A combined therapeutic regimen of buspirone and environmental enrichment is more efficacious than either alone in enhancing spatial learning in brain-injured pediatric rats

Journal of Neurotrauma

Volumn 31, Issue 23, 2014, Pages 1934-1941

  Monaco, Christina M ^a,b,e   Gebhardt, Kory M ^a,b,f   Chlebowski, Sarah M ^a,b,g   Shaw, Kaitlyn E ^a,b   Cheng, Jeffrey P ^a,b   Henchir, Jeremy J ^b   Zupa, Margaret F ^d   Kline, Anthony E ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

^e PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^f NORTHWESTERN MEMORIAL HOSPITAL   (United States)

^g SALUS UNIVERSITY   (United States)

Author keywords

5 ht1a receptor agonist; Beam walking; Behavior; Controlled cortical impact (CCI); Functional recovery; Hippocampus; Learning and memory; Morris water maze; Traumatic brain injury

Indexed keywords

BUSPIRONE; SODIUM CHLORIDE; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX LESION; BRAIN SIZE; CONTROLLED STUDY; DRUG EFFICACY; ENVIRONMENTAL ENRICHMENT; HISTOPATHOLOGY; MALE; MORRIS WATER MAZE TEST; NONHUMAN; OPTIMAL DRUG DOSE; PERINATAL PERIOD; POSTOPERATIVE PERIOD; RAT; SPATIAL LEARNING; SPATIAL MEMORY; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURIES; CONVALESCENCE; DRUG EFFECTS; ENVIRONMENT; MAZE TEST; PHYSIOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN INJURIES; BUSPIRONE; ENVIRONMENT; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SEROTONIN RECEPTOR AGONISTS;

EID: 84912056990     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2014.3541     Document Type: Article

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