Novel Polymorphisms in Porcine 3′UTR of the Leptin Gene, Including a Rare Variant within Target Sequence for MIR-9 Gene in Duroc Breed, not Associated with Production Traits

Animal Biotechnology

Volumn 26, Issue 2, 2015, Pages 156-163

  Mankowska, M ^a   Szydlowski, M ^a   Salamon, S ^a   Bartz, M ^a   Switonski, M ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

3 UTR; Fatness; Leptin; MicroRNA; MiR 9; Pig

Indexed keywords

AGRICULTURE; GENE EXPRESSION; MAMMALS; RNA;

ENERGY HOMEOSTASIS; FATNESS; LEPTIN; MICRORNAS; MIR-9; PRODUCTION TRAIT; REGULATORY SEQUENCES; TARGET SEQUENCES;

HORMONES;

SUIDAE; SUS;

3' UNTRANSLATED REGION; LEPTIN; MICRORNA;

3' UNTRANSLATED REGION; ANIMAL; BODY COMPOSITION; BODY WEIGHT; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETICS; POLAND; SWINE;

3' UNTRANSLATED REGIONS; ANIMALS; BODY COMPOSITION; BODY WEIGHT; FEMALE; GENETIC ASSOCIATION STUDIES; LEPTIN; MICRORNAS; POLAND; POLYMORPHISM, GENETIC; SWINE;

EID: 84911965313     PISSN: 10495398     EISSN: 15322378     Source Type: Journal    
DOI: 10.1080/10495398.2014.958612     Document Type: Article

References (25)

1. Switonski M , Stachowiak M , Cieslak J , Bartz M , Grzes M . Genetics of fat tissue accumulation in pigs: a comparative approach . J Appl Genet 2010 ; 51 : 153 – 168 .
2. Wood JD , Enser M , Fisher AV , Nute GR , Sheard PR , Richardson RI , Hughes SI , Whittington FM . Fat deposition, fatty acid composition and meat quality: a review . Meat Sci 2008 ; 78 : 343 – 358 .
3. Houseknecht KL , Portocarrero CP . Leptin and its receptors: regulators of whole-body energy homeostasis . Domest Anim Endocrinol 1998 ; 15 : 457 – 475 .
4. Sasaki S , Clutter AC , Pomp D . Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism . Mamm Genome 1996 ; 7 : 471 – 472 .
5. Bidwell CA , Ji S , Frank GR , Cornelius SG , Willis GM , Spurlock ME . Cloning and expression of the porcine obese gene . Anim Biotechnol 1997 ; 8 : 191 – 206 .
6. Dai RJ , Li N , Wu CX . Molecular cloning and analyzing of porcine obese cDNA . Acta Genet Sin 2000 ; 27 : 290 – 297 .
7. Kennes YM , Murphy BD , Pothier F , Palin MF . Characterization of swine leptin (LEP) polymorphisms and their association with production traits . Anim Genet 2001 ; 32 : 215 – 218 .
8. D′Andrea M , Pilla F , Giuffra E , Waddington D , Archibald AL . Structural analysis and haplotype diversity in swine LEP and MC4 R genes . J Anim Breed Genet 2008 ; 125 : 130 – 136 .
9. Pérez-Montarelo D , Fernández A , Folch JM , Pena RN , Ovilo C , Rodríguez C , Silió L , Fernández Al . Joint effects of porcine leptin and leptin receptor polymorphisms on productivity and quality traits . Anim Genet 2012 ; 43 : 805 – 809 .
10. Szydlowski M , Stachowiak M , Mackowski M , Kamyczek M , Eckert R , Rozycki M , Switonski M . No major effect of the leptin gene polymorphism on porcine production traits . J Anim Breed Genet 2004 ; 121 : 149 – 155 .
11. De Oliveira Peixoto J , Facioni Guimarães SE , Sávio Lopes P , Menck Soares MA , Vieira Pires A , Gualberto Barbosa MV , De Almeida Torres R , De Almeida e Silva M . Associations of leptin gene polymorphisms with production traits in pigs . J Anim Breed Genet 2006 ; 123 : 378 – 383 .
12. Urban T , Kuciel J , Mikolášová R . Polymorphism of genes encoding for ryanodine receptor, growth hormone, leptin and MYC protooncogene protein and meat production in Duroc pigs . Czech J Anim Sci 2002 ; 47 : 411 – 417 .
13. Kurył J , Kapelański W , Pierzchała M , Bocian M , Grajewska S . A relationship between genotypes at the GH and LEP loci and carcass meat and fat deposition in pigs . Anim Sci Pap Rep 2003 ; 21 : 15 – 26 .
14. Bartz M , Szydlowski M , Kociucka B , Salamon S , Jeleń HH , Switonski M . Transcript abundance of the pig stearoyl-CoA desaturase gene has no effect on fatty acid composition in muscle and fat tissues, but its polymorphism within the putative microRNA target site is associated with daily body weight gain and feed conversion . J Anim Sci 2013 ; 91 : 10 – 19 .
15. Bartz M , Kociucka B , Mankowska M , Switonski M , Szydlowski M . Transcript level of the porcine ME1 gene is affected by SNP in its 3′UTR, which is also associated with subcutaneous fat thickness . J Anim Breed Genet 2014 ; 131 : 271 – 278 .
16. Liu D , Hu Y , Yang X , Liu Y , Wei S , Jiang Y . Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene . Mol Biol Rep 2011 ; 38 : 2051 – 2057 .
17. Stachowiak M , Mackowski M , Madeja Z , Szydlowski M , Buszka A , Kaczmarek P , Rubis B , Mackowiak P , Nowak KW , Switonski M . Polymorphism of the porcine leptin gene promoter and analysis of its association with gene expression and fatness traits . Biochem Genet 2007 ; 45 : 245 – 253 .
18. Villalba D , Tor M , Vidal O , Bosch L , Reixach J , Amills M , Sànchez A , Estany J . An age-dependent association between a leptin C3469 T single nucleotide polymorphism and intramuscular fat content in pigs . Livest Sci 2009 ; 121 : 335 – 338 .
19. Jiang ZH , Gibson JP . Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds . Mamm Genome 1999 ; 10 : 191 – 193 .
20. Cieslak J , Nowacka-Woszuk J , Bartz M , Fijak-Nowak H , Grzes M , Szydlowski M , Switonski M . Association studies on the porcine RETN, UCP1, UCP3 and ADRB3 genes polymorphism with fatness traits . Meat Sci 2009 ; 83 : 551 – 554 .
21. Stachowiak M , Nowacka-Woszuk J , Szydlowski M , Switonski M . The ACACA and SREBF1 genes are promising markers for pig carcass and performance traits, but not for fatty acid content in the longissimus dorsi muscle and adipose tissue . Meat Sci 2013 ; 95 : 64 – 71 .
22. Szydlowski M , Salamon S , Grzes M , Switonski M . SNP in the 5′ flanking region of the pig FTO gene is associated with fatness in Polish Landrace . Livest Sci 2012 ; 150 : 397 – 400 .
23. Stachowiak M , Cieslak J , Skorczyk A , Nowakowska J , Szczerbal I , Szydlowski M , Switonski M . The pig CART (cocaine- and amphetamine-regulated transcript) gene and association of its microsatellite polymorphism with production traits . J Anim Breed Genet 2009 ; 126 : 37 – 42 .
24. Stachowiak M , Szydlowski M , Cieslak J , Switonski M . SNPs in the porcine PPARGC1a gene: interbreed differences and their phenotypic effects . Cell Mol Biol Lett 2007 ; 12 : 231 – 239 .
25. Stratil A , Peelman L , Van Poucke M , Cepica S . A HinfI PCR-RFLP at the porcine leptin (LEP) gene . Anim Genet 1997 ; 28 : 371 – 372 .