Improving xylitol production at elevated temperature with engineered Kluyveromyces marxianus through over-expressing transporters

Bioresource Technology

Volumn 175, Issue , 2015, Pages 642-645

  Zhang, Jia ^a,c   Zhang, Biao ^a,c   Wang, Dongmei ^a   Gao, Xiaolian ^a,b,c   Hong, Jiong ^a,c  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b University of Houston   (United States)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

CiGXF1; Elevated temperature; K. marxianus; Xylitol; Xylose

Indexed keywords

GENES; GLUCOSE; PRODUCTIVITY; XYLOSE;

CIGXF1; ELEVATED TEMPERATURE; ENGINEERED STRAINS; FED-BATCH FERMENTATION; K. MARXIANUS; KLUYVEROMYCES MARXIANUS; XYLITOL; XYLITOL PRODUCTIONS;

SUGAR SUBSTITUTES;

XYLITOL; XYLOSE; GLUCOSE; GLUCOSE TRANSPORTER; RECOMBINANT PROTEIN;

ALCOHOL; BIOENGINEERING; FERMENTATION; GENE EXPRESSION; TEMPERATURE EFFECT; YEAST;

AQUAGLYCEROPORIN GENE; ARTICLE; BIOREACTOR; BIOTRANSFORMATION; CANDIDA; FED BATCH FERMENTATION; FUNGAL STRAIN; GENE; GENE OVEREXPRESSION; GLUCOSE XYLOSE FACILITATOR GENE; HIGH TEMPERATURE PROCEDURES; KLUYVEROMYCES MARXIANUS; NONHUMAN; BATCH CELL CULTURE; BIOSYNTHESIS; DEVICES; FERMENTATION; GENETIC ENGINEERING; GENETICS; KLUYVEROMYCES; METABOLISM; MICROBIOLOGY; PROCEDURES; TEMPERATURE;

KLUYVEROMYCES MARXIANUS;

BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CANDIDA; FERMENTATION; GENETIC ENGINEERING; GLUCOSE; INDUSTRIAL MICROBIOLOGY; KLUYVEROMYCES; MONOSACCHARIDE TRANSPORT PROTEINS; RECOMBINANT PROTEINS; TEMPERATURE; XYLITOL; XYLOSE;

EID: 84911943262     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2014.10.150     Document Type: Article

References (16)

1. Abdel-Banat B.M.A., Nonklang S., Hoshida H., Akada R. Random and targeted gene integrations through the control of non-homologous end joining in the yeast Kluyveromyces marxianus. Yeast 2010, 27:29-39.
2. Choi J.H., Moon K.H., Ryu Y.W., Seo J.H. Production of xylitol in cell recycle fermentations of Candida tropicalis. Biotechnol. Lett. 2000, 22:1625-1628.
3. Guo X.X., Zhang R.H., Li Z., Dai D.Z., Li C., Zhou X.H. A novel pathway construction in Candida tropicalis for direct xylitol conversion from corncob xylan. Bioresour. Technol. 2013, 128:547-552.
4. Hickert L.R., de Souza-Cruz P.B., Rosa C.A., Ayub M.A. Simultaneous saccharification and co-fermentation of un-detoxified rice hull hydrolysate by Saccharomyces cerevisiae ICV D254 and Spathaspora arborariae NRRL Y-48658 for the production of ethanol and xylitol. Bioresour. Technol. 2013, 143:112-116.
5. Karlgren S., Pettersson N., Nordlander B., Mathai J.C., Brodsky J.L., Zeidel M.L., Bill R.M., Hohmann S. Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling. J. Biol. Chem. 2005, 280:7186-7193.
6. Ko B.S., Kim J., Kim J.H. Production of xylitol from d-xylose by a xylitol dehydrogenase gene-disrupted mutant of Candida tropicalis. Appl. Environ. Microbiol. 2006, 72:4207-4213.
7. + symporter. Biochem. J. 2006, 395:543-549.
8. Pal S., Choudhary V., Kumar A., Biswas D., Mondal A.K., Sahoo D.K. Studies on xylitol production by metabolic pathway engineered Debaryomyces hansenii. Bioresour. Technol. 2013, 147:449-455.
9. Prakash G., Varma A.J., Prabhune A., Shouche Y., Rao M. Microbial production of xylitol from d-xylose and sugarcane bagasse hemicellulose using newly isolated thermotolerant yeast Debaryomyces hansenii. Bioresour. Technol. 2011, 102:3304-3308.
10. Sun F., Chen H. Organosolv pretreatment by crude glycerol from oleochemicals industry for enzymatic hydrolysis of wheat straw. Bioresour. Technol. 2008, 99:5474-5479.
11. Wei N., Xu H., Kim S.R., Jin Y.S. Deletion of FPS1, encoding aquaglyceroporin Fps1p, improves xylose fermentation by engineered Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2013, 79:3193-3201.
12. Xiong M., Chen G., Barford J. Alteration of xylose reductase coenzyme preference to improve ethanol production by Saccharomyces cerevisiae from high xylose concentrations. Bioresour. Technol. 2011, 102:9206-9215.
13. Zhang B., Li L.L., Zhang J., Gao X.L., Wang D.M., Hong J. Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase in Kluyveromyces marxianus. J. Ind. Microbiol. Biotechnol. 2013, 40:305-316.
14. Zhang B., Zhang L., Wang D., Gao X., Hong J. Identification of a xylose reductase gene in the xylose metabolic pathway of Kluyveromyces marxianus NBRC1777. J. Ind. Microbiol. Biotechnol. 2011, 38:2001-2010.
15. Zhang J., Zhang B., Wang D.M., Gao X.L., Hong J. Xylitol production at high temperature by engineered Kluyveromyces marxianus. Bioresour. Technol. 2014, 152:192-201.
16. Zhang X., Shen Y., Shi W., Bao X. Ethanolic cofermentation with glucose and xylose by the recombinant industrial strain Saccharomyces cerevisiae NAN-127 and the effect of furfural on xylitol production. Bioresour. Technol. 2010, 101:7104-7110.