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Volumn 10, Issue 11, 2014, Pages

Dysregulated B Cell Expression of RANKL and OPG Correlates with Loss of Bone Mineral Density in HIV Infection

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TNFSF11 PROTEIN, HUMAN;

EID: 84912124551     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004497     Document Type: Article
Times cited : (104)

References (43)
  • 1
    • 84861050536 scopus 로고    scopus 로고
    • Metabolic and cardiovascular complications in HIV-infected patients: new challenges for a new age
    • Gandhi RT, Sax PE, Grinspoon SK, (2012) Metabolic and cardiovascular complications in HIV-infected patients: new challenges for a new age. J Infect Dis 205 Suppl 3S353–354.
    • (2012) J Infect Dis , vol.205 , pp. S353-S354
    • Gandhi, R.T.1    Sax, P.E.2    Grinspoon, S.K.3
  • 2
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, et al. (2011) Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis 53: 1120–1126.
    • (2011) Clin Infect Dis , vol.53 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3    Menozzi, M.4    Carli, F.5
  • 3
    • 0034031191 scopus 로고    scopus 로고
    • Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy
    • Tebas P, Powderly WG, Claxton S, Marin D, Tantisiriwat W, et al. (2000) Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS 14: F63–67.
    • (2000) AIDS , vol.14 , pp. F63-F67
    • Tebas, P.1    Powderly, W.G.2    Claxton, S.3    Marin, D.4    Tantisiriwat, W.5
  • 4
    • 33750591177 scopus 로고    scopus 로고
    • Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review
    • Brown TT, Qaqish RB, (2006) Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review. AIDS 20: 2165–2174.
    • (2006) AIDS , vol.20 , pp. 2165-2174
    • Brown, T.T.1    Qaqish, R.B.2
  • 5
    • 77957855493 scopus 로고    scopus 로고
    • Bone disease in HIV infection: a practical review and recommendations for HIV care providers
    • McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, et al. (2010) Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clinical infectious diseases 51: 937–946.
    • (2010) Clinical infectious diseases , vol.51 , pp. 937-946
    • McComsey, G.A.1    Tebas, P.2    Shane, E.3    Yin, M.T.4    Overton, E.T.5
  • 6
    • 0041828172 scopus 로고    scopus 로고
    • Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy
    • Bruera D, Luna N, David DO, Bergoglio LM, Zamudio J, (2003) Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy. AIDS 17: 1917–1923.
    • (2003) AIDS , vol.17 , pp. 1917-1923
    • Bruera, D.1    Luna, N.2    David, D.O.3    Bergoglio, L.M.4    Zamudio, J.5
  • 7
    • 77956229746 scopus 로고    scopus 로고
    • High prevalence of reduced bone mineral density in primary HIV-1-infected men
    • Grijsen ML, Vrouenraets SM, Steingrover R, Lips P, Reiss P, et al. (2010) High prevalence of reduced bone mineral density in primary HIV-1-infected men. Aids 24: 2233–2238.
    • (2010) Aids , vol.24 , pp. 2233-2238
    • Grijsen, M.L.1    Vrouenraets, S.M.2    Steingrover, R.3    Lips, P.4    Reiss, P.5
  • 8
    • 0037442930 scopus 로고    scopus 로고
    • Longitudinal evolution of bone mineral density and bone markers in human immunodeficiency virus-infected individuals
    • Mondy K, Yarasheski K, Powderly WG, Whyte M, Claxton S, et al. (2003) Longitudinal evolution of bone mineral density and bone markers in human immunodeficiency virus-infected individuals. Clin Infect Dis 36: 482–490.
    • (2003) Clin Infect Dis , vol.36 , pp. 482-490
    • Mondy, K.1    Yarasheski, K.2    Powderly, W.G.3    Whyte, M.4    Claxton, S.5
  • 9
    • 84879596021 scopus 로고    scopus 로고
    • Bone health and human immunodeficiency virus infection
    • Schafer JJ, Manlangit K, Squires KE, (2013) Bone health and human immunodeficiency virus infection. Pharmacotherapy 33: 665–682.
    • (2013) Pharmacotherapy , vol.33 , pp. 665-682
    • Schafer, J.J.1    Manlangit, K.2    Squires, K.E.3
  • 10
    • 84862760690 scopus 로고    scopus 로고
    • HIV and Low Bone Density: Responsible Party, or Guilty by Association?
    • Bolland MJ, Grey A, (2011) HIV and Low Bone Density: Responsible Party, or Guilty by Association? IBMS BoneKEy 8: 7–15.
    • (2011) IBMS BoneKEy , vol.8 , pp. 7-15
    • Bolland, M.J.1    Grey, A.2
  • 11
    • 0035808535 scopus 로고    scopus 로고
    • Pathological fractures in AIDS patients with osteopenia and osteoporosis induced by antiretroviral therapy
    • Guaraldi G, Ventura P, Albuzza M, Orlando G, Bedini A, et al. (2001) Pathological fractures in AIDS patients with osteopenia and osteoporosis induced by antiretroviral therapy. AIDS 15: 137–138.
    • (2001) AIDS , vol.15 , pp. 137-138
    • Guaraldi, G.1    Ventura, P.2    Albuzza, M.3    Orlando, G.4    Bedini, A.5
  • 12
    • 51649122545 scopus 로고    scopus 로고
    • Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system
    • Triant VA, Brown TT, Lee H, Grinspoon SK, (2008) Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system. J Clin Endocrinol Metab 93: 3499–3504.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3499-3504
    • Triant, V.A.1    Brown, T.T.2    Lee, H.3    Grinspoon, S.K.4
  • 13
    • 79953877822 scopus 로고    scopus 로고
    • Young B, Dao CN, Buchacz K, Baker R, Brooks JT (2011) Increased Rates of Bone Fracture among HIV-Infected Persons in the HIV Outpatient Study (HOPS) Compared with the US General Population, 2000–2006. Clin Infect Dis. 2011/03/15 ed.
  • 14
    • 79951930013 scopus 로고    scopus 로고
    • Increased risk of fragility fractures among HIV infected compared to uninfected male veterans
    • Womack JA, Goulet JL, Gibert C, Brandt C, Chang CC, et al. (2011) Increased risk of fragility fractures among HIV infected compared to uninfected male veterans. PLoS One 6: e17217.
    • (2011) PLoS One , vol.6 , pp. e17217
    • Womack, J.A.1    Goulet, J.L.2    Gibert, C.3    Brandt, C.4    Chang, C.C.5
  • 15
    • 34548575884 scopus 로고    scopus 로고
    • Fragility fractures and bone mineral density in HIV positive women: a case-control population-based study
    • Prior J, Burdge D, Maan E, Milner R, Hankins C, et al. (2007) Fragility fractures and bone mineral density in HIV positive women: a case-control population-based study. Osteoporos Int 18: 1345–1353.
    • (2007) Osteoporos Int , vol.18 , pp. 1345-1353
    • Prior, J.1    Burdge, D.2    Maan, E.3    Milner, R.4    Hankins, C.5
  • 16
    • 84878226589 scopus 로고    scopus 로고
    • HIV infection is strongly associated with hip fracture risk, independently of age, gender, and comorbidities: a population-based cohort study
    • Guerri-Fernandez R, Vestergaard P, Carbonell C, Knobel H, Aviles FF, et al. (2013) HIV infection is strongly associated with hip fracture risk, independently of age, gender, and comorbidities: a population-based cohort study. J Bone Miner Res 28: 1259–1263.
    • (2013) J Bone Miner Res , vol.28 , pp. 1259-1263
    • Guerri-Fernandez, R.1    Vestergaard, P.2    Carbonell, C.3    Knobel, H.4    Aviles, F.F.5
  • 17
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum SL, (2000) Bone resorption by osteoclasts. Science 289: 1504–1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 18
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: the OPG/RANKL/RANK system
    • Khosla S, (2001) Minireview: the OPG/RANKL/RANK system. Endocrinology 142: 5050–5055.
    • (2001) Endocrinology , vol.142 , pp. 5050-5055
    • Khosla, S.1
  • 19
    • 0032400933 scopus 로고    scopus 로고
    • OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40
    • Yun TJ, Chaudhary PM, Shu GL, Frazer JK, Ewings MK, et al. (1998) OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol 161: 6113–6121.
    • (1998) J Immunol , vol.161 , pp. 6113-6121
    • Yun, T.J.1    Chaudhary, P.M.2    Shu, G.L.3    Frazer, J.K.4    Ewings, M.K.5
  • 20
    • 0037422560 scopus 로고    scopus 로고
    • IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells
    • Toraldo G, Roggia C, Qian WP, Pacifici R, Weitzmann MN, (2003) IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A 100: 125–130.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 125-130
    • Toraldo, G.1    Roggia, C.2    Qian, W.P.3    Pacifici, R.4    Weitzmann, M.N.5
  • 21
    • 84880139498 scopus 로고    scopus 로고
    • The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
    • Weitzmann MN, (2013) The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica 2013: 1–29.
    • (2013) Scientifica , vol.2013 , pp. 1-29
    • Weitzmann, M.N.1
  • 22
    • 33646396235 scopus 로고    scopus 로고
    • Estrogen deficiency and bone loss: an inflammatory tale
    • Weitzmann MN, Pacifici R, (2006) Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116: 1186–1194.
    • (2006) J Clin Invest , vol.116 , pp. 1186-1194
    • Weitzmann, M.N.1    Pacifici, R.2
  • 23
    • 46049112339 scopus 로고    scopus 로고
    • Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    • Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, et al. (2008) Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med 205: 1797–1805.
    • (2008) J Exp Med , vol.205 , pp. 1797-1805
    • Moir, S.1    Ho, J.2    Malaspina, A.3    Wang, W.4    DiPoto, A.C.5
  • 24
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, et al. (2006) PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443: 350–354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3    Brown, J.A.4    Moodley, E.S.5
  • 25
    • 77956378534 scopus 로고    scopus 로고
    • Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats
    • Vikulina T, Fan X, Yamaguchi M, Roser-Page S, Zayzafoon M, et al. (2010) Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A 107: 13848–13853.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13848-13853
    • Vikulina, T.1    Fan, X.2    Yamaguchi, M.3    Roser-Page, S.4    Zayzafoon, M.5
  • 26
    • 34247323904 scopus 로고    scopus 로고
    • B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo
    • Li Y, Toraldo G, Li A, Yang X, Zhang H, et al. (2007) B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood 109: 3839–3848.
    • (2007) Blood , vol.109 , pp. 3839-3848
    • Li, Y.1    Toraldo, G.2    Li, A.3    Yang, X.4    Zhang, H.5
  • 27
    • 84865446399 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
    • Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, et al. (2012) Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem 287: 29851–29860.
    • (2012) J Biol Chem , vol.287 , pp. 29851-29860
    • Onal, M.1    Xiong, J.2    Chen, X.3    Thostenson, J.D.4    Almeida, M.5
  • 28
    • 33748788554 scopus 로고    scopus 로고
    • B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease
    • Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, et al. (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169: 987–998.
    • (2006) Am J Pathol , vol.169 , pp. 987-998
    • Kawai, T.1    Matsuyama, T.2    Hosokawa, Y.3    Makihira, S.4    Seki, M.5
  • 29
    • 63149142646 scopus 로고    scopus 로고
    • B cells in HIV infection and disease
    • Moir S, Fauci AS, (2009) B cells in HIV infection and disease. Nat Rev Immunol 9: 235–245.
    • (2009) Nat Rev Immunol , vol.9 , pp. 235-245
    • Moir, S.1    Fauci, A.S.2
  • 30
    • 33748176405 scopus 로고    scopus 로고
    • Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
    • Titanji K, De Milito A, Cagigi A, Thorstensson R, Grutzmeier S, et al. (2006) Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood 108: 1580–1587.
    • (2006) Blood , vol.108 , pp. 1580-1587
    • Titanji, K.1    De Milito, A.2    Cagigi, A.3    Thorstensson, R.4    Grutzmeier, S.5
  • 31
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas SC, Jilka RL, (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332: 305–311.
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 32
    • 79954615199 scopus 로고    scopus 로고
    • Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice
    • Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, et al. (2011) Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice. Bone 48: 1075–1086.
    • (2011) Bone , vol.48 , pp. 1075-1086
    • Shimizu, Y.1    Sakai, A.2    Menuki, K.3    Mori, T.4    Isse, T.5
  • 33
    • 67149139614 scopus 로고    scopus 로고
    • Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults
    • Collin F, Duval X, Le Moing V, Piroth L, Al Kaied F, et al. (2009) Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults. AIDS 23: 1021–1024.
    • (2009) AIDS , vol.23 , pp. 1021-1024
    • Collin, F.1    Duval, X.2    Le Moing, V.3    Piroth, L.4    Al Kaied, F.5
  • 34
    • 84906761468 scopus 로고    scopus 로고
    • Relative contribution of HIV infection, demographics and body mass index to bone mineral density
    • Cotter AG, Sabin CA, Simelane S, Macken A, Kavanagh E, et al. (2014) Relative contribution of HIV infection, demographics and body mass index to bone mineral density. AIDS 28: 2051–2060.
    • (2014) AIDS , vol.28 , pp. 2051-2060
    • Cotter, A.G.1    Sabin, C.A.2    Simelane, S.3    Macken, A.4    Kavanagh, E.5
  • 35
    • 0023902418 scopus 로고
    • Age and bone mass as predictors of fracture in a prospective study
    • Hui SL, Slemenda CW, Johnston CC, Jr (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81: 1804–1809.
    • (1988) J Clin Invest , vol.81 , pp. 1804-1809
    • Hui, S.L.1    Slemenda, C.W.2    Johnston, C.C.3
  • 37
    • 34548280376 scopus 로고    scopus 로고
    • RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men
    • Gibellini D, Borderi M, De Crignis E, Cicola R, Vescini F, et al. (2007) RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men. J Med Virol 79: 1446–1454.
    • (2007) J Med Virol , vol.79 , pp. 1446-1454
    • Gibellini, D.1    Borderi, M.2    De Crignis, E.3    Cicola, R.4    Vescini, F.5
  • 39
    • 0035210701 scopus 로고    scopus 로고
    • Increased serum osteoprotegerin in disorders characterized by persistent immune activation or glucocorticoid excess–possible role in bone homeostasis
    • Ueland T, Bollerslev J, Godang K, Muller F, Froland SS, et al. (2001) Increased serum osteoprotegerin in disorders characterized by persistent immune activation or glucocorticoid excess–possible role in bone homeostasis. Eur J Endocrinol 145: 685–690.
    • (2001) Eur J Endocrinol , vol.145 , pp. 685-690
    • Ueland, T.1    Bollerslev, J.2    Godang, K.3    Muller, F.4    Froland, S.S.5
  • 40
    • 84864148444 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand (RANKL) and its relationship to coronary atherosclerosis in HIV patients
    • Hwang JJ, Wei J, Abbara S, Grinspoon SK, Lo J, (2012) Receptor activator of nuclear factor-kappaB ligand (RANKL) and its relationship to coronary atherosclerosis in HIV patients. J Acquir Immune Defic Syndr 61: 359–363.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 359-363
    • Hwang, J.J.1    Wei, J.2    Abbara, S.3    Grinspoon, S.K.4    Lo, J.5
  • 41
    • 84880210641 scopus 로고    scopus 로고
    • Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals
    • Brown TT, Chen Y, Currier JS, Ribaudo HJ, Rothenberg J, et al. (2013) Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 63: 323–330.
    • (2013) J Acquir Immune Defic Syndr , vol.63 , pp. 323-330
    • Brown, T.T.1    Chen, Y.2    Currier, J.S.3    Ribaudo, H.J.4    Rothenberg, J.5
  • 42
    • 0036606093 scopus 로고    scopus 로고
    • Diagnosis of osteoporosis and assessment of fracture risk
    • Kanis JA, (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359: 1929–1936.
    • (2002) Lancet , vol.359 , pp. 1929-1936
    • Kanis, J.A.1
  • 43
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    • Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, et al. (2003) Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 111: 1221–1230.
    • (2003) J Clin Invest , vol.111 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1    Khosla, S.2    Sanyal, A.3    Boyle, W.J.4    Lacey, D.L.5


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