Chronic maternal vitamin B12 restriction induced changes in body composition & glucose metabolism in the Wistar rat offspring are partly correctable by rehabilitation

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Kumar, Kalle Anand ^a   Lalitha, Anumula ^a   Reddy, Umakar ^b   Chandak, Giriraj Ratan ^b   Sengupta, Shantanu ^c   Raghunath, Manchala ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYANOCOBALAMIN; FRUCTOSE BISPHOSPHATASE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; INSULIN; MALONALDEHYDE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE KINASE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIET RESTRICTION; DISEASE ASSOCIATION; ENZYME ACTIVITY; FAT FREE MASS; FEMALE; FETUS OUTCOME; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LEAN BODY WEIGHT; MALE; MATERNAL NUTRITION; MUSCLE DEVELOPMENT; MUSCLE FUNCTION; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PERCENT OF TISSUE ASSOCIATED FAT; RAT; THERAPY EFFECT; TIME TO TREATMENT; TREATMENT DURATION; VITAMIN SUPPLEMENTATION; WEIGHT GAIN; ANALYSIS; ANIMAL; BLOOD; BODY WEIGHT; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; LIVER; MALNUTRITION; METABOLISM; NEWBORN; PREGNANCY; WISTAR RAT;

RATTUS NORVEGICUS;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; BLOOD GLUCOSE; BODY COMPOSITION; BODY WEIGHT; CATALASE; FEMALE; GLUCOSE; HOMOCYSTEINE; INSULIN; LIVER; MALE; MALNUTRITION; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MODELS, ANIMAL; OXIDATIVE STRESS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PREGNANCY; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; VITAMIN B 12;

EID: 84911935577     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112991     Document Type: Article

References (66)

1. Ling CT, Chow BF (1952) Effect of vitamin B12 on the body composition of rats. J Biol Chem I98: 439-444.
2. Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23: 588S-595S.
3. Emerson G, Wurtz E, Zanetti ME (1949) Vitamin B12-a growth factor for young rats. Fed Proc 8: 381-382.
4. Bourre JM (2006) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain Part 1: Micronutrients. J Nutr Health Aging 10: 377-385.
5. Selhub J (2002) Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 6: 39-42.
6. Nelen W, Blom H, Steegers E, Den HM, Thomas C, et al. (2000) Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol 95: 519-524.
7. Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, et al. (2004) Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 151: 483-9.
8. Kalle AK, Lalitha A, Pavithra D, Padmavathi IJN, Manisha G, et al. (2013) Maternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring. J Nutr Biochem 24: 25- 31. doi:10.1016/j.jnutbio.2012.01.004.
9. Lawlor DA, George DS, Shah E (2002) Birth weight of offspring and insulin resistance in late adulthood: cross sectional survey. BMJ 325: 359. doi:http://dx. doi.org/10.1136/bmj.325.7360.359.
10. Du M, Tong J, Zhao J, Underwood KR, Zhu M, et al. (2010) Fetal programming of skeletal muscle development in ruminant animals. J Anim Sci 88: E51-E60. doi:10.2527/jas.2009-2311.
11. Venu L, Harishankar N, Prasanna TK, Raghunath M (2004a) Maternal dietary vitamin restriction increases body fat content but not insulin resistance in WNIN rat offspring up to 6 months of age. Diabetologia 47: 1493-1501.
12. Venu L, Harishankar N, Prasanna KT, Raghunath M (2004b) Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance? Eur J Endocrinol 151: 287-294.
13. Padmavathi IJN, Kishore YD, Venu L, Manisha G, Harishankar N, et al. (2009) Prenatal and perinatal zinc restriction: effects on body composition, glucose tolerance and insulin response in rat offspring. Exp Physiol 94: 761-769. doi:10.1113/expphysiol.2008.045856.
14. Padmavathi IJN, Rao KR, Venu L, Manisha G, Kalle AK, et al. (2010) Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity. Probable Underlying Mechanisms. Diabetes 59: 98-104. doi:10.2337/db09- 0779.
15. Manisha G, Sainath PB, Padmavathi IJN, Venu L, Kalle AK, et al. (2011) Maternal manganese restriction increases susceptibility to high fat diet induced dyslipidemia and altered adipose function in WNIN male rat offspring. Exp Diabetes Res 2011: 486316. (doi:10.1155/2011/486316).
16. Zhang X, Ho SM (2011) Epigenetics meets endocrinology. J Mol Endocrinol 46: R11-32.
17. Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, et al. (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. PNAS 105: 17046-49.
18. Waterland RA, Jirtle RL (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20: 63-68.
19. Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (Suppl.) 33: 245-254.
20. Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, et al. (2007) DNA methylation, insulin resistance and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. PNAS 104: 19351-19356.
21. Leeda M, Riyazi N, De Vries JIP, Jakobs C, Van Geijn HP, et al. (1998) Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. Am J Obstet Gynecol 179: 135-9.
22. Sargoor RV, Krishnaveni GV, Srinivasan K, Wills AK, Sumithra M, et al. (2010) Higher Maternal Plasma Folate but Not Vitamin B-12 Concentrations during Pregnancy Are Associated with Better Cognitive Function Scores in 9- to 10- Year-Old Children in South India. J Nutr 140: 1014-1022. doi:10.3945/jn.109.118075.
23. Panayota M, Raptis SA George D (2010) Insulin action in hyperthyroidism: A focus on muscle and adipose tissue. Endocrine Reviews 31: 663-79. doi:10.1210/er.2009-0046.
24. US Department of Health, Education and Welfare: Guide for the Care and Use of Laboratory Animals. (1985) Washington, DC, U.S. Govt. Printing Office, (NIH publ. no. 85-23).
25. Caroline EB, Mark AH (2001) Animal models and programming of the metabolic syndrome. Br Med Bull 60: 103-121. doi:10.1093/bmb/60.1.103.
26. Choi SW, Simonetta F, Haifa G, Pamela JB, Jacob S, et al. (2004) Vitamin B-12 Deficiency Induces Anomalies of Base Substitution and Methylation in the DNA of Rat Colonic Epithelium. J Nutr 134: 750-755.
27. Nuutila P, Knuuti MJ, Maki M, Laine H, Ruotsalainen U, et al. (1995) Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography. Diabetes 44: 31-36.
28. Donahue RP, Bean JA, Donahue RA, Goldberg RB, Prineas RJ (1997) Insulin response in a triethnic population: effects of sex, ethnic origin, and body fat. Miami Community Health Study. Diabetes Care 20: 1670-1676.
29. Louet JF, LeMay C, Mauvais-Jarvis F (2004) Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep 6: 180-185. DOI:10.1007/s11883-004-0030-9.
30. Morbach CA, Brans YW (1992) Determination of body composition in growing rats by total body electrical conductivity. J Pediatr Gastroenterol Nutr 14: 283-292.
31. Shantanu S, Chen H, Toqawa T, DiBello PM, Majors AK, et al. (2001) Albumin thiolate anion is an intermediate in the formation of albumin-S-Shomocysteine. J BiolChem 276: 30111-30117.
32. Geraldine FG, Helen AP (1966) Cytological studies of fiber types in skeletal muscle. A comparative study of the mammalian diaphragm. J Cell Biol 28: 333-354. Doi:10.1083/Jcb.28.2.333.
33. Wardzala LJ, Jeanrenaud B (1983) Identification of the D-glucose-inhibitable cytochalasin B binding site as the glucose transporter in rat diaphragm plasma and microsomal membranes. Biochem Biophys Acta 730: 49-56.
34. Karen LY (1999) Engagement Of The Insulin-Sensitive Pathway In The Stimulation Of Glucose Transport By A-Lipoic Acid. M. Sc. Thesis. University Of Toronto. Available at Government of Canada website: http://www. collectionscanada.gc.ca/obj/s4/f2/dsk1/tape7/PQDD-0020/MQ45881.pdf. Accessed 2014 Oct 3.
35. Kipnis DM, Cori CF (1957) Studies of tissue permeability. III. The effect of insulin on pentose uptake by the diaphragm. J Biol Chem 224: 681-693.
36. Venu L, Padmavathi IJN, Kishore YD, Bhanu NV, Rao KR, et al. (2008) Longterm effects of maternal magnesium restriction on adiposity and insulin resistance in rat pups. Obesity 16: 1270-6. doi:10.1038/oby.2008.72.
37. Pilkis SJ (1975) Glucokinase of rat liver. Methods Enzymol 42: 31-39.
38. Bucher T, Pfleiderer G (1955) Pyruvate kinase from muscle. Methods Enzymol 1: 435-440.
39. Marcus F, Rittenhouse J, Chatterjee T, Hosey MM (1982) Fructose-1, 6- bisphosphatase from rat liver. Methods Enzymol 90: 352-357.
40. Burgess SC, He T, Yan Z, Lindner J, Sherry AD, et al. (2007) Cytosolic phosphoenolpyruvatecarboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab 5: 313-20.
41. Gierow P, Jergil B (1982) Spectrophotometric method for glucose-6-phosphate phosphatase. Methods Enzymol 89: 44-47.
42. Urakawa H, Akira K, Yasuhiro S, Gabazza EC, Murashima S, et al. (2003) Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men. J Clin Endocrinol Metab 88: 4673-4676.
43. Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, et al. (2006) Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 60: 791-801. doi:10.1038/sj.ejcn.1602383.
44. Caroline LR, Mark SP, Parker L (2005) The influence of erythrocyte folate and serum vitamin B12 status on birth weight. Br J Nutr 93: 593-599.
45. Shobha R, Yajnik CS, Asawari K, Fall CHD, Margetts BM, et al. (2001) Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune maternal nutrition study. J Nutr 131: 1217-1224.
46. Usha R (2004) Nutrition and low birth weight: from research to practice. Am J ClinNutr 79: 17-21.
47. Jones AP, Friedman MI (1982) Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy. Science 215: 1518-9.
48. Smith U (2002) Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance- is insulin resistance initiated in the adipose tissue? Int. J. Obes.Relat. Metab. Disord. 26: 897-904. DOI:10.1038/sj.ijo.0802028.
49. Zhu MJ, Ford SP, Means WJ, Hess BW, Nathanielsz PW, et al. (2006) Maternal nutrient restriction affects properties of skeletal muscle in offspring. J Physiol 575: 241-250.
50. Sucharita S, Pratibha D, Tinku T, Krishnamachari S, Kurpad AV, et al. (2014) Low maternal vitamin B12 status during pregnancy is associated with reduced heart rate variability indices in young children. Matern Child Nutr 10: 226-233.
51. Lora LI, Zavaleta N, Zulema L, Anuraj HS, Caulfield LE (2008) Maternal zinc supplementation and growth in Peruvian infants. Am J Clin Nutr 88: 154-160.
52. Torrens C, Brawley L, Anthony FW, Dance CS, Rebecca U, et al. (2006) Folate Supplementation During Pregnancy Improves Offspring Cardiovascular Dysfunction Induced by Protein Restriction. Hypertension 47: 982-987.
53. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, et al. (2009) Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes. Diabetologia 52: 2350-2358.
54. Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, et al. (2008) Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 51: 29-38.
55. Krishnaveni GV, Veena SR, Winder NR, Hill JC, Noonan K, et al. (2011) Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study. Am J Clin Nutr 93: 628-35.
56. Sarbattama S, Rebecca AS (2010) Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet-Fed Rats. Diabetes 59: 3058-3065.
57. Raghunath M, Venu L, Padmavathi IJN, Kishore YD, Ganeshan M, et al. (2009) Modulation of macronutrient metabolism in the offspring by maternal micronutrient deficiency in experimental animals. Indian J Med Res 130: 655-65.
58. Casanueva E, Viteri EF (2003) Iron and Oxidative Stress in Pregnancy. J Nutr 133: 1700S-1708S.
59. Yih FL, Hsiu-Ling T, Lee YC, Chang SJ (2005) Maternal Vitamin E Supplementation Affects the Antioxidant Capability and Oxidative Status of Hatching Chicks. J Nutr 135: 2457-2461.
60. Devrim E, Tarhan I, Erquder IB, Durak I (2006) Oxidant/Antioxidant Status of Placenta, Blood, and Cord Blood Samples From Pregnant Women Supplemented With Iron. J Soc Gynecol Investig 13: 502-505. doi:10.1016/j.jsgi.2006.07.004.
61. Amy LF, Ruchira TN, Ekström EC, Rasmussen KM, Frongillo EA (2009) Micronutrient supplementation affects maternal-infant feeding interactions and maternal distress in Bangladesh. Am J Clin Nutr 90: 141-148. doi:10.3945/ajcn.2008.26817.
62. Nisreen AA, Greenwood DC, Simpson NAB, McArdle HJ, Godfrey KM, et al. (2011) Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women. Hum Reprod 26: 911-919. doi:10.1093/humrep/der005.
63. Ahmad S, Kalle AK, Trayambak B, Gourav B, Dilip Y, et al. (2013) PPAR Signalling Pathway is a Key Modulator of Liver Proteome in Pups Born to Vitamin B12 Deficient Rats. J proteomics 91: 297-308.
64. Asmita K, Kamini D, Anvita K, Pratiksha S, Preeti CG, et al. (2011) Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats. PLoS One 6: e17706. DOI:10.1371/journal.pone.0017706.
65. Ian CGW, Frances AC, Shelley EB, Sergiy D, Shakti S, et al. (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life. J Neurosci 25: 11045- 11054; doi:10.1523/JNEUROSCI.3652-05.2005.
66. Drake AJ, Walker BR (2004) The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J Endocrinol 180: 1-16.