Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII-dependent uncoupling of eNOS

FASEB Journal

Volumn 28, Issue 11, 2014, Pages 4719-4728

  Saura, Marta ^a,b   Marquez, Susana ^a,b   Reventun, Paula ^a,b   Olea Herrero, Nuria ^b,c   Arenas, María Isabel ^c,d   Moreno Gómez Toledano, Rafael ^b,c   Gómez Parrizas, Mónica ^e   Muñóz Moreno, Carmen ^b,c   González Santander, Marta ^c,d   Zaragoza, Carlos ^e,f   Bosch, Ricardo J ^b,c  

^a Alcalá de Henares   (Spain)

^b Physiology Unit Department of Systems Biology Alcalá de Henares ^*  (Spain)

^c Physiology Unit   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^f HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

AngII; BPA; Endothelial dysfunction; Hypertension; Superoxide

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ACETYLCHOLINE; ANGIOTENSIN II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOSARTAN; MESSENGER RNA; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG; BENZHYDRYL DERIVATIVE; NOS3 PROTEIN, MOUSE; PHENOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CAROTID ARTERY LIGATION; CELL CULTURE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOPPLER FLOWMETRY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LEISURE; MICROARRAY ANALYSIS; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME ECHOGRAPHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE RELAXATION; SYSTOLIC BLOOD PRESSURE; TIME; ULTRASOUND; VASCULAR ENDOTHELIUM; VASOMOTOR REFLEX; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; ORAL DRUG ADMINISTRATION; PHOSPHORYLATION; PHYSIOLOGY;

ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; BENZHYDRYL COMPOUNDS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; ENDOTHELIUM, VASCULAR; HYPERTENSION; MICE; NITRIC OXIDE SYNTHASE TYPE III; PHENOLS; PHOSPHORYLATION;

EID: 84912059043     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-252460     Document Type: Article

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