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Volumn 9, Issue 4, 2014, Pages 1333-1348

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; FOCAL ADHESION KINASE; P21 ACTIVATED KINASE 1; RAC1 PROTEIN; STAT5 PROTEIN; STEM CELL FACTOR; BENZOTHIAZOLE DERIVATIVE; CARBANILAMIDE DERIVATIVE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MUTANT PROTEIN; P21 ACTIVATED KINASE; PROTEIN KINASE INHIBITOR; QUIZARTINIB; STEM CELL FACTOR RECEPTOR; TIAM1 PROTEIN, MOUSE;

EID: 84912133309     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.10.039     Document Type: Article
Times cited : (56)

References (49)
  • 1
    • 80051473568 scopus 로고    scopus 로고
    • Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    • Aksamitiene E., Achanta S., Kolch W., Kholodenko B.N., Hoek J.B., Kiyatkin A. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell. Signal. 2011, 23:1794-1805.
    • (2011) Cell. Signal. , vol.23 , pp. 1794-1805
    • Aksamitiene, E.1    Achanta, S.2    Kolch, W.3    Kholodenko, B.N.4    Hoek, J.B.5    Kiyatkin, A.6
  • 2
    • 84870572352 scopus 로고    scopus 로고
    • Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters
    • Barros P., Lam E.W., Jordan P., Matos P. Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters. Nucleic Acids Res. 2012, 40:7776-7787.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 7776-7787
    • Barros, P.1    Lam, E.W.2    Jordan, P.3    Matos, P.4
  • 5
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M., Baer M.R., Baumann H., Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003, 101:2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 6
    • 0034695446 scopus 로고    scopus 로고
    • CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    • Bourguignon L.Y., Zhu H., Shao L., Chen Y.W. CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J.Biol. Chem. 2000, 275:1829-1838.
    • (2000) J.Biol. Chem. , vol.275 , pp. 1829-1838
    • Bourguignon, L.Y.1    Zhu, H.2    Shao, L.3    Chen, Y.W.4
  • 7
    • 84866416397 scopus 로고    scopus 로고
    • Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia
    • Brady A., Gibson S., Rybicki L., Hsi E., Saunthararajah Y., Sekeres M.A., Tiu R., Copelan E., Kalaycio M., Sobecks R., et al. Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia. Eur. J. Haematol. 2012, 89:288-293.
    • (2012) Eur. J. Haematol. , vol.89 , pp. 288-293
    • Brady, A.1    Gibson, S.2    Rybicki, L.3    Hsi, E.4    Saunthararajah, Y.5    Sekeres, M.A.6    Tiu, R.7    Copelan, E.8    Kalaycio, M.9    Sobecks, R.10
  • 8
    • 53949096505 scopus 로고    scopus 로고
    • Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells
    • Buongiorno P., Pethe V.V., Charames G.S., Esufali S., Bapat B. Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol. Cancer 2008, 7:73.
    • (2008) Mol. Cancer , vol.7 , pp. 73
    • Buongiorno, P.1    Pethe, V.V.2    Charames, G.S.3    Esufali, S.4    Bapat, B.5
  • 9
    • 0023950976 scopus 로고
    • Establishment of an immature mast cell line from a patient with mast cell leukemia
    • Butterfield J.H., Weiler D., Dewald G., Gleich G.J. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 1988, 12:345-355.
    • (1988) Leuk. Res. , vol.12 , pp. 345-355
    • Butterfield, J.H.1    Weiler, D.2    Dewald, G.3    Gleich, G.J.4
  • 10
    • 33846064194 scopus 로고    scopus 로고
    • FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX
    • Chang F., Lemmon C.A., Park D., Romer L.H. FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol. Biol. Cell 2007, 18:253-264.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 253-264
    • Chang, F.1    Lemmon, C.A.2    Park, D.3    Romer, L.H.4
  • 13
    • 41949100602 scopus 로고    scopus 로고
    • An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    • Deacon S.W., Beeser A., Fukui J.A., Rennefahrt U.E., Myers C., Chernoff J., Peterson J.R. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem. Biol. 2008, 15:322-331.
    • (2008) Chem. Biol. , vol.15 , pp. 322-331
    • Deacon, S.W.1    Beeser, A.2    Fukui, J.A.3    Rennefahrt, U.E.4    Myers, C.5    Chernoff, J.6    Peterson, J.R.7
  • 15
    • 77956460771 scopus 로고    scopus 로고
    • Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation
    • Elias B.C., Bhattacharya S., Ray R.M., Johnson L.R. Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation. Cell Adhes. Migr. 2010, 4:419-430.
    • (2010) Cell Adhes. Migr. , vol.4 , pp. 419-430
    • Elias, B.C.1    Bhattacharya, S.2    Ray, R.M.3    Johnson, L.R.4
  • 16
    • 0038048222 scopus 로고    scopus 로고
    • FAK regulates biological processes important for the pathogenesis of cancer
    • Gabarra-Niecko V., Schaller M.D., Dunty J.M. FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev. 2003, 22:359-374.
    • (2003) Cancer Metastasis Rev. , vol.22 , pp. 359-374
    • Gabarra-Niecko, V.1    Schaller, M.D.2    Dunty, J.M.3
  • 17
    • 57349153946 scopus 로고    scopus 로고
    • A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
    • Golubovskaya V.M., Nyberg C., Zheng M., Kweh F., Magis A., Ostrov D., Cance W.G. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J.Med. Chem. 2008, 51:7405-7416.
    • (2008) J.Med. Chem. , vol.51 , pp. 7405-7416
    • Golubovskaya, V.M.1    Nyberg, C.2    Zheng, M.3    Kweh, F.4    Magis, A.5    Ostrov, D.6    Cance, W.G.7
  • 18
    • 84860478933 scopus 로고    scopus 로고
    • A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth invivo
    • Golubovskaya V.M., Figel S., Ho B.T., Johnson C.P., Yemma M., Huang G., Zheng M., Nyberg C., Magis A., Ostrov D.A., et al. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth invivo. Carcinogenesis 2012, 33:1004-1013.
    • (2012) Carcinogenesis , vol.33 , pp. 1004-1013
    • Golubovskaya, V.M.1    Figel, S.2    Ho, B.T.3    Johnson, C.P.4    Yemma, M.5    Huang, G.6    Zheng, M.7    Nyberg, C.8    Magis, A.9    Ostrov, D.A.10
  • 20
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F., Towatari M., Kiyoi H., Tanimoto M., Kitamura T., Saito H., Naoe T. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000, 19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 21
    • 0037061747 scopus 로고    scopus 로고
    • Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    • Kiyoi H., Ohno R., Ueda R., Saito H., Naoe T. Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene 2002, 21:2555-2563.
    • (2002) Oncogene , vol.21 , pp. 2555-2563
    • Kiyoi, H.1    Ohno, R.2    Ueda, R.3    Saito, H.4    Naoe, T.5
  • 22
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis P.D., Gale R.E., Frew M.E., Harrison G., Langabeer S.E., Belton A.A., Walker H., Wheatley K., Bowen D.T., Burnett A.K., et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001, 98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6    Walker, H.7    Wheatley, K.8    Bowen, D.T.9    Burnett, A.K.10
  • 24
    • 56849115896 scopus 로고    scopus 로고
    • FAK expression regulation and therapeutic potential
    • Li S., Hua Z.C. FAK expression regulation and therapeutic potential. Adv. Cancer Res. 2008, 101:45-61.
    • (2008) Adv. Cancer Res. , vol.101 , pp. 45-61
    • Li, S.1    Hua, Z.C.2
  • 25
    • 33947220301 scopus 로고    scopus 로고
    • FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
    • Li L., Piloto O., Kim K.T., Ye Z., Nguyen H.B., Yu X., Levis M., Cheng L., Small D. FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Br. J. Haematol. 2007, 137:64-75.
    • (2007) Br. J. Haematol. , vol.137 , pp. 64-75
    • Li, L.1    Piloto, O.2    Kim, K.T.3    Ye, Z.4    Nguyen, H.B.5    Yu, X.6    Levis, M.7    Cheng, L.8    Small, D.9
  • 33
    • 0037313015 scopus 로고    scopus 로고
    • Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors
    • Pelletier S., Duhamel F., Coulombe P., Popoff M.R., Meloche S. Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol. Cell. Biol. 2003, 23:1316-1333.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1316-1333
    • Pelletier, S.1    Duhamel, F.2    Coulombe, P.3    Popoff, M.R.4    Meloche, S.5
  • 35
    • 33747189188 scopus 로고    scopus 로고
    • Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
    • Rocnik J.L., Okabe R., Yu J.C., Lee B.H., Giese N., Schenkein D.P., Gilliland D.G. Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood 2006, 108:1339-1345.
    • (2006) Blood , vol.108 , pp. 1339-1345
    • Rocnik, J.L.1    Okabe, R.2    Yu, J.C.3    Lee, B.H.4    Giese, N.5    Schenkein, D.P.6    Gilliland, D.G.7
  • 36
    • 42449145174 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML
    • Sallmyr A., Fan J., Datta K., Kim K.T., Grosu D., Shapiro P., Small D., Rassool F. Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood 2008, 111:3173-3182.
    • (2008) Blood , vol.111 , pp. 3173-3182
    • Sallmyr, A.1    Fan, J.2    Datta, K.3    Kim, K.T.4    Grosu, D.5    Shapiro, P.6    Small, D.7    Rassool, F.8
  • 37
    • 0036644975 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
    • Schmidt A., Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 2002, 16:1587-1609.
    • (2002) Genes Dev. , vol.16 , pp. 1587-1609
    • Schmidt, A.1    Hall, A.2
  • 41
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann K., Bagrintseva K., Schwab R., Schmieja K., Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin. Cancer Res. 2003, 9:2140-2150.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 43
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse K.F., Mukherjee G., Small D. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 2000, 14:1766-1776.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3
  • 44
    • 78549281809 scopus 로고    scopus 로고
    • Essential role for focal adhesion kinase in regulating stress hematopoiesis
    • Vemula S., Ramdas B., Hanneman P., Martin J., Beggs H.E., Kapur R. Essential role for focal adhesion kinase in regulating stress hematopoiesis. Blood 2010, 116:4103-4115.
    • (2010) Blood , vol.116 , pp. 4103-4115
    • Vemula, S.1    Ramdas, B.2    Hanneman, P.3    Martin, J.4    Beggs, H.E.5    Kapur, R.6
  • 45
    • 84876011758 scopus 로고    scopus 로고
    • PAK signaling in cancer
    • Ye D.Z., Field J. PAK signaling in cancer. Cell. Logist. 2012, 2:105-116.
    • (2012) Cell. Logist. , vol.2 , pp. 105-116
    • Ye, D.Z.1    Field, J.2
  • 46
    • 80052088126 scopus 로고    scopus 로고
    • Focal adhesion kinase as a target in the treatment of hematological malignancies
    • Yin B. Focal adhesion kinase as a target in the treatment of hematological malignancies. Leuk. Res. 2011, 35:1416-1418.
    • (2011) Leuk. Res. , vol.35 , pp. 1416-1418
    • Yin, B.1
  • 47
    • 0034605042 scopus 로고    scopus 로고
    • Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
    • Zhang S., Fukuda S., Lee Y., Hangoc G., Cooper S., Spolski R., Leonard W.J., Broxmeyer H.E. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J.Exp. Med. 2000, 192:719-728.
    • (2000) J.Exp. Med. , vol.192 , pp. 719-728
    • Zhang, S.1    Fukuda, S.2    Lee, Y.3    Hangoc, G.4    Cooper, S.5    Spolski, R.6    Leonard, W.J.7    Broxmeyer, H.E.8
  • 48
    • 67651085772 scopus 로고    scopus 로고
    • Signal transduction by focal adhesion kinase in cancer
    • Zhao J., Guan J.L. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 2009, 28:35-49.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 35-49
    • Zhao, J.1    Guan, J.L.2


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