Long-term effects of marijuana use on the brain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages 16913-16918

  Filbey, Francesca M ^a   Aslan, Sina ^a,b   Calhoun, Vince D ^c,d   Spence, Jeffrey S ^a   Damaraju, Eswar ^c   Caprihan, Arvind ^c   Segall, Judith ^c  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b Advance MRI LLC   (United States)

^c MIND RESEARCH NETWORK   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Diffusion tensor imaging; Functional connectivity; MRI; Orbitofrontal cortex; Resting state fMRI

Indexed keywords

CANNABIS;

ADULT; ARTICLE; BEHAVIOR CHANGE; BRAIN; BRAIN REGION; BRAIN SIZE; CANNABIS USE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; DIFFUSION TENSOR IMAGING; DOWN REGULATION; DRUG EFFECT; FEMALE; FRACTIONAL ANISOTROPY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAY MATTER; HUMAN; LONG TERM EXPOSURE; MALE; MORPHOMETRICS; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE SCANNER; ONSET AGE; ORBITAL CORTEX; VOXEL BASED MORPHOMETRY; WHITE MATTER; CANNABIS SMOKING; CASE CONTROL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; YOUNG ADULT;

CANNABIS SATIVA;

ADULT; BRAIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MARIJUANA SMOKING; YOUNG ADULT;

EID: 84912544119     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415297111     Document Type: Article

References (55)

1. SAMHSA (2012) Results from the 2011. National Survey on Drug Use and Health: National Findings (Subst Abuse Ment Health Serv Admin, Rockville, MD), NSDUH Series H-30, DHHS Publication No. SMA 06-4194.
2. Lorenzetti V, Lubman DI, Whittle S, Solowij N, Yücel M (2010) Structural MRI findings in long-term cannabis users: What do we know? Subst Use Misuse 45(11):1787-1808.
3. Sneider JT, Gruber SA, Rogowska J, Silveri MM, Yurgelun-Todd DA (2013) A preliminary study of functional brain activation among marijuana users during performance of a virtual water maze task. J Addict 2013:461029.
4. Cousijn J, et al. (2013) Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study. Hum Brain Mapp 35(5):2470-2482.
5. Smith AM, Longo CA, Fried PA, Hogan MJ, Cameron I (2010) Effects of marijuana on visuospatial working memory: An fMRI study in young adults. Psychopharmacology (Berl) 210(3):429-438.
6. van Hell HH, et al. (2010) Chronic effects of cannabis use on the human reward system: An fMRI study. Euro Neuropsychopharmacol 20(3):153-163.
7. Batalla A, et al. (2013) Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users. Addict Biol. 19(4):722-32.
8. Schacht JP, Hutchison KE, Filbey FM (2012) Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology 37(11):2368-2376.
9. Demirakca T, et al. (2011) Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol. Drug Alcohol Depend 114(2-3): 242-245.
10. Ashtari M, et al. (2011) Medial temporal structures and memory functions in adolescents with heavy cannabis use. J Psychiatr Res 45(8):1055-1066.
11. Yücel M, et al. (2008) Regional brain abnormalities associated with long-term heavy cannabis use. Arch Gen Psychiatry 65(6):694-701.
12. Churchwell JC, Lopez-Larson M, Yurgelun-Todd DA (2010) Altered frontal cortical volume and decision making in adolescent cannabis users. Front Psychol 1:225.
13. Cousijn J, et al. (2012) Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls. Neuroimage 59(4): 3845-3851.
14. McQueeny T, et al. (2011) Gender effects on amygdala morphometry in adolescent marijuana users. Behav Brain Res 224(1):128-134.
15. Gilman JM, et al. (2014) Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. J Neurosci 34(16):5529-5538.
16. Block RI, et al. (2000) Effects of frequent marijuana use on brain tissue volume and composition. Neuroreport 11(3):491-496.
17. Tzilos GK, et al. (2005) Lack of hippocampal volume change in long-term heavy cannabis users. Am J Addict 14(1):64-72.
18. Battistella G, et al. (2014) Long-term effects of cannabis on brain structure. Neuropsychopharmacology 39(9):2041-2048.
19. Tsou K, Brown S, Sañudo-Peña MC, Mackie K, Walker JM (1998) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83(2):393-411.
20. van den Heuvel M, Mandl R, Luigjes J, Hulshoff Pol H (2008) Microstructural organization of the cingulum tract and the level of default mode functional connectivity. J Neurosci 28(43):10844-10851.
21. Greicius MD, Supekar K, Menon V, Dougherty RF (2009) Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 19(1):72-78.
22. Segall JM, et al. (2012) Correspondence between structure and function in the human brain at rest. Front Neuroinform 6:10.
23. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE (2009) Marijuana craving in the brain. Proc Natl Acad Sci USA 106(31):13016-13021.
24. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE (2010) Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology 35(4):967-975.
25. Tung KC, et al. (2013) Alterations in resting functional connectivity due to recent motor task. Neuroimage 78:316-324.
26. Wakana S, et al. (2007) Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 36(3):630-644.
27. Stephens RS, Babor TF, Kadden R, Miller M; Marijuana Treatment Project Research Group (2002) The Marijuana Treatment Project: Rationale, design and participant characteristics. Addiction 97(Suppl 1):109-124.
28. Cohen MX, Heller AS, Ranganath C (2005) Functional connectivity with anterior cingulate and orbitofrontal cortices during decision-making. Brain Res Cogn Brain Res 23(1):61-70.
29. Cousijn J, Goudriaan AE, Wiers RW (2011) Reaching out towards cannabis: Approachbias in heavy cannabis users predicts changes in cannabis use. Addiction 106(9): 1667-1674.
30. Cheetham A, et al. (2012) Orbitofrontal volumes in early adolescence predict initiation of cannabis use: A 4-year longitudinal and prospective study. Biol Psychiatry 71(8):684-692.
31. Cousijn J, et al. (2013) Cannabis dependence, cognitive control and attentional bias for cannabis words. Addict Behav 38(12):2825-2832.
32. Cousijn J, et al. (2013) Individual differences in decision making and reward processing predict changes in cannabis use: A prospective functional magnetic resonance imaging study. Addict Biol 18(6):1013-1023.
33. Kringelbach ML, O'Doherty J, Rolls ET, Andrews C (2003) Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness. Cereb Cortex 13(10):1064-1071.
34. Bolla KI, et al. (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19(3):1085-1094.
35. Bechara A, Damasio H, Damasio AR (2000) Emotion, decision making and the orbitofrontal cortex. Cereb Cortex 10(3):295-307.
36. Gremel CM, Luo G, Lovinger D, Costa R (2013) Endocannabinoid signaling in orbitofrontal cortex modulates habit formation. Society for Neuroscience Conference (Society for Neuroscience, San Francisco).
37. Orr C, et al. (2013) Altered resting-state connectivity in adolescent cannabis users. Am J Drug Alcohol Abuse 39(6):372-381.
38. Filbey F, Yezhuvath U (2013) Functional connectivity in inhibitory control networks and severity of cannabis use disorder. Am J Drug Alcohol Abuse 39(6):382-391.
39. Harding IH, et al. (2012) Functional connectivity in brain networks underlying cognitive control in chronic cannabis users. Neuropsychopharmacology 37(8):1923-1933.
40. Zhang D, Raichle ME (2010) Disease and the brain's dark energy. Nat Rev Neurol 6(1): 15-28.
41. Tomasi D, Wang GJ, Volkow ND (2013) Energetic cost of brain functional connectivity. Proc Natl Acad Sci USA 110(33):13642-13647.
42. Song SK, et al. (2002) Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 17(3):1429-1436.
43. Delisi LE, et al. (2006) A preliminary DTI study showing no brain structural change associated with adolescent cannabis use. Harm Reduction Journal, 10.1186/1477- 7517-3-17.
44. Cardenas VA, et al. (2013) Not lesser but Greater fractional anisotropy in adolescents with alcohol use disorders. NeuroImage Clinical 2:804-809.
45. De Bellis MD, et al. (2008) Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clin Exp Res 32(3): 395-404.
46. Bilkei-Gorzo A (2012) The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci 367(1607):3326-3341.
47. Kim HJ, Waataja JJ, Thayer SA (2008) Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture. J Pharmacol Exp Ther 325(3):850-858.
48. Bossong MG, Niesink RJ (2010) Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia. Prog Neurobiol 92(3):370-385.
49. Sim-Selley LJ (2003) Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 15(2):91-119.
50. Burston JJ, Wiley JL, Craig AA, Selley DE, Sim-Selley LJ (2010) Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure. Br J Pharmacol 161(1):103-112.
51. Hirvonen J, et al. (2012) Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry 17(6):642-649.
52. Bosker WM, et al. (2012) Medicinal Δ(9) -tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests. Addiction 107(10):1837-1844.
53. Hanson KL, et al. (2010) Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addict Behav 35(11):970-976.
54. Wechsler D (1999) Manual for the Wechsler Abbreviated Scale of Intelligence (The Psychological Corporation, San Antonio).
55. First MB, Spitzer RL, Gibbon M, Williams JBW (1997) User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) (American Psychiatric Press, Washington, DC).