Saliva testosterone and cortisol in male depressive syndrome, a community study. The Sudurnesjamenn Study

Nordic Journal of Psychiatry

Volumn 68, Issue 8, 2014, Pages 579-587

  Sigurdsson, Bjarni ^a   Palsson, Sigurdur Pall ^b   Aevarsson, Olafur ^a   Olafsdottir, Maria ^c   Johannsson, Magnus ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c Arbaer Health Clinic Primary Health Care of the Capital Area   (Iceland)

Author keywords

Community; Cortisol; Depression; Males; Testosterone

Indexed keywords

HYDROCORTISONE; PSYCHOTROPIC AGENT; TESTOSTERONE;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; COMMUNITY ASSESSMENT; COMMUNITY SAMPLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DRUG SCREENING; HUMAN; MAJOR CLINICAL STUDY; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; SALIVA LEVEL; CHEMISTRY; DEPRESSIVE DISORDER; METABOLISM; MIDDLE AGED; PSYCHOLOGICAL RATING SCALE; SALIVA; SECRETION (PROCESS);

DEPRESSIVE DISORDER; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; SALIVA; TESTOSTERONE;

EID: 84911998680     PISSN: 08039488     EISSN: 15024725     Source Type: Journal    
DOI: 10.3109/08039488.2014.898791     Document Type: Article

References (63)

1. Bekker MH , Van Mens-Verhulst J . Anxiety disorders: Sex differences in prevalence, degree, and background, but genderneutral treatment . Gender Med 2007 ; 4 Suppl B : S178-93
2. Kessler RC , Berglund P , Demler O , Jin R , Merikangas KR , Walters EE . Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication . Archives Gen Psychiatry 2005 ; 62 : 593-602
3. Stefansson JG , Lindal E , Bjornsson JK , Guthmundsdottir A. Period prevalence rates of specifi c mental disorders in an Icelandic cohort . Soc Psychiatry Psychiatr Epidemiol 1994 ; 29 : 119-25
4. Palsson SP , Ostling S , Skoog I . The incidence of fi rst-onset depression in a population followed from the age of 70 to 85. Psychol Med 2001 ; 31 : 1159-68
5. Diver MJ , Imtiaz KE , Ahmad AM , Vora JP , Fraser WD . Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-Aged men compared with those in young men. Clin Endocrinol 2003 ; 58 : 710-7
6. Panizzon MS , Hauger R , Jacobson KC , Eaves LJ , York TP , Prom-Wormley E , et al . Genetic and environmental infl uences of daily and intra-individual variation in testosterone levels in middle-Aged men . Psychoneuroendocrinology 2013 ; 38 : 2163-72
7. Ebinger M , Sievers C , Ivan D , Schneider HJ , Stalla GK . Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?. J Psychopharmacol (Oxford) 2009; 23: 841-53
8. Zarrouf FA , Artz S , Griffi th J , Sirbu C , Kommor M . Testosterone and depression: Systematic review and meta-Analysis . J Psychiatr Pract 2009 ; 15 : 289-305
9. Stoffel-Wagner B . Neurosteroid metabolism in the human brain. Eur J Endocrinol 2001 ; 145 : 669-79
10. Rey RA , Grinspon RP , Gottlieb S , Pasqualini T , Knoblovits P , Aszpis S , et al . Male hypogonadism: An extended classifi cation based on a developmental, endocrine physiology-based approach. Andrology 2013 ; 1 : 3-16
11. Bain J . Testosterone and the aging male: To treat or not to treat?. Maturitas 2010 ; 66 : 16-22
12. Khera M , Bhattacharya RK , Blick G , Kushner H , Nguyen D , Miner MM . The effect of testosterone supplementation on depression symptoms in hypogonadal men from the Testim Registry in the US (TRiUS) . Aging Male 2012 ; 15 : 14-21
13. Calof OM , Singh AB , Lee ML , Kenny AM , Urban RJ , Tenover JL , et al . Adverse events associated with testosterone replacement in middle-Aged and older men: A meta-Analysis of randomized, placebo-controlled trials . J Gerontol Ser A Biol Sci Med Sci 2005 ; 60 : 1451-7
14. Fernandez-Balsells MM , Murad MH , Lane M , Lampropulos JF , Albuquerque F , Mullan RJ , et al . Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-Analysis . J Clin Endocrinol Metab 2010 ; 95 : 2560-75
15. McHenry J , Carrier N , Hull E , Kabbaj M . Sex differences in anxiety and depression: Role of testosterone . Front Neuroendocrinol 2014 ; 35 : 42-57
16. Mohr BA , Guay AT , O ' Donnell AB , McKinlay JB . Normal, bound and nonbound testosterone levels in normally ageing men: Results from the Massachusetts Male Ageing Study . Clin Endocrinol 2005 ; 62 : 64-73
17. Johnson JM , Nachtigall LB , Stern TA . The effect of testosterone levels on mood in men: A review . Psychosomatics 2013 ; 54 : 509-14
18. Araujo AB , Durante R , Feldman HA , Goldstein I , McKinlay JB. The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study . Psychosom Med 1998 ; 60 : 458-65
19. Booth A , Johnson DR , Granger DA . Testosterone and men ' s depression: The role of social behavior . J Health Soc Behav 1999 ; 40 : 130-40
20. Kratzik CW , Schatzl G , Lackner JE , Lunglmayr G , Brandstatter N , Rucklinger E , et al . Mood changes, body mass index and bioavailable testosterone in healthy men: Results of the Androx Vienna Municipality Study . BJU Int 2007 ; 100 : 614-8
21. Archer J . The infl uence of testosterone on human aggression. Br J Psychol (London, England: 1953) 1991 ; 82(Pt 1) : 1-28
22. Skoog I , Nilsson L , Landahl S , Steen B . Mental disorders and the use of psychotropic drugs in an 85-year-old urban population. Int Psychogeriatr 1993 ; 5 : 33-48
23. Rivier C , Rivest S . Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: Peripheral and central mechanisms. Biol Reproduct 1991 ; 45 : 523-32
24. Mastorakos G , Pavlatou M , Diamanti-Kandarakis E , Chrousos GP. Exercise and the stress system . Hormones (Athens) 2005 ; 4 : 73-89
25. Sigurdsson B , Palsson SP , Johannsson M , Olafsdottir M , Aevarsson O. Saliva cortisol and male depressive syndrome in a community study. The Sudurnesjamenn study. Nord J Psychiatry 2013; 67: 145-52
26. Markianos M , Tripodianakis J , Sarantidis D , Hatzimanolis J. Plasma testosterone and dehydroepiandrosterone sulfate in male and female patients with dysthymic disorder. J Affect Disord 2007 ; 101 : 255-8
27. Beck AT , Beamesderfer A . Assessment of depression: The depression inventory . Mod Probl Pharmacopsychiatry 1974 ; 7 : 151-69
28. Zierau F , Bille A , Rutz W , Bech P . The Gotland Male Depression Scale: A validity study in patients with alcohol use disorder . Nord J Psychiatry 2002 ; 56 : 265-71
29. Ewing JA . Detecting alcoholism . The CAGE questionnaire. JAMA 1984 ; 252 : 1905-7
30. Shores MM , Sloan KL , Matsumoto AM , Moceri VM , Felker B , Kivlahan DR . Increased incidence of diagnosed depressive illness in hypogonadal older men . Arch Gen Psychiatry 2004 ; 61 : 162-7
31. Rubin RT , Poland RE , Lesser IM . Neuroendocrine aspects of primary endogenous depression VIII. Pituitary-gonadal axis activity in male patients and matched control subjects. Psychoneuroendocrinology 1989 ; 14 : 217-29
32. Davies RH , Harris B , Thomas DR , Cook N , Read G , Riad-Fahmy D . Salivary testosterone levels and major depressive illness in men. Br J Psychiatry 1992 ; 161 : 629-32
33. Gooren L . Testosterone and the brain . J Men ' s Health Gender 2007 ; 4 : 344-51
34. Amiaz R , Seidman SN . Testosterone and depression in men . Curr Opin Endocrinol Diabet Obesity 2008 ; 15 : 278-83
35. Berglund LH , Prytz HS , Perski A , Svartberg J . Testosterone levels and psychological health status in men from a general population: The Tromso study . Aging Male 2011 ; 14 : 37-41
36. Schweiger U , Deuschle M , Weber B , Korner A , Lammers CH , Schmider J , et al . Testosterone, gonadotropin, and cortisol secretion in male patients with major depression . Psychosom Med 1999 ; 61 : 292-6
37. Carroll BJ , Curtis GC , Mendels J . Neuroendocrine regulation in depression . II. Discrimination of depressed from nondepressed patients. Arch Gen Psychiatry 1976 ; 33 : 1051-8
38. Christensen MV , Kessing LV . The hypothalamo-pituitary-Adrenal axis in major affective disorder: A review . Nord J Psychiatry 2001 ; 55 : 359-63
39. Hellhammer DH , Wust S , Kudielka BM . Salivary cortisol as a biomarker in stress research . Psychoneuroendocrinology 2009 ; 34 : 163-71
40. Holsboer F , Barden N . Antidepressants and hypothalamic-pituitary-Adrenocortical regulation . Endocr Rev 1996 ; 17 : 187-205
41. Nemeroff CB , Vale WW . The neurobiology of depression: Inroads to treatment and new drug discovery . J Clin Psychiatry 2005 ; 66 Suppl 7 : 5-13
42. Bornstein SR , Engeland WC , Ehrhart-Bornstein M , Herman JP. Dissociation of ACTH and glucocorticoids . Trends Endocrinol Metab 2008 ; 19 : 175-80
43. Sigurdsson B , Palsson SP , Johannsson M , Olafsdottir M , Aevarsson O. Saliva cortisol and male depressive syndrome in a community study. The Sudurnesjamenn study. Nord J Psychiatry 2013; 67: 145-52
44. Lindqvist D , Isaksson A , Traskman-Bendz L , Brundin L. Salivary cortisol and suicidal behaviour - A follow-up study. Psychoneuroendocrinology 2008 ; 33 : 1061-8
45. Tripodianakis J , Markianos M , Rouvali O , Istikoglou C . Gonadal axis hormones in psychiatric male patients after a suicide attempt. Eur Arch Psychiatry Clin Neurosci 2007 ; 257 : 135-9
46. Barrett-Connor E , Von Muhlen DG , Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study . J Clin Endocrinol Metab 1999 ; 84 : 573-7
47. Danel T , Vantyghem MC , Touitou Y . Responses of the steroid circadian system to alcohol in humans: Importance of the time and duration of intake . Chronobiol Int 2006 ; 23 : 1025-34
48. Sarkola T , Eriksson CJ . Testosterone increases in men after a low dose of alcohol . Alcohol Clin Exp Res 2003 ; 27 : 682-5
49. Venkat KK , Arora MM , Singh P , Desai M , Khatkhatay I. Effect of alcohol consumption on bone mineral density and hormonal parameters in physically active male soldiers . Bone 2009 ; 45 : 449-54
50. Volzke H , Aumann N , Krebs A , Nauck M , Steveling A , Lerch MM , et al . Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men . Int J Androl 2010 ; 33 : 45-53
51. Arregger AL , Contreras LN , Tumilasci OR , Aquilano DR , Cardoso EM . Salivary testosterone: A reliable approach to the diagnosis of male hypogonadism . Clin Endocrinol 2007 ; 67 : 656-62
52. McEwen BS . Protective and damaging effects of stress mediators: Central role of the brain . Dial Clin Neurosci 2006 ; 8 : 367-81
53. Fink G , Sumner B , Rosie R , Wilson H , McQueen J . Androgen actions on central serotonin neurotransmission: Relevance for mood, mental state and memory . Behav Brain Res 1999 ; 105 : 53-68
54. Sumner BE , Fink G . Testosterone as well as estrogen increases serotonin2A receptor mRNA and binding site densities in the male rat brain . Brain Res Molec Brain Res 1998 ; 59 : 205-14
55. Sigwalt AR , Budde H , Helmich I , Glaser V , Ghisoni K , Lanza S , et al . Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression . Neuroscience 2011 ; 192 : 661-74
56. Hinkelmann K , Moritz S , Botzenhardt J , Muhtz C , Wiedemann K , Kellner M , et al . Changes in cortisol secretion during antidepressive treatment and cognitive improvement in patients with major depression: A longitudinal study . Psychoneuroendocrinology 2012 ; 37 : 685-92
57. Rutz W, Walinder J, Rhimer Z, Pestality P. [Male depression - Stress reaction combined with serotonin defi ciency?.]. Lakartidningen 1999 ; 96 : 1177-8 . Manlig depression - stressreaktion kombinerad med serotoninsvaghet?.
58. Van Praag HM . Faulty cortisol/serotonin interplay . Psychopathological and biological characterisation of a new, hypothetical depression subtype (SeCA depression). Psychiatry Res 1996 ; 65 : 143-57
59. Giammanco M , Tabacchi G , Giammanco S , Di Majo D , La Guardia M . Testosterone and aggressiveness . Med Sci Monit 2005 ; 11 : RA136-45
60. Chatzittofi s A , Nordstrom P , Hellstrom C , Arver S , Asberg M , Jokinen J . CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters . Eur Neuropsychopharmacol 2013 ; 23 : 1280-7
61. Markianos M , Tripodianakis J , Istikoglou C , Rouvali O , Christopoulos M , Papageorgopoulos P , et al . Suicide attempt by jumping: A study of gonadal axis hormones in male suicide attempters versus men who fell by accident . Psychiatry Res 2009 ; 170 : 82-5
62. Kalin NH . Primate models to understand human aggression . J Clin Psychiatry 1999 ; 60 Suppl 15 : 29-32
63. Manthey L , Leeds C , Giltay EJ , Van Veen T , Vreeburg SA , Penninx BW , et al . Antidepressant use and salivary cortisol in depressive and anxiety disorders . Eur Neuropsychopharmacol 2011 ; 21 : 691-9