SNP in the 5' flanking region of the pig FTO gene is associated with fatness in Polish Landrace

Livestock Science

Volumn 150, Issue 1-3, 2012, Pages 397-400

  Szydlowski, M ^a   Salamon, S ^a   Grzes, M ^a   Switonski, M ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Fat and obesity associated gene; Fat deposition; Pig; SNP

Indexed keywords

PIERIS BRASSICAE; SUIDAE; SUS SCROFA;

EID: 84869080825     PISSN: 18711413     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.livsci.2012.09.001     Document Type: Article

References (16)

1. Du Z.Q., Fan B., Zhao X., Amoako R., Rothschild M.F. Association analyses between type 2 diabetes genes and obesity traits in pigs. Obesity 2009, 17:323-329.
2. Dvorakova V., Bartenschlager H., Stratil A., Horak P., Stupka R., Citek J., Sprysl M., Hrdlicova A., Geldermann H. Association between polymorphism in the FTO gene and growth and carcass traits in pig crosses. Genet. Sel. Evol. 2012, 44(1):13.
3. Fan B., Du Z.Q., Rothschild M.F. The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig. Anim. Biotechnol. 2009, 20:58-70.
4. Fawcett K.A., Barroso I. The genetics of obesity: FTO leads the way. Trends Genet. 2010, 26:266-274.
5. Fontanesi L., Scotti E., Buttazzoni L., Davoli R., Russo V. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs. Anim. Genet. 2009, 40:90-93.
6. Fontanesi L., Scotti E., Buttazzoni L., Dall'Olio S., Bagnato A., Lo Fiego D.P., Davoli R., Russo V. Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs. Mol. Biol. Rep. 2010, 37:461-466.
7. Fontanesi L., Russo V. Nucleotide variability and haplotype heterogeneity at the porcine fat mass and obesity-associated (FTO) gene. Anim. Genet. 2012, 10.1111/j.1365-2052.2012.02352.x.
8. Frayling T.M., Timpson N.J., Weedon M.N., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 11:889-894.
9. Huang J., Liu G., Liu Y., Yao Y., Wu K., Fang M. Splice variant identification and expression analysis of the fat mass and obesity-associated (FTO) gene in intact and castrated male pigs. DNA Cell Biol. 2010, 29:729-733.
10. Huang J., Yang Y., Liu G., Zhang J., Dong X., Bai Y., Fang M. Molecular cloning and characterization of the porcine FTO promoter and coding regions. Mol. Biol. Rep. 2011, 38:2855-2862.
11. Madsen M.B., Birck M.M., Fredholm M., Cirera S. Expression studies of the obesity candidate gene FTO in pig. Anim. Biotechnol. 2010, 21:51-63.
12. McCaffery J.M., Papandonatos G.D., Peter I., Huggins G.S., Raynor H.A., Delahanty L.M., Cheskin L.J., Balasubramanyam A., Wagenknecht L.E., Wing R.R. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am. J. Clin. Nutr. 2012, 95(6):1477-1486.
13. Peng S., Zhu Y., Xu F., Ren X., Li X., Lai M. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med. 2011, 9:71.
14. Switonski M., Stachowiak M., Cieslak J., Bartz M., Grzes M. Genetics of fat tissue accumulation in pigs: a comparative approach. J. Appl. Genet. 2010, 51:153-168.
15. Szydlowski M., Buszka A., Mackowski M., Lechniak D., Switonski M. Polymorphism of genes encoding cytokines IL6 and TNF is associated with pig fatness. Livest. Sci. 2011, 136:150-156.
16. Zhang L.F., Miao X.T., Hua X.C., Jiang X.L., Lu Y.P., Xu N.Y. Polymorphism in 5' regulatory region of the porcine fat mass and obesity associated (FTO) gene is associated with imntramuscular fat content in a Jinhua x Pietrain F2 reference population. J. Anim. Vet. Adv. 2009, 8:2329-2334.