Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints

Environmental and Molecular Mutagenesis

Volumn 55, Issue 9, 2014, Pages 735-740

  Zhou, Changhui ^a   Zhang, Min ^a   Huang, Pengcheng ^a   Tu, Honggang ^a   Wang, Zheng ^a   Dertinger, Stephen D ^b   Torous, Dorothea K ^b   Chang, Yan ^a  

^a National Shanghai Center for New Drug Safety Evaluation and Research   (China)

^b LITRON LABORATORIES   (United States)

Author keywords

4 nitroquinoline 1 oxide; 5 fluorouracil; Flow cytometry; Genotoxicity; Mutation; Pig a

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; FLUOROURACIL; CD59 ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ERYTHROCYTE; GENE; GENE MUTATION; GENOTOXICITY; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN; PHENOTYPE; PHOSPHATIDYLINOSITOL GLYCAN CLASS A GENE; RAT; RETICULOCYTE; WEIGHT GAIN; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; MUTATION; PROCEDURES; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

SUIDAE;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; ANTIGENS, CD59; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FLUOROURACIL; MALE; MICRONUCLEUS TESTS; MUTATION; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; TOXICITY TESTS, ACUTE;

EID: 84912071006     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21893     Document Type: Article

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