Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

Molecular Immunology

Volumn 63, Issue 2, 2015, Pages 337-342

  Wu, Chun Li ^a   Wu, Qiu Yue ^a   Du, Jing Jing ^a   Zeng, Jing Ya ^a   Li, Ting Ting ^b   Xu, Chang Qing ^b   Sun, Yi Hua ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Calcium sensing receptor; Cytokine; Lymphocyte; Sepsis; Signaling transduction pathway

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM SENSING RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; TECALCET; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CECAL LIGATION AND PUNCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; LIGATION; MOLECULAR WEIGHT; NONHUMAN; PROTEIN EXPRESSION; PUNCTURE; RAT; SEPSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WESTERN BLOTTING; ANIMAL; CECUM; DRUG EFFECTS; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; APOPTOSIS; CECUM; FLOW CYTOMETRY; INTERLEUKIN-4; LIGATION; MICE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PUNCTURES; RATS, WISTAR; RECEPTORS, CALCIUM-SENSING; SEPSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84912003261     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.08.007     Document Type: Article

References (25)

1. Atmatzidis S., Koutelidakis I.M., Chatzimavroudis G., Kotsaki A., Louis K., Pistiki A., Savva A., Antonopoulou A., Atmatzidis K., Giamarellos-Bourboulis E.J. Detrimental effect of apoptosis of lymphocytes at an early time point of experimental abdominal sepsis. BMC Infect. Dis. 2011, 11:321-340.
2. Boomer J.S., Green J.M., Hotchkiss R.S. The changing immune system in sepsis is individualized immuno-modulatory therapy the answer?. Virulence 2014, 5:45-56.
3. Canaff L., Hendy G.N. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB Pathway and kappaB elements. J. Biol. Chem. 2005, 280(April (14)):14177-14188.
4. Chan A.S., Yip E.C., Yung L.Y., Pang H., Luk S.C., Pang S.F., Wong Y.H. Immuno-regulatory effects of CKBM on the activities of Mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells. Biol. Pharm. Bull. 2005, 28:1645-1650.
5. Chang K.C., Unsinger J., Davis C.G., Schwulst S.J., Muenzer J.T., Strasser A., Hotchkiss R.S. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J. 2007, 21:708-719.
6. Chaudhry H., Zhou J., Zhong Y., Ali M.M., McGuire F., Nagarkatti P.S., Nagarkatti M. Role of cytokines as a double-edged sword in sepsis. In Vivo 2013, 27:669-684.
7. Feng S.L., Sun M.R., Li T.T., Yin X., Xu C.Q., Sun Y.H. Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes. Biochem. Biophys. Res. Commmun. 2011, 406:278-284.
8. Hammond C.M., White D., Tomic J., Shi Y., Spaner D.E. Exreacellular calcium sensing promotes human B-cell activation and function. Blood 2007, 110:3985-3995.
9. Hasan Z., Palani K., Zhang S., Lepsenyi M., Hwaiz R., Rahman M., Syk I., Jeppsson B., Thorlacius H. Rho kinase regulates induction of T-cell immune dysfunction in abdominal sepsis. Infect. Immun. 2013, 81:2499-2506.
10. Hotchkiss R.S., Nicholson D.W. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 2006, 6:813-822.
11. Hotchkiss R.S., Osmon S.B., Chang K.C., Wagner T.H., Coopersmith C.M., Karl I.E.J. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J. Immunol. 2005, 174:5110-5118.
12. Kantham L., Quinn S.J., Egbuna O.I., Baxi K., Butters R., Pang J.L., Pollak M.R., Goltzman D., Brown E.M. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E915-E923.
13. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 2001, 81:807-869.
14. Lang J.D., Matute-Bello G. Lymphocytes, apoptosis and sepsis: making the jump from mice to humans. Crit. Care 2009, 13:109-115.
15. Liu Z.G., Ni S.Y., Chen G.M., Cai J., Guo Z.H., Chang P., Li Y.S. Histones-mediated lymphocyte apoptosis during sepsis is dependent on p38 phosphorylation and mitochondrial permeability transition. PLOS ONE 2013, 8:e77131.
16. Luan Y.Y., Dong N., Xie M., Xiao X.Z., Yao Y.M. The significance and regulatory mechanisms of innate immune cells in the development of sepsis. J. Interferon. Cytokine Res. 2014, 34:2-15.
17. Molostvov G., Fletcher S., Bland R., Zehnder D. Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis. Cell. Physiol. Biochem. 2008, 22:413-422.
18. O'Sullivan A.W., Wang J.H., Redmond H.P. NF-kappaB and p38 MAPK inhibition improve survival in endotoxin shock and in a cecal ligation and puncture model of sepsis in combination with antibiotic therapy. J. Surg. Res. 2009, 152:46-53.
19. Rittirsch D., Huber-Lang M.S., Flierl M.A., Ward P.A. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 2009, 4:31-36.
20. Sun Y.H., Liu M.N., Li H., Shi S., Zhao Y.J., Wang R., Xu C.Q. Calcium-sensing receptor induces rat neonatal ventricular cardiomyocytes apoptosis. Biochem. Biophys. Res. Commmun. 2006, 350:942-948.
21. Sun Y.H., Li Y.Q., Feng S.L., Li B.X, Pan Z.W., Xu C.Q., Yang B.F. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes. Biochem. Biophys. Res. Commun. 2010, 394:955-961.
22. Tu C.L., Chang W., Xie Z., Bikle D.D. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J. Biol. Chem. 2008, 283:3519-3528.
23. Wagner K., Schmidt J.W. The two faces of Janus kinases and their respective STATs in mammary gland development and cancer. J. Carcinog. 2011, 10:32-60.
24. Wu H.P., Chung K., Lin C.Y., Jiang B.Y., Chuang D.Y., Liu Y.C. Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis. Inflamm. Res. 2013, 62:751-763.
25. Zhu W., Bao R., Fan X., Tao T., Zhu J., Wang J., Li J., Bo L., Deng X. PD-L1 blockade attenuated sepsis-induced liver injury in mouse cecal ligation and puncture model. Mediators Inflamm. 2013, 2013:361501.