:14-23.
55. Polder A., Skaare J.U., Skjerve E., Løken K.B., Eggesbø M. Levels of chlorinated pesticides and polychlorinated biphenyls in Norwegian breast milk (2002-2006), and factors that may predict the level of contamination. Sci Total Environ 2009, 407:4584-4590.
56. Jønsson B.A., Rylander L., Lindh C., Rignell-Hydbom A., Giwercman A., Toft G., et al. Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations. Environ Health 2005, 4:27.
57. Svensson B.G., Nilsson A., Jonsson E., Schütz A., åkesson B., Hagmar L. Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen. Scand J Work Environ Health 1995, 21:96-105.
58. Axmon A., Rylander L., Strømberg U., Dyremark E., Hagmar L. Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy. J Toxicol Environ Health 2001, 64:485-498.
59. Bonde J.P., Toft G., Rylander L., Rignell-Hydbom A., Giwercman A., Spano M., et al. Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines. Environ Health Perspect 2008, 116:269-277.
60. Giwercman A., Rylander L., Rignell-Hydbom A., Jonsson B.A., Pedersen H.S., Ludwicki J.K., et al. Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. Pharmacogenet Genomics 2007, 17:391-401.
61. Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 2003, 13:1021-1028.
62. Turyk M.E., Anderson H.A., Freels S., Chatterton R., Needham L.L., Patterson D.G., et al. Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environ Res 2006, 102:299-307.