Focal adhesion kinase as a target in the treatment of hematological malignancies

Leukemia Research

Volumn 35, Issue 10, 2011, Pages 1416-1418

  Yin, Bu ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Focal adhesion kinase; Leukemia and lymphoma; RNAi knockdown

Indexed keywords

FOCAL ADHESION KINASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; CANCER CELL; CANCER RESISTANCE; CARCINOGENESIS; CELL SURVIVAL; ENZYME ACTIVITY; FOCAL ADHESION KINASE GENE; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HEMATOLOGIC MALIGNANCY; HUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL ADHESION; CELL DIFFERENTIATION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE SILENCING; HUMANS; INTEGRINS; LEUKEMIA, MYELOID, ACUTE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 80052088126     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.04.017     Document Type: Article

References (20)

1. Ozkal S., Paterson J.C., Tedoldi S., et al. Focal adhesion kinase (FAK) expression in normal and neoplastic lymphoid tissues. Pathol Res Pract 2009, 11:781-788.
2. Golubovskaya V., Cance W. Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci 2010, 15:901-912.
3. Golubovskaya V., Kaur A., Cance W. Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim Biophys Acta 2004, 1678:111-125.
4. Parsons J.T. Focal adhesion kinase: the first ten years. J Cell Sci 2003, 116:1409-1416.
5. Frisch S.M., Vuori K., Ruoslahti E., et al. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996, 134:793-799.
6. Kasahara T., Koguchi E., Funakoshi M., et al. Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxid Redox Signal 2002, 4:491-499.
7. Sonoda Y., Matsumoto Y., Funakoshi M., et al. Anti-apoptotic role of focal adhesion kinase (FAK). J Biol Chem 2000, 275:16309-16315.
8. Kurenova E., Xu L.H., Yang X., et al. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol 2004, 24:4361-4371.
9. Hao H., Naomoto Y., Bao X., et al. Focal adhesion kinase as potential target for cancer therapy. Oncol Rep 2009, 22:973-979.
10. Halder J., Kamat A.A., Landen C.N., et al. Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin Cancer Res 2006, 12:4916-4924.
11. Mitra S.K., Lim S.T., Chi A., et al. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene 2006, 25:5969-5984.
12. Pui C.H., Robinson L.L., Look A.T. Acute lymphoblastic leukemia. Lancet 2008, 371:1030-1043.
13. Pui C.H., Relling M.V., Downing J.R. Mechanisms of disease: acute lymphoblastic leukemia. N Engl J Med 2004, 350:1535-1548.
14. Cobaleda C., Sánchez-García I. B-cell acute lymphoblastic leukaemia: towards understanding its cellular origin. Bioessays 2009, 31:600-609.
15. Recher C., Ysebaert L., Beyne-Rauzy O., et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res 2004, 64:3191-3197.
16. Tyner J.W., Walters D.K., Willis S.G., et al. RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood 2008, 111:2238-2245.
17. Glodek A.M., Le Y., Dykxhoorn D.M., et al. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia 2007, 21:1723-1732.
18. Gotoh A., Miyazawa K., Ohyashiki K., et al. Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. Exp Hematol 1995, 23:1153-1159.
19. Le Y., Xu L., Lu J., et al. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol 2009, 84:273-278.
20. Uphoff C.C., MacLeod R.A.F., Denkmann S.A., et al. Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines. Leukemia 1997, 11:441-447.