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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5553-5557

Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition

(4) O'Reilly, Matthew C c Scott, Sarah A a Brown, H Alex a,c Lindsley, Craig W a,b,c

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b VANDERBILT UNIVERSITY MEDICAL CENTER (United States)

c VANDERBILT UNIVERSITY (United States)

Author keywords

Inhibitors; Isoform; Phosphodiesterase; Phospholipase D (PLD)

Indexed keywords

PHOSPHOLIPASE D1; PHOSPHOLIPASE D1 INHIBITOR; PHOSPHOLIPASE D2; PHOSPHOLIPASE D2 INHIBITOR; PHOSPHOLIPASE INHIBITOR; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLONE; ENZYME INHIBITOR; PHOSPHOLIPASE D; PIPERIDINE; PIPERIDINE DERIVATIVE; PROTEIN BINDING;

AEROBIC METABOLISM; AMINATION; ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC50; IN VITRO STUDY; LIVER MICROSOME; MICROWAVE IRRADIATION; NONHUMAN; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HEK293 CELL LINE; HUMAN; KINETICS; METABOLISM; MICROSOME; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BENZIMIDAZOLES; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; KINETICS; MICROSOMES; PHOSPHOLIPASE D; PIPERIDINES; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84911948267 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.11.017 Document Type: Article

Times cited : (8)

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