Addition of poly (propylene glycol) to multiblock copolymer to optimize siRNA delivery

Bioengineered

Volumn 5, Issue 1, 2013, Pages 30-37

  Dai, Zhi ^a   Arévalo, Maria T ^a   Li, Junwei ^a   Zeng, Mingtao ^a  

^a Texas Tech University Health Sciences Center El Paso   (United States)

Author keywords

Copolymer; Poly(ethylene glycol); Poly(L lysine); Poly(propylene glycol); RNAi; siRNA delivery

Indexed keywords

COPOLYMER; LIPOSOME; POLYPLEX; PROPYLENE GLYCOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DRUG CARRIER; GREEN FLUORESCENT PROTEIN; MACROGOL DERIVATIVE; MICELLE; POLYLYSINE; POLYMER; POLYPROPYLENE GLYCOL; PROPANEDIOL DERIVATIVE; LIPOFECTAMINE; MACROGOL; POLY (PROPYLENE GLYCOL);

ARTICLE; CELL CULTURE; CELL VIABILITY ASSAY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GEL ELECTROPHORESIS; GENE SILENCING; GENE TRANSLOCATION; GENETIC TRANSFECTION; INTERNALIZATION; NONHUMAN; ZETA POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; CYTOLOGY; GENE EXPRESSION; GENETIC TRANSFORMATION; GENETICS; METABOLISM; MICELLE; MOUSE; NERVE CELL; PARTICLE SIZE; STATIC ELECTRICITY; TUMOR CELL LINE; AGAR GEL ELECTROPHORESIS; ANIMAL CELL; CELL VIABILITY; CONTROLLED STUDY; GENE TRANSFER; MTT ASSAY; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RNA BINDING; SYNTHESIS;

ANIMALS; CELL LINE, TUMOR; DRUG CARRIERS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; MICE; MICELLES; MOLECULAR CONFORMATION; NEURONS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYLYSINE; POLYMERS; PROPYLENE GLYCOLS; RNA, SMALL INTERFERING; STATIC ELECTRICITY; TRANSFORMATION, GENETIC;

EID: 84912076619     PISSN: 19491018     EISSN: 19491026     Source Type: Journal    
DOI: 10.4161/bioe.27339     Document Type: Article

References (30)

1. Kim SS, Garg H, Joshi A, Manjunath N. Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol Med 2009; 15:491-500; PMID:19846342; http://dx.doi.org/10.1016/j.molmed.2009.09.001
2. Singha K, Namgung R, Kim WJ. Polymers in small-interfering RNA delivery. Nucleic Acid Ther 2011; 21:133-47; PMID:21749290; http://dx.doi. org/10.1089/nat.2011.0293
3. Kim SS, Subramanya S, Peer D, Shimaoka M, Shankar P. Antibody-mediated delivery of siRNAs for anti-HIV therapy. Methods Mol Biol 2011; 721:339-53; PMID:21431696; http://dx.doi. org/10.1007/978-1-61779-037-9_21
4. Tompkins SM, Lo CY, Tumpey TM, Epstein SL. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A 2004; 101:8682-6; PMID:15173583; http://dx.doi. org/10.1073/pnas.0402630101
5. Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005; 11:50-5; PMID:15619632; http://dx.doi.org/10.1038/ nm1164
6. Li BJ, Tang Q, Cheng D, Qin C, Xie FY, Wei Q, Xu J, Liu Y, Zheng BJ, Woodle MC, et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med 2005; 11:944-51; PMID:16116432
7. Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res 2004; 32:e149; PMID:15520458; http://dx.doi.org/10.1093/nar/gnh140
8. Winkler J, Martin-Killias P, Plückthun A, Zangemeister-Wittke U. EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol Cancer Ther 2009; 8:2674-83; PMID:19723880; http://dx.doi. org/10.1158/1535-7163.MCT-09-0402
9. Rajandram R, Bennett NC, Wang Z, Perry-Keene J, Vesey DA, Johnson DW, Gobe GC. Patient samples of renal cell carcinoma show reduced expression of TRAF1 compared with normal kidney and functional studies in vitro indicate TRAF1 promotes apoptosis: potential for targeted therapy. Pathology 2012; 44:453-9; PMID:22810054; http://dx.doi. org/10.1097/PAT.0b013e3283557748
10. Dou S, Yao YD, Yang XZ, Sun TM, Mao CQ, Song EW, Wang J. Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy. J Control Release 2012; 161:875-83; PMID:22762887; http://dx.doi.org/10.1016/j. jconrel.2012.05.015
11. Yang Y, Hu Y, Wang Y, Li J, Liu F, Huang L. Nanoparticle Delivery of Pooled siRNA for Effective Treatment of Non-Small Cell Lung Caner. Mol Pharm 2012; (Forthcoming); PMID:22686936; http://dx.doi.org/10.1021/mp300152v
12. Kole R, Krainer AR, Altman S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov 2012; 11:125-40; PMID:22262036
13. Castanotto D, Rossi JJ. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009; 457:426-33; PMID:19158789; http://dx.doi. org/10.1038/nature07758
14. Neu M, Fischer D, Kissel T. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med 2005; 7:992-1009; PMID:15920783; http://dx.doi.org/10.1002/ jgm.773
15. Ahn CH, Chae SY, Bae YH, Kim SW. Synthesis of biodegradable multi-block copolymers of poly(Llysine) and poly(ethylene glycol) as a non-viral gene carrier. J Control Release 2004; 97:567-74; PMID:15212887
16. Salcher EE, Wagner E. Chemically programmed polymers for targeted DNA and siRNA transfection. Top Curr Chem 2010; 296:227-49; PMID:21504104; http://dx.doi.org/10.1007/128_2010_69
17. Fukushima S, Miyata K, Nishiyama N, Kanayama N, Yamasaki Y, Kataoka K. PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J Am Chem Soc 2005; 127:2810-1; PMID:15740090; http://dx.doi. org/10.1021/ja0440506
18. Qi R, Liu S, Chen J, Xiao H, Yan L, Huang Y, Jing X. Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery. J Control Release 2012; 159:251-60; PMID:22285552; http://dx.doi.org/10.1016/j.jconrel.2012.01.015
19. Stanic V, Arntz Y, Richard D, Affolter C, Nguyen I, Crucifix C, Schultz P, Baehr C, Frisch B, Ogier J. Filamentous condensation of DNA induced by pegylated poly-L-lysine and transfection efficiency. Biomacromolecules 2008; 9:2048-55; PMID:18572920; http://dx.doi.org/10.1021/ bm800287z
20. Sato A, Choi SW, Hirai M, Yamayoshi A, Moriyama R, Yamano T, Takagi M, Kano A, Shimamoto A, Maruyama A. Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. J Control Release 2007; 122:209-16; PMID:17583369; http:// dx.doi.org/10.1016/j.jconrel.2007.04.018
21. Mishra S, Webster P, Davis ME. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004; 83:97-111; PMID:15202568; http:// dx.doi.org/10.1078/0171-9335-00363
22. Qiu LY, Bae YH. Self-assembled polyethyleniminegraft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials 2007; 28:4132-42; PMID:17582489; http://dx.doi.org/10.1016/j.biomaterials.2007.05.035
23. Sawant RR, Sriraman SK, Navarro G, Biswas S, Dalvi RA, Torchilin VP. Polyethyleneimine-lipid conjugatebased pH-sensitive micellar carrier for gene delivery. Biomaterials 2012; 33:3942-51; PMID:22365809; http://dx.doi.org/10.1016/j.biomaterials.2011.11.088
24. Tian HY, Deng C, Lin H, Sun J, Deng M, Chen X, Jing X. Biodegradable cationic PEG-PEIPBLG hyperbranched block copolymer: synthesis and micelle characterization. Biomaterials 2005; 26:4209-17; PMID:15683643; http://dx.doi. org/10.1016/j.biomaterials.2004.11.002
25. Mao CQ, Du JZ, Sun TM, Yao YD, Zhang PZ, Song EW, Wang J. A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy. Biomaterials 2011; 32:3124-33; PMID:21277018; http://dx.doi.org/10.1016/j.biomaterials.2011.01.006
26. Sharma R, Lee JS, Bettencourt RC, Xiao C, Konieczny SF, Won YY. Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes. Biomacromolecules 2008; 9:3294-307; PMID:18942877; http://dx.doi. org/10.1021/bm800876v
27. Li Y-Y, Hua S-H, Xiao W. wang H-Y, Luo X-H, Li C, Cheng S-X, Zhang X-Z, Zhuo R-X. Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers. J Mater Chem 2011; 21:3100-6; http:// dx.doi.org/10.1039/c0jm03385e
28. Allen MH, Green MD, Getaneh HK, Miller KM, Long TE. Tailoring charge density and hydrogen bonding of imidazolium copolymers for efficient gene delivery. Biomacromolecules 2011; 12:2243-50; PMID:21557603; http://dx.doi.org/10.1021/ bm2003303
29. Vader P, van der Aa LJ, Engbersen JF, Storm G, Schiffelers RM. Disulfide-based poly(amido amine) s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity. Pharm Res 2011; 28:1013-22; PMID:21181546; http://dx.doi.org/10.1007/s11095-010-0344-y
30. Zhou C, Qi X, Li P, Chen WN, Mouad L, Chang MW, Leong SS, Chan-Park MB. High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides. Biomacromolecules 2010; 11:60-7; PMID:19957992; http://dx.doi. org/10.1021/bm900896h