Emergent properties of microglia

Brain Pathology

Volumn 24, Issue 6, 2014, Pages 665-670

  Svahn, Adam J ^a   Becker, Thomas S ^a   Graeber, Manuel B ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Alzheimer's disease; emergence; inflammation; interactome; microglial activation; neurotoxicity; proteome; systems biology; transcriptome

Indexed keywords

PROTEOME; TRANSCRIPTOME;

ALZHEIMER DISEASE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; GLIOSIS; HUMAN; INFLAMMATION; MACROPHAGE; MICROGLIA; MONOCYTE; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; RETICULOENDOTHELIAL SYSTEM; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; IMMUNOMODULATION; PHYSIOLOGY;

ANIMALS; COMPUTER SIMULATION; MICROGLIA; MODELS, IMMUNOLOGICAL; NEUROIMMUNOMODULATION;

EID: 84912001146     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12195     Document Type: Article

References (57)

1. Aisen PS, (2002) The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol 1: 279-284.
2. Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, et al (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 289: 2819-2826.
3. Balch WE, Roth DM, Hutt DM, (2011) Emergent properties of proteostasis in managing cystic fibrosis. Cold Spring Harb Perspect Biol 3: 1-16.
4. Bar Yam Y, (2004) A mathematical theory of strong emergence using multiscale variety. Complexity 9: 15-24.
5. Bedau MA, (1997) Weak emergence. Noûs 31: 375-399.
6. Bedau MA, Humphreys PE, (2008) Emergence: Contemporary Readings in Philosophy and Science. The MIT Press: Cambridge, MA. ISBN 9780262524759.
7. Beutner C, Linnartz-Gerlach B, Schmidt SV, Beyer M, Mallmann MR, Staratschek-Jox A, et al (2013) Unique transcriptome signature of mouse microglia. Glia 61: 1429-1442.
8. Bhalla US, Iyengar R, (1999) Emergent properties of networks of biological signaling pathways. Science 283: 381-387.
9. Bialas AR, Stevens B, (2013) TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci 16: 1773-1782.
10. Bilbo SD, Schwarz JM, (2012) The immune system and developmental programming of brain and behavior. Front Neuroendocrinol 33: 267-286.
11. Boulanger LM, (2009) Immune proteins in brain development and synaptic plasticity. Neuron 64: 93-109.
12. Calsavara AC, Rodrigues DH, Miranda AS, Costa PA, Lima CX, Vilela MC, et al (2013) Late anxiety-like behavior and neuroinflammation in mice subjected to sublethal polymicrobial sepsis. Neurotox Res 24: 103-108.
13. Cartwright J, (2013) Physicists discover a whopping 13 new solutions to three-body problem. Available at: http://news.sciencemag.org/physics/2013/03/physicists-discover-whopping-13-new-solutions-three-body-problem (accessed August 6, 2014).
14. Cerejeira J, Firmino H, Vaz-Serra A, Mukaetova-Ladinska EB, (2010) The neuroinflammatory hypothesis of delirium. Acta Neuropathol 119: 737-754.
15. Del Rio-Hortega P, (1932) Cytology and Cellular Pathology of the Nervous System. Paul B Hoeber: New York, pp. 481-534.
16. Del Negro CA, Morgado-Valle C, Feldman JL, (2002) Respiratory rhythm: an emergent network property? Neuron 34: 821-830.
17. Efroni S, Harel D, Cohen IR, (2007) Emergent dynamics of thymocyte development and lineage determination. PLoS Comput Biol 3: e13.
18. El-Hani CN, Emmeche C, (2000) On some theoretical grounds for an organism-centered biology: property emergence, supervenience, and downward causation. Theory Biosci 119: 234-275.
19. Filiou MD, Arefin AS, Moscato P, Graeber MB, (2014) "Neuroinflammation" differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared. Neurogenetics 15: 201-212.
20. Graeber MB, Streit WJ, Kreutzberg GW, (1988) Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J Neurosci Res 21: 18-24.
21. Gyoneva S, Davalos D, Biswas D, Swanger SA, Garnier-Amblard E, Loth F, et al (2014) Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia 62: 1345-1360.
22. Hall AA, Herrera Y, Ajmo CT, Cuevas J, Pennypacker KR, (2009) Sigma receptors suppress multiple aspects of microglial activation. Glia 57: 744-754.
23. (2+) signaling and cell survival. Cell 131: 596-610.
24. Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang L, Means TK, El Khoury J, (2013) The microglial sensome revealed by direct RNA sequencing. Nat Neurosci 16: 1896-1905.
25. Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ, (2000) Functional requirement for class I MHC in CNS development and plasticity. Science 290: 2155-2159.
26. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A, (2011) Physiology of microglia. Physiol Rev 91: 461-553.
27. Kim J, (2006) Emergence: core ideas and issues. Synthese 151: 547-559.
28. Krueger JM, Rector DM, Roy S, Van Dongen HPA, Belenky G, Panksepp J, (2008) Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci 9: 910-919.
29. Lee H, Brott BK, Kirkby LA, Adelson JD, Cheng S, Feller MB, et al (2014) Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature 509: 195-200.
30. Lenz KM, McCarthy MM, (2014) A starring role for microglia in brain sex differences. Neuroscientist. 2014 May 28. pii: 1073858414536468.
31. Linnartz B, Kopatz J, Tenner AJ, Neumann H, (2012) Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia. J Neurosci 32: 946-952.
32. Loo D, (2011) In situ detection of apoptosis by the TUNEL assay: an overview of techniques. Chapter 1. In: DNA Damage Detection In Situ, Ex Vivo, and In Vivo., VV Didenko, (ed.), pp. 3-13. Humana Press: Totowa, NJ.
33. Maurice T, Su T-P, (2009) The pharmacology of sigma-1 receptors. Pharmacol Ther 124: 195-206.
34. McLaughlin P, Zhou Y, Ma T, Liu J, Zhang W, Hong J-S, et al (2006) Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. Glia 53: 567-582.
35. Monji A, (2012) [The neuroinflammation hypothesis of psychiatric disorders]. Seishin Shinkeigaku Zasshi 114: 124-133.
36. Moran LB, Duke DC, Turkheimer FE, Banati RB, Graeber MB, (2004) Towards a transcriptome definition of microglial cells. Neurogenetics 5: 95-108.
37. Neher JJ, Neniskyte U, Brown GC, (2012) Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration. Front Pharmacol 3: 27.
38. Orre M, Kamphuis W, Osborn LM, Melief J, Kooijman L, Huitinga I, et al (2014) Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiol Aging 35: 1-14.
39. Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, et al (2011) Synaptic pruning by microglia is necessary for normal brain development. Science 333: 1456-1458.
40. Parakalan R, Jiang B, Nimmi B, Janani M, Jayapal M, Lu J, et al (2012) Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain. BMC Neurosci 13: 64.
41. Parkhurst CN, Yang G, Ninan I, Savas JN, Yates I, John R, et al (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155: 1596-1609.
42. Reines SA, Block GA, Morris JC, Liu G, Nessly ML, Lines CR, et al (2004) Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology 62: 66-71.
43. Schadt EE, (2009) Molecular networks as sensors and drivers of common human diseases. Nature 461: 218-223.
44. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, et al (2012) Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74: 691-705.
45. Schwarz JM, Sholar PW, Bilbo SD, (2012) Sex differences in microglial colonization of the developing rat brain. J Neurochem 120: 948-963.
46. Searle JR, (1992) The Rediscovery of the Mind. MIT Press: Cambridge, MA, p. 126. ISBN 9780262691543.
47. Searle JR, (1995) Consciousness, the brain and the connection principle: a reply. Philos Phenomenol Res 55: 217-232.
48. Searle JR, (2008) Reductionism and the irreducibility of consciousness. Chapter 3. In: Emergence., MA Bedau, P Humphreys, (eds), pp. 69-80. The MIT Press: Cambridge, MA. ISBN 9780262524759.
49. Stanford encyclopedia of philosophy. Available at: http://plato.stanford.edu/entries/properties-emergent/ (accessed August 6, 2014).
50. Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, et al (2007) The classical complement cascade mediates CNS synapse elimination. Cell 131: 1164-1178.
51. Surprenant A, North RA, (2009) Signaling at purinergic P2X receptors. Annu Rev Physiol 71: 333-359.
52. Svahn AJ, Graeber MB, Ellett F, Lieschke GJ, Rinkwitz S, Bennett MR, Becker TS, (2012) Development of ramified microglia from early macrophages in the zebrafish optic tectum. Dev Neurobiol 73: 60-71.
53. Turing AM, (1953) The chemical basis of morphogenesis. Bull Math Biol 52: 153-197, discussion 19-52.
54. Varela FJ, Coutinho A, (1991) Second generation immune networks. Immunol Today 12: 159-166.
55. Witherington DC, (2011) Taking emergence seriously: the centrality of circular causality for dynamic systems approaches to development. Hum Dev 54: 66-92.
56. Wolfram S, (1985) Undecidability and intractability in theoretical physics. Phys Rev Lett 54: 735-738.
57. Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F, et al (2014) Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci 17: 400-406.