Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats

Phytomedicine

Volumn 19, Issue 11, 2012, Pages 998-1006

  Xue, Mei ^a,b   Jiang, Zhen Zhou ^a   Wu, Tao ^c   Li, Ji ^a   Zhang, Liang ^d   Zhao, Yan ^b   Li, Xue Jun ^b   Zhang, Lu Yong ^a   Yang, Shu Yu ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^c XINJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Anti inflammatory; Hepatotoxicity; Rheumatoid arthritis (RA); Solid lipid nanoparticles (SLN); Tripterygium wilfordii Hook f. (TWHF)

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; EOSIN; FREUND ADJUVANT; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE PEROXIDASE; HEMATOXYLIN; MALONALDEHYDE; SODIUM CHLORIDE; SOLID LIPID NANOPARTICLE; SUPEROXIDE DISMUTASE; TRIPTERYGIUM WILFORDII EXTRACT; XANTHINE OXIDASE;

ADJUVANT ARTHRITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DOUBLE ANTIBODY SANDWICH ENZYME LINKED IMMUNOSORBENT ASSAY; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRIPTERYGIUM WILFORDII;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG-INDUCED LIVER INJURY; EDEMA; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; NANOPARTICLES; OXIDATIVE STRESS; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRIPTERYGIUM;

RATTUS; TRIPTERYGIUM; TRIPTERYGIUM WILFORDII;

EID: 84865236833     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.06.006     Document Type: Article

References (38)

1. J. Bao, and S.M. Dai A Chinese herb Tripterygium wilfordii Hook F. in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety Rheumatology International 31 2011 1123 1129
2. A.M. Brinker, J. Ma, P.E. Lipsky, and I. Raskin Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) Phytochemistry 68 2007 732 766
3. P.H. Canter, H.S. Lee, and E. Ernst A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritis Phytomedicine 13 2006 371 377
4. M. Chen, Y. Ni, H. Duan, Y. Qiu, C. Guo, Y. Jiao, H. Shi, M. Su, and W. Jia Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook f. Chemical Research in Toxicology 21 2008 288 294
5. N.L. Chillingworth, and L.F. Donaldson Characterisation of a Freund's complete adjuvant-induced model of chronic arthritis in mice Journal of Neuroscience Methods 128 2003 45 52
6. Y. Cirpanli, F. Yerlikaya, K. Ozturk, N. Erdogar, M. Launay, C. Gegu, T. Leturgez, E. Bilensoy, S. Calis, and Y. Capan Comparative evaluation of in vitro parameters of tamoxifen citrate loaded poly (lactide-co-glycolide), poly (ε-caprolactone) and chitosan nanoparticles Pharmazie 65 2010 867 870
7. H. Dan, R.X. Peng, Y. Ao, and Y.H. Liu Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats Journal of Biochemical and Molecular Toxicology 22 2008 422 428
8. U. Dhana Lekshmi, G. Poovi, N. Kishore, and P.N. Reddy In vitro characterization and in vivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles International Journal of Pharmaceutics 396 2010 194 203
9. U. Gaur, S.K. Sahoo, T.K. De, P.C. Ghosh, A. Maitra, and P. Ghosh Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system International Journal of Pharmaceutics 202 2000 1 10
10. M.C. Jin, X.H. Chen, and X.K. OuYang Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry Biomedical Chromatography 23 2009 289 294
11. J. Li, Y. Lu, C. Xiao, C. Lu, X. Niu, X. He, H. Zhao, Y. Tan, and A. Lu Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats Journal of Ethnopharmacology 135 2011 270 277
12. R. Li, A. Peng, C. He, X. Wang, J. Shi, L. Chen, and Y. Wei Analysis of triptophenolide and its related compounds from Tripterygium wilfordii Hook f. by electrospray ionization tandem mass spectrometry International Journal of Mass Spectrometry 278 2008 38 49
13. N. Lin, C. Liu, C. Xiao, H. Jia, K. Imada, H. Wu, and A. Ito Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice Biochemical Pharmacology 73 2007 136 146
14. M. Liu, J. Dong, Y. Yang, X. Yang, and H. Xu Characterization and release of triptolide-loaded poly (d,l-lactic acid) nanoparticles European Polymer Journal 41 2005 375 382
15. M. Liu, J. Dong, Y. Yang, X. Yang, and H. Xu Anti-inflammatory effects of triptolide loaded poly (d,l-lactic acid) nanoparticles on adjuvant-induced arthritis in rats Journal of Ethnopharmacology 97 2005 219 225
16. M. Liu, J. Dong, Y. Yang, X. Yang, and H. Xu Effect of poly (d,l-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis Journal of Nanoscience and Nanotechnology 8 2008 3493 3499
17. Y. Liu, H.L. Chen, and G. Yang Extract of Tripterygium wilfordii Hook F. protect dopaminergic neurons against lipopolysaccharide-induced inflammatory damage American Journal of Chinese Medicine 38 2010 801 814
18. J. Ma, M. Dey, H. Yang, A. Poulev, R. Pouleva, R. Dorn, P.E. Lipsky, E.J. Kennelly, and I. Raskin Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii Phytochemistry 68 2007 1172 1178
19. K. Manjunath, and V. Venkateswarlu Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration Journal of Controlled Release 107 2005 215 228
20. W. Mehnert, and K. M der Solid lipid nanoparticles: production, characterization and applications Advanced Drug Delivery Reviews 47 2001 165 196
21. Z.-Z.J. Mei Xue, T. Wu, M. Yan, J.-P. Liu, X.-M. Mu, Y.-W. Su, and L.-Y. Zhang Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats Arzneimittelforschung 61 2011 1 6
22. Z. Mei, X. Li, Q. Wu, S. Hu, and X. Yang The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle Pharmacological Research 51 2005 345 351
23. X.K. Ouyang, M.Q. Cai, X.H. Chen, and M.C. Jin Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum Journal of Analytical Toxicology 32 2008 737 743
24. D. Paolino, D. Cosco, F. Cilurzo, and M. Fresta Innovative drug delivery systems for the administration of natural compounds Current Bioactive Compounds 3 2007 262 277
25. D. Papakostas, F. Rancan, W. Sterry, U. Blume-Peytavi, and A. Vogt Nanoparticles in dermatology Archives for Dermatological Research 303 8 2011 533 550
26. C. Puglia, F. Bonina, L. Rizza, P. Blasi, A. Schoubben, R. Perrotta, M.S. Tarico, and E. Damiani Lipid nanoparticles as carrier for octyl- methoxycinnamate: in vitro percutaneous absorption and photostability studies Journal of Pharmaceutical Sciences 101 2012 301 311
27. M.K. Rawat, A. Jain, A. Mishra, M.S. Muthu, and S. Singh Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery Therapeutic Delivery 1 2010 63 73
28. F. Shao, G. Wang, H. Xie, X. Zhu, and J.A.J. Sun Pharmacokinetic study of triptolide, a constituent of immunosuppressive Chinese Herb Medicine, in rats Biological & Pharmaceutical Bulletin 30 2007 702 707
29. J. Shen, and C. He Isolation and purification of triptolide from the leaves of Tripterygium wilfordii Hook F. Chinese Journal of Chemical Engineering 18 2010 750 754
30. B. Shu, W. Duan, J. Yao, J. Huang, Z. Jiang, and L. Zhang Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells Toxicology in Vitro 23 2009 598 602
31. Y. Wan, W. Sun, H. Zhang, Q. Yan, P. Chen, C. Dou, H. Yang, and M. Ge Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates prolonged mesangial lesions in experimental progressive glomerulonephritis Nephron. Experimental Nephrology 114 2010 e7 e14
32. S.J. Wang, K. Yao, F.D. Xie, and X.H. Ji Effects of Tripterygium wilfordii saponins and interleukin-10 on dendritic cells from human peripheral blood Acta Pharmacologica Sinica 22 2001 721 724
33. W. Weyenberg, P. Filev, D. Van den Plas, J. Vandervoort, K. De Smet, P. Sollie, and A. Ludwig Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application International Journal of Pharmaceutics 337 2007 291 298
34. K.F. Wong, Y. Yi, and J.M. Luk TW (Tripterygium wilfordii) bioactive compounds as anti-cancer and anti-inflammatory agents Clinical and Experimental Pharmacology and Physiology 39 3 2012 311 320
35. M. Xue, Z.-z. Jiang, J.-p. Liu, L.-Y. Zhang, T. Wang, H. Wang, L. Liu, and Z.-x. Zhou Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A Fitoterapia 81 2010 1109 1112
36. J. Yao, L. Zhang, X. Zhao, L. Hu, and Z. Jiang Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry Biological & Pharmaceutical Bulletin 29 2006 1483 1486
37. L. Yu, M. Ao, J. Wan, and Y. Zhang Anti-inflammatory effects of leaf and twig of Tripterygium wilfordii on paw edema in mice Fitoterapia 79 2008 529 532
38. W. Zhang, J. Liu, S. Li, M. Chen, and H. Liu Preparation and evaluation of stealth Tashinone IIA-loaded solid lipid nanoparticles: influence of Poloxamer 188 coating on phagocytic uptake Journal of Microencapsulation 25 2008 203 209