The Effect of Testosterone Levels on Mood in Men: A Review

Psychosomatics

Volumn 54, Issue 6, 2013, Pages 509-514

  Johnson, Justin M ^a   Nachtigall, Lisa B ^a   Stern, Theodore A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC AGENT; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ACNE; AGGRESSIVENESS; ANDROGEN DEFICIENCY; ANDROGEN THERAPY; ANGER; BIPOLAR DISORDER; DEPRESSION; DISEASE COURSE; DYSTHYMIA; EUPHORIA; GYNECOMASTIA; HAIR GROWTH; HAIR LOSS; HEMATOCRIT; HIGH RISK BEHAVIOR; HORMONE DETERMINATION; HOSTILITY; HUMAN; HYPOGONADISM; HYPOMANIA; IRRITABILITY; MAJOR DEPRESSION; MANIA; MOOD; MOOD CHANGE; MOOD DISORDER; REVIEW; SELF CONCEPT; SIDE EFFECT; SLEEP DISORDERED BREATHING; SPERMATOGENESIS; SUICIDE ATTEMPT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE;

AFFECT; BIPOLAR DISORDER; DEPRESSIVE DISORDER; HUMANS; MALE; MOOD DISORDERS; TESTOSTERONE;

EID: 84887607561     PISSN: 00333182     EISSN: 15457206     Source Type: Journal    
DOI: 10.1016/j.psym.2013.06.018     Document Type: Review

References (31)

1. Handelsman D.J. Androgen physiology, pharmacology and abuse. Endocrinology 2010, 2469-2498. Saunders Elsevier, Philadelphia, PA. 6th ed. J.L. Jameson, L.J. DeGroot (Eds.).
2. Jameson J.L., Finlayson C. Endocrinology of sexual maturation and puberty. Endocrinology 2010, 2229-2238. Saunders Elsevier, Philadelphia, PA. 6th ed. J.L. Jameson, L.J. DeGroot (Eds.).
3. Southren A.L., Tochimoto S., Carmody N.C., et al. Plasma production rates of testosterone in normal adult men and women and in patients with the syndrome of feminizing testes. J Clin Endocrinol Metab 1965, 25(11):1441-1450.
4. Southren A.L., Gordon G.G., Tochimoto S., et al. Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men and women using a constant infusion procedure: effect of time of day and plasma concentration on the metabolic clearance rate of testosterone. J Clin Endocrinol Metab 1967, 27(5):686-694.
5. Talih F., Fattal O., Malone D. Anabolic steroid abuse: psychiatric and physical costs. Cleveland Clin J Med 2007, 74:341-351.
6. Glass A.R., Swerdloff R.S., Bray G.A., et al. Low serum testosterone and sex-hormone-binding-globulin in massively obese men. J Clin Endocrinol Metab 1977, 45(6):1211-1219.
7. Purifoy F.E., Koopmans L.H., Mayes D.M. Age differences in serum androgen levels in normal adult males. Hum Biol 1981, 53(4):499-511.
8. Davidson J.M., Chen J.J., Crapo L., et al. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab 1983, 57(1):71-77.
9. Bhasin S., Cunningham G.R., Hayes F.J., et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010, 95(6):2536-2559.
10. Seidman S.N. Androgens and the aging male. Psychopharm Bull 2007, 40(4):205-218.
11. Seidman S.N., Walsh T.B. Testosterone and depression in aging men. Am J Geriatr Psychiatry 1999, 7:18-33.
12. Araujo A.B., Esche G.R., Kupelian V., et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab 2007, 92:4241-4247.
13. Bhasin S., Basaria S. Diagnosis and treatment of hypogonadism in men. Best Pract Res Clin Endocrinol Metab 2011, 25(2):251-270.
14. Zarrouff F.A., Artz S., Griffith J., et al. Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract. 15 2009, 289-305.
15. Wang C., Cunningham G., Dobs A., et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 2004, 89(5):2085-2098.
16. Sher L., Grunebaum M.F., Sullivan G.M., et al. Testosterone levels in suicide attempters with bipolar disorder. J Psych Res 2012, 46:1267-1271.
17. Bahrke M.S., Yesalis C.E., Wright J.E. Psychological and behavioural effects of endogenous testosterone and anabolic-androgenic steroids. An update. Sports Med 1996, 22(6):367-390.
18. Schiavi R.C., Theilgaard A., Owen D.R., et al. Sex chromosome anomalies, hormones and aggressivity. Arch Gen Psychiatry 1984, 41:93-99.
19. Milunsky J.M. Prenatal diagnosis of sex chromosome abnormalities. Genetic disorders and the fetus: diagnosis, prevention and treatment 2010, 273-312. Wiley-Blackwell, Oxford. 6th ed. A. Milunsky, J.M. Milunsky (Eds.).
20. O'Connor D.B., Archer J., Wu F.C. Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study. J Clin Endocrinol Metab 2004, 89(6):2837-2845.
21. Pope H.G., Katz D.L. Psychiatry and medical effects of anabolic-androgenic steroid use. A controlled study of 160 athletes. Arch Gen Psychiatry 1994, 51:375-382.
22. Amiaz R., Seidman S.N. Testosterone and depression in men. Curr Opin Endocrinol Diabetes Obes 2008, 15:278-283.
23. Burris A.S., Banks S.M., Carter C.S., et al. A long-term, prospective study of the physiologic and behavioral aspects of hormone replacement in untreated hypogonadal men. J Androl 1992, 13:297-304.
24. Wang C., Alexander G., Berman N., et al. Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study. J Clinc Endocrinol Metab 1995, 81:3578-3583.
25. Barrett-Connor E., Von Muhlen D.G., Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. J Clin Endocrinol Metab 1999, 84:573-577.
26. Booth A., Johnson D.R., Granger D.A. Testosterone and men's depression: the role of social behavior. J Health Soc Behav 1999, 40:130-140.
27. Araujo A.B., Durante R., Feldman H.A., et al. The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 1998, 60:450-465.
28. Rupprecht R., Rupprecht C., Rupprecht M., et al. Different reactivity of the hypothalamo-pituitary-gonadal-axis in depression and normal controls. Pharmacopsychiatry 1988, 21:438-439.
29. Schweiger U., Deuschle M., Weber B., et al. Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom Med 1999, 61:292-296.
30. Seidman S.N., Araujo A.B., Roose S.P., et al. Low testosterone levels in elderly men with dysthymic disorder. Am J Psychiatry. 159 2002, 456-459.
31. Seidman S.N., Weiser M. Testosterone and mood in aging men. Psychiatr Clin N Am 2013, 36:177-182.