Comparison of the anti-inflammatory and analgesic effects of Gentiana macrophylla Pall. and Gentiana straminea Maxim.; And identification of their active constituents

Journal of Ethnopharmacology

Volumn 144, Issue 3, 2012, Pages 638-645

  Jia, Na ^a   Li, Yuwen ^a   Wu, Yin ^a   Xi, Miaomiao ^a   Hur, Gangmin ^c   Zhang, Xinxin ^b   Cui, Jia ^a   Sun, Wenji ^b   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NORTHWEST UNIVERSITY   (China)

^c Chungnam National University   (South Korea)

Author keywords

Analgesic; Anti inflammatory; Gentiana straminea Maxim; NF B; Traditional Chinese medicine Gentiana macrophylla Pall

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; BETA ACTIN; FLAVONOID; GENTIANA MACROPHYLLA EXTRACT; GENTIANA STRAMINEA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SECOIRIDOID; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; WATER;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CELL DEATH; CELL FRACTIONATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFECT; EAR EDEMA; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; FEMALE; FLOWER; GENTIAN; GENTIANA MACROPHYLLA; GENTIANA STRAMINEA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IN VITRO STUDY; MOUSE; NONHUMAN; PAIN; PAW EDEMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; TRADITIONAL MEDICINE;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; EDEMA; FEMALE; GENTIANA; HOT TEMPERATURE; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B P50 SUBUNIT; PAIN; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTOR RELA; XYLENES;

GENTIANA MACROPHYLLA; GENTIANA STRAMINEA;

EID: 84870294500     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.10.004     Document Type: Article

References (41)

1. B. Adzu, S. Amos, and S.D. Kapu Anti-inflammatory and anti-nociceptive effects of Sphaeranthussenegalensis Journal of Ethnopharmacology 84 2003 169 173
2. S. Akira, and K. Takeda Toll-like receptor signalling Nature Reviews Immunology 4 2004 499 511
3. O. Arihan, M. Boz, A.B. Iskit, and M. Ilhan Antinociceptive activity of coniine in mice Journal of Ethnopharmacology l125 2009 274 278
4. P.A. Baeuerle, and D. Baltimore NF-κB: ten years after Cell 87 1996 13 20
5. G.A. Bentle, S.H. Newton, and J. Brit Starr Journal of Pharmcology 79 1983 125 134
6. C. Bergeron, A. Marston, R. Gauthier, and K. Hostettmann Iridoids and secoiridoids from Gentiana Linearis Phytochemistry 44 1997 633 637
7. J. Claria Cyclooxygenase-2 biology Current Pharmaceutical Design 9 2003 2177 2190
8. H.O.J. Collier, L.C. Dinneen, C.A. Johnson, and C. Schneider British Journal of Pharmacology 12 1968 295
9. Commission of Chinese Materia Medica MateriaMedica of China vol. 7 2004 Shanghai Scientific and Technical Publishers Shanghai, China pp. 313
10. L.C. Denlinger, P.L. Fisette, K.A. Garis, G. Kwon, A. Vazquez-Torres, A.D. Simon, B. Nguyen, R.A. Proctor, P.J. Bertics, and J.A. Corbett Regulation of inducible nitric oxide synthase expression by macrophages purinoreceptors and calcium Journal of Biological Chemistry 271 1996 337 342
11. R. Deraedt, S.Delevallee. Jouquey, and M. Flahaut European Journal of Pharmacology 61 1980 17
12. C.H. Duan, B.J. Shi, L.H. Wu, G.X. Chou, and Z.T. Wang Chemical constituents of Gentiana waltonii Chinese Journal of Natural Medicines 5 2007 417 420
13. I.D.G. Duarte, M. Nakamura, and S.H. Ferreira Brazilian Journal of Medical and Biological Research 21 1988 341
14. L.S. Guzzo, D.A. Saude-Guimaraes, A.C.A. Silva, J.A. Lombardi, H.N. Guimaraes, and A. Grabe-Guimaraes Journal of Ethnopharmacology 135 2008 116 120
15. M.S. Hayden, and S. Ghosh Shared principles in NF-κB signaling Cell 132 2008 344 362
16. K. Hostettmann, G. Bellmann, R. Tabacchi, and A. Jacot-Guillarmod Contribution to the phytochemistry of the genus Gentiana III Helvetica Chimica Acta 56 1973 3050 3054
17. R. Kakuda, T. Iijima, Y. Yaoita, K. Machida, and M. Kikuchi Secoiridoid glycosides from Gentiana scabra Journal of Natural Products 64 2001 1574 1575
18. M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-[κ]B activity Annual Review of Immunology 18 2000 621 663
19. L.Y. Li, B.Z. Ciren, and D. Zhan Comprehensive utilization and develoment of traditionl Tibetan medicine in China Chinese Journal of Chinese Materia Medica 26 2001 808 810
20. L.Y. Li, D. Zhan, and Y.F. Wei Conservation of endangered species resources of Tibetan medicine in China Chinese Journal of Chinese Materia Medica Dictionary 27 2002 561 564
21. J. Luber-Narod, T. Austin-Ritchie, C. Hollins, M. Menon, R.K. Malhotra, and S. Baker Carraway RE Urological Research 25 1997 395
22. P. Luo, Z.F. Zhang, T. Yi, H. Zhang, X.F. Liu, and Z.J. Mo Anti-inflammatory activity of the extracts and fractions from Erigeron multiradiatus through bioassay-guided procedures Journal of Ethnopharmacology 119 2008 232 237
23. Y.H. Ma Research advances in a Tibetan medicine - Gentiana straminea Journal of Anhui Agricultural 33 2005 1698 1699
24. J.M. Muller, H.W. Ziegler-Heitbrock, and P.A. Baeuerle Nuclear factor κ B, amediator of lipopolysaccharide effects Immunobiology 187 1993 233 256
25. A.A. Olajide, A.S. Olubusayo, and M.J. Modupe Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstoniaboonei stem bark Journal of Ethnopharmacology 71 2000 179 186
26. J.Y. Peng, G.R. Fan, and Z.Y. Hong Preparative separation of isovitexin and isoorientin from PatriniavillosaJuss by high-speed counter-current chromatography Journal of Chromatography A 1074 2005 111 115
27. M.C. Recio, R.M. Giner, and S. Manez Structural considerations on the iridoids as anti - inflammatory agents Planta Medica 3 1994 23 34
28. R.A. Ribeiro, M.L. Vale, S.M. Thomazzi, A.B.P. Paschoalato, S. Poole, S.H. Ferreira, and F.Q. Cunha European Journal of Pharmacology 2000 38 111
29. K.A. Sarosiek, L.E. Cavallin, S. Bhatt, N.L. Toomey, Y. Natkunam, W. Blasini, A.J. Gentles, J.C. Ramos, E.A. Mesri, and I.S. Lossos Efficacy of bortezomibin a direct xenograft model of primary effusion lymphoma Proceedings of National Academy of Sciences of the United States of America 107 2010 13069 13074
30. W.L. Smith, R.M. Garavito, and D.L. Dewitt Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2 Journal of Biological Chemistry 271 1996 33157 33160
31. Y.J. Surh, K.S. Chun, H.H. Cha, S.S. Han, Y.S. Keum, K.K. Park, and S.S. Lee Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κ B activation Mutation Research 480-481 2001 243 268
32. R. Tan, J.L. Wolfender, L. Zhang, W. Ma, N. Fuzzati, A. Marston, and K. Hostettmann Acyl secoiridoids and antifungal constituents from Gentiana macrophylla Phytochemistry 42 1996 1305 1313
33. S. Vallabhapurapu, and M. Karin Regulation and function of NF-κB transcription factors in the immune system Annual Review of Immunology 27 2009 693 733
34. P.G. Winyard, and D.A. Willoughby Inflammation Protocols 2003 Humana Press New Jersey pp. 126-185
35. S. Yang The Divine Farmer's Materia Medica 1998 Blue Poppy Press Boulder. Beijing 341-343
36. Yang Y.C.;1991.Zang Yao Zhi. Qinghai Peoples Press. pp. 9-10.
37. E. Yesilada, E. Kupeli, and D.C. Berberiscrataegina Root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats Journal of Ethnopharmacology 79 2002 237 248
38. M. Yoshizaki, T. Tomimori, and T. Namba Pharmacognostical studies on Gleditsia. Flavonoidal constituents in the leaves of Gleditsia japonica Chemical and Pharmaceutical Bulletin 25 1977 3408
39. Zhang F.; Chen J.; Liu Y.;.Chinese Materia Medica Dictionary. In: Shanghai: Shanghai Peoples Press. pp. 255-256
40. L. Zhou, N. Wang, W.X. Yang, H.S. Zhao, and P. Tian The chemical consitituents of Gentiana apiata N. E. B r Journal of Northwest Sci-Tech University of Agriculture 32 2004 89 92
41. X.F. Zhu, and J.Y. Qu Extraction and isolation of chemical constituents from Tibetan medicine Flosgentianaestramienae Journal of TibSci Technology 174 2007 43 44