Alternariol-induced cytotoxicity in Caco-2 cells. Protective effect of the phenolic fraction from virgin olive oil

Toxicon

Volumn 93, Issue , 2015, Pages 103-111

  Chiesi, C ^a   Fernandez Blanco, C ^b   Cossignani, L ^a   Font, G ^b   Ruiz, M J ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Alternariol; Caco 2 cells; Cytotoxic and cytoprotective effect; Extra virgin olive oil; Phenolic compounds; ROS generation

Indexed keywords

ALTERNARIOL; OLEUROPEIN; OLIVE OIL; PHENOL; REACTIVE OXYGEN METABOLITE; TYROSOL; LACTONES; PHENOLS; PLANT EXTRACTS; PLANT OILS; REACTIVE OXYGEN SPECIES; TETRAZOLIUM SALTS; THIAZOLES; THIAZOLYL BLUE;

ANTIOXIDANT ACTIVITY; ARTICLE; CACO 2 CELL LINE; CELL CULTURE; CELL PROLIFERATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; NONHUMAN; OLIVE; OXIDATIVE STRESS; ANALYSIS OF VARIANCE; CACO-2 CELLS; CHEMISTRY; DRUG EFFECTS; HUMANS; METABOLISM;

ANALYSIS OF VARIANCE; CACO-2 CELLS; CELL PROLIFERATION; HUMANS; LACTONES; PHENOLS; PLANT EXTRACTS; PLANT OILS; REACTIVE OXYGEN SPECIES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84912550401     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2014.11.230     Document Type: Article

References (43)

1. P. Artursson, and J. Karlsson Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) 82 4 Caco-2 and emerging alternatives for prediction of intestinal drug transport: a general overview cells Biochem. Biophys. Res. Commun. 175 1991 880 885
2. F. Bensassi, C. Gallerne, and O. Sharaf el Dein Cell death induced by the Alternaria mycotoxin Alternariol Toxicol. Vitro 26 2012 915 923
3. D. Boskou Olive oil composition D. Boskou, Olive Oil Chemistry and Technology 1996 AOCS Press Champaign, Illinois, USA 52 83
4. J. Bouayed, and T. Bohn Exogenous antioxidants - Double-edged swords in cellular redox state. Health beneficial effects at physiologic doses versus deleterious effects at high doses Oxid. Med. Cell. Longev. 3 2010 228 237
5. E.-M. Brugger, J. Wagner, D. Schumacher, K. Koch, J. Podlech, M. Metzler, and L. Lehmann Mutagenicity of the mycotoxin alternariol in cultured mammalian cells Toxicol. Lett. 164 2006 221 230
6. S. Bulotta, R. Corradino, M. Celano, M. D'Agostino, J. Maiuolo, M. Oliverio, A. Procopio, M. Iannone, D. Rotiroti, and D. Russo Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives Food Chem. 127 2011 1609 1614
7. G. Corona, D. Vauzour, A. Amini, and J.P.E. Spencer The impact of gastrointestinal modifications, blood-brain barrier transport, and intracellular metabolism on polyphenol bioavailability: an overview Polyphenols in Human Health and Disease 2014 Elsevier Inc. 591 604
8. M.-I. Covas, M. Fito, O. Khymenets, and R. de la Torre The bioavailability of olive oil phenolic compounds Olives and Olive Oil in Health and Disease Prevention 2010 Elsevier Inc. 699 703
9. C.A. De la Lastra, M.D. Barranco, V. Motilva, and J.M. Herrerías Mediterranean diet and health: biological importance of olive oil Curr. Pharm. Des. 7 2001 933 950
10. R. Di Benedetto, R. Vari, B. Scazzocchio, C. Filesi, C. Santagelo, C. Giovannini, P. Matarrese, M. D'Archivio, and R. Masella Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness Nutr. Metab. Cardiovasc. Dis. 17 2007 535 545
11. F. Driss, and J. El-Benna Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil by scavenging reactive oxygen species produced by human neutrophils Olives and Olive Oil in Health and Disease Prevention 2010 Elsevier Inc. 1289 1294
12. EC (European Communities) Commission regulation (EC) no. 1989/2003 of 6 november 2003 amending regulation (EEC) no 2568/91 on the characteristics of olive oil and olive-pomace oil and on the relevant methods of analysis Off. J. Eur. Union L 295/57 1989 57 77
13. EFSA (European Food Safety Authority) Panel on contaminants in the food Chain. Scientific opinion on the risks for animals and public health related to the presence of Alternaria toxins in feed and food EFSA J. 9 2011 2407
14. FAO (Food and Agriculture Organization of the United Nations) Food Balance Sheet 2009 http://faostat3.fao.org/faostat-gateway/go/to/home/E
15. E. Ferrer, A. Juan-Garcia, G. Font, and M.J. Ruiz Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells Toxicol Vitro 23 2009 1504 1509
16. G. Gioffi, M.S. Pesca, P. De Caprariis, A. Braca, L. Severino, and N. De Tommasi Phenolic compounds in olive oil and olive pomace from Cilento (Campania, Italy) and their antioxidant activity Food Chem. 121 2010 105 111
17. W. Grajek, and A. Olejnik Epithelial cell culture in vitro as a model to study functional properties of food Pol. J. Food Nutr. Sci. 13/54 2004 5 24
18. T. Gutfinger Polyphenols in olive oils JAOCS 1981 966 968
19. S. Isik, A. Karagoz, S. Karaman, and C. Nergiz Proliferative and apoptotic effects of olive extracts on cell lines and healthy human cells Food Chem. 134 2012 29 36
20. G.T. Liu, Y.Z. Qian, P. Zhang, Z.M. Dong, Z.Y. Shi, Y.Z. Zhen, J. Miao, and Y.M. Xu Relationships between Alternaria Alternata and oesophageal Cancer IARC Sci. Publ. 1991 258 262
21. A. Logrieco, A. Bottalico, G. Mulè, A. Moretti, and G. Perrone Epidemiology of toxigenic fungi and their associated mycotoxins for some Mediterranean crops Eur. J. Plant Pathol. 109 2003 645 667
22. G. Lombardi, A. Prosperini, G. Font, and M.J. Ruiz Effect of polyphenols on enniatins-induced cytotoxic effects in mammalian cells Toxicol. Mech. Meth. 22 2012 687 695
23. C. Manna, P. Galletti, V. Cucciolla, O. Moltedo, A. Leone, and V. Zappia The protective effect of the olive oil polyphenol (3,4-Dihydroxyphenyl)ethanol Counteracts reactive oxygen Metabolite-Induced cytotoxicity in Caco-2 cells J. Nutr. 127 1997 286 292
24. C. Manna, P. Galletti, G. Maisto, V. Cucciolla, S. D'Angelo, and V. Zappia Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 Cells FEBS Lett. 470 2000 341 344
25. 2 and its reactive products with isothiocyanates through a simulated gastrointestinal digestion system Food Control 37 2014 326 335
26. G. Meca, J. Mañes, G. Font, and M.J. Ruiz Study of the potential toxicity of enniatins A, A1, B and B1 by evaluation of duodenal and colonic bioavailability applying an in vitro method by Caco-2 cells Toxicon 50 2012 1 11
27. H.K. Obied, P. Karuso, P.D. Prenzler, and K. Robards Novel secoiridoids with antioxidant activity from Australian olive mill waste J. Agric. Food Chem. 55 2007 2848 2853
28. V. Ostry Alternaria mycotoxins: an overview of chemical characterization, producers, toxicity, analysis and occurrence in foodstuffs World Mycotoxins J. 1 2008 175 188
29. E. Perri, A. Raffaelli, and G. Sindona Quantitation of oleuropein in Virgin olive oil by ionspray mass J. Agric. Food Chem. 47 1999 4156 4160
30. A. Prosperini, G. Meca, G. Font, and M.J. Ruiz Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells Food Chem. Toxicol. 50 2012 2356 2361
31. 1 Toxicol. Lett. 222 2013 36 44
32. A. Prosperini, A. Juan-García, G. Font, and M.J. Ruiz Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells Toxicol. Lett. 222 2013 2004 2011
33. M.J. Ruiz, L.E. Festila, and M. Fernandez Comparison of basal cytotoxicity of seven carbamates in CHO-K1 cells Toxicol. Environ. Chem. 88 2006 345 354
34. M.J. Ruiz-Leal, and S.G. George An in vitro procedure for evaluation of early stage oxidative stress in an estabilished fish cell line applied to investigation of PHAH and pesticide toxicity Mar. Environ. Res. 58 2004 631 635
35. Y. Sambruy, S. Ferruzza, G. Ranaldi, and I. De Angelis Intestinal cell culture models Cell. Biol. Toxicol. 17 2001 301 317
36. B. Sarria, R. Mateos, E. Gallardo, S. Ramos, M.A. Martín, L. Bravo, and L. Goya Nitroderivatives of olive oil phenols protect HepG2 cells against oxidative stress Food Chem. Toxicol. 50 2012 3752 3758
37. I. Schreck, U. Deigendesch, B. Burkhardt, D. Marko, and C. Weiss The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor Arch. Toxicol. 86 2012 625 632
38. C. Schwarz, M. Kreutzer, and D. Marko Minor contribution of alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternate infested rice Toxicol. Lett. 214 2012 46 52
39. M. Servili, S. Esposito, R. Fabiani, S. Urbani, A. Taticchi, F. Mariucci, R. Selvaggini, and G.F. Montedoro Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure Inflammopharmacol 17 2009 76 84
40. A. Solhaug, L.L. Vines, L. Ivanova, B. Spilsberg, J.A. Holme, J. Pestka, A. Collins, and G.S. Eriksen Mechanisms involved in alternariol-induced cell cycle arrest Mutat. Res. Fundam. Mol. Mech. Mutagen 738-739 2012 1 11
41. U. Tiemann, W. Tomek, F. Schneider, M. Müller, R. Pöhland, and J. Vanselow The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulose cells in vitro Toxicol. Lett. 186 2009 139 145
42. C. Tiessen, M. Fehr, C. Schawarz, S. Baechler, K. Domnanich, U. Böttler, G. Pahlke, and D. Marko Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether Toxicol. Lett. 216 2013 23 30
43. K. Wollenhaupt, F. Schneider, and U. Tiemann Influence of alternariol (AOH) on regulator proteins of cap-dependent translation in porcine endometrial cells Toxicol. Lett. 182 2008 57 62