Host recognition of Clostridium difficile and the innate immune response

Anaerobe

Volumn 30, Issue , 2014, Pages 205-209

  Cowardin, Carrie A ^a   Petri, William A ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Clostridium difficile; Colitis; Inflammation; Innate immune response; Toxins

Indexed keywords

BACTERIAL TOXIN; CYTOKINE; INTERLEUKIN 23; RHO GLUCOSYLATING TOXIN A; RHO GLUCOSYLATING TOXIN B; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL COLONIZATION; BACTERIUM IDENTIFICATION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TOXIN ANALYSIS; CLOSTRIDIUM INFECTION; HUMAN; IMMUNOLOGY; MICROBIOLOGY; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PHYSIOLOGY;

CLOSTRIDIUM DIFFICILE;

BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; SIGNAL TRANSDUCTION;

EID: 84913538845     PISSN: 10759964     EISSN: 10958274     Source Type: Journal    
DOI: 10.1016/j.anaerobe.2014.08.014     Document Type: Article

References (45)

1. Dubberke E.R., Olsen M.A. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis 2012, 55:S88-S92.
2. Bacci S., Mølbak K., Kjeldsen M.K., Olsen K.E.P. Binary toxin and death after Clostridium difficile infection. Emerg Infect Dis 2011, 17:976-982.
3. Bignardi G.E. Risk factors for Clostridium difficile infection. J Hosp Infect 1998, 40:1-15.
4. Poutanen S.M., Simor A.E. Clostridium difficile-associated diarrhea in adults. CMAJ 2004, 171:51-58.
5. Ananthakrishnan A.N. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol 2010, 8:17-26.
6. Loo V.G., Poirier L., Miller M.A., Oughton M., Libman M.D., Michaud S., et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005, 353:2442-2449.
7. Bakken J.S. Fecal bacteriotherapy for recurrent Clostridium difficile infection. Anaerobe 2009, 15:285-289.
8. Jiang Z.-D., DuPont H.L., Garey K., Price M., Graham G., Okhuysen P., et al. A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. Am J Gastroenterol 2006, 101:1112-1116.
9. Feghaly R.E.E., Stauber J.L., Deych E., Gonzalez C., Tarr P.I., Haslam D.B. Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection. Clin Infect Dis 2013, 10.1093/cid/cit147.
10. El Feghaly R.E., Stauber J.L., Tarr P.I., Haslam D.B. Intestinal inflammatory biomarkers and outcome in pediatric Clostridium difficile infections. J Pediatr 2013, 163:1697-1704. e2.
11. Eyre D.W., Cule M.L., Wilson D.J., Griffiths D., Vaughan A., O'Connor L., et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med 2013, 369:1195-1205.
12. Howerton A., Patra M., Abel-Santos E. Fate of ingested Clostridium difficile spores in mice. PLoS ONE 2013, 8:e72620.
13. Schwan C., Stecher B., Tzivelekidis T., van Ham M., Rohde M., Hardt W.-D., et al. Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog 2009, 5:e1000626.
14. Chumbler N.M., Farrow M.A., Lapierre L.A., Franklin J.L., Haslam D., Goldenring J.R., et al. Clostridium difficile toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog 2012, 8:e1003072.
15. Hansen A., Alston L., Tulk S.E., Schenck L.P., Grassie M.E., Alhassan B.F., et al. The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. PLoS ONE 2013, 8:e81491.
16. Sun X., Savidge T., Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins 2010, 2:1848-1880.
17. Flegel W.A., Müller F., Däubener W., Fischer H.G., Hadding U., Northoff H. Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun 1991, 59:3659-3666.
18. Lee J.Y., Kim H., Cha M.Y., Park H.G., Kim Y.-J., Kim I.Y., et al. Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappaB signaling pathway. J Mol Med 2009, 87:169-180.
19. D'Auria K.M., Kolling G.L., Donato G.M., Warren C.A., Gray M.C., Hewlett E.L., et al. In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B. Infect Immun 2013, 10.1128/IAI.00869-13.
20. Jefferson K.K., Smith M.F., Bobak D.A. Roles of intracellular calcium and NF-κB in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 from human monocytes. J Immunol 1999, 163:5183-5191.
21. Bobo L.D., Feghaly R.E.E., Chen Y.-S., Dubberke E.R., Han Z., Baker A.H., et al. MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation. Infect Immun 2013, 81:713-722.
22. Kim H., Rhee S.H., Kokkotou E., Na X., Savidge T., Moyer M.P., et al. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem 2005, 280:21237-21245.
23. Ko S.H., Jeon J.I., Kim H., Kim Y.-J., Youn J., Kim J.M. Mitogen-activated protein kinase/IκB kinase/NF-κB-dependent and AP-1-independent CX3CL1 expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A. J. Mol. Med. 2013, 10.1007/s00109-013-1117-y.
24. Tschopp J., Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?. Nat Rev Immunol 2010, 10:210-215.
25. Ng J., Hirota S.A., Gross O., Li Y., Ulke-Lemee A., Potentier M.S., et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 2010, 139:542-552. 552.e1-3.
26. Strowig T., Henao-Mejia J., Elinav E., Flavell R. Inflammasomes in health and disease. Nature 2012, 481:278-286.
27. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001, 1:135-145.
28. Lawley T.D., Clare S., Walker A.W., Goulding D., Stabler R.A., Croucher N., et al. Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun 2009, 77:3661-3669.
29. Ryan A., Lynch M., Smith S.M., Amu S., Nel H.J., McCoy C.E., et al. A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 2011, 7:e1002076.
30. Jarchum I., Liu M., Shi C., Equinda M., Pamer E.G. Critical role for MyD88-mediated neutrophil recruitment during Clostridium difficile colitis. Infect Immun 2012, 80:2989-2996.
31. Hasegawa M., Yamazaki T., Kamada N., Tawaratsumida K., Kim Y.-G., Núñez G., et al. Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol 2011, 186:4872-4880.
32. Strober W., Murray P.J., Kitani A., Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 2006, 6:9-20.
33. Yoshino Y., Kitazawa T., Ikeda M., Tatsuno K., Yanagimoto S., Okugawa S., et al. Clostridium difficile flagellin stimulates toll-like receptor 5, and toxin B promotes flagellin-induced chemokine production via TLR5. Life Sci 2013, 92:211-217.
34. Jarchum I., Liu M., Lipuma L., Pamer E.G. Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis. Infect Immun 2011, 79:1498-1503.
35. Kelly C.P., Becker S., Linevsky J.K., Joshi M.A., O'Keane J.C., Dickey B.F., et al. Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. J Clin Invest 1994, 93:1257-1265.
36. Ishida Y., Maegawa T., Kondo T., Kimura A., Iwakura Y., Nakamura S., et al. Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis. J Immunol 2004, 172:3018-3025.
37. Wershil B.K., Castagliuolo I., Pothoulakis C. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 1998, 114:956-964.
38. Castagliuolo I., Keates A.C., Wang C.C., Pasha A., Valenick L., Kelly C.P., et al. Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells. J Immunol 1998, 160:6039-6045.
39. Morteau O., Castagliuolo I., Mykoniatis A., Zacks J., Wlk M., Lu B., et al. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology 2002, 122:725-733.
40. Mykoniatis A., Anton P.M., Wlk M., Wang C.C., Ungsunan L., Blüher S., et al. Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 2003, 124:683-691.
41. Hasegawa M., Kamada N., Jiao Y., Liu M.Z., Núñez G., Inohara N. Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J Immunol 2012, 189:3085-3091.
42. Madan R., Guo X., Naylor C., Buonomo E.L., Mackay D., Noor Z., et al. Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infect Immun 2014, 82:341-349.
43. Buonomo E.L., Madan R., Pramoonjago P., Li L., Okusa M.D., Petri W.A. Role of IL-23 signaling in Clostridium difficile Colitis. J Infect Dis 2013, jit277. 10.1093/infdis/jit277.
44. Buffie C.G., Pamer E.G. Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 2013, 13:790-801.
45. Ivanov I.I., Atarashi K., Manel N., Brodie E.L., Shima T., Karaoz U., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.