Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5576-5580

  Zeiger, Mirco ^a   Stark, Sebastian ^a   Kalden, Elisabeth ^a   Ackermann, Bettina ^a   Ferner, Jan ^a   Scheffer, Ute ^a   Shoja Bazargani, Fatemeh ^a   Erdel, Veysel ^a   Schwalbe, Harald ^a   Göbel, Michael W ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Amidine; Guanidine; Ligand; NMR; RNA

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GUANIDINE DERIVATIVE; RNA; TRANSACTIVATOR PROTEIN; LIGAND; MOLECULAR LIBRARY; VIRUS RNA;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DECOMPOSITION; FLUOROMETRY; HUMAN IMMUNODEFICIENCY VIRUS 1; IC50; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CONFORMATION; GENETICS; HUMAN; LONG TERMINAL REPEAT; METABOLISM; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; RNA, VIRAL; SMALL MOLECULE LIBRARIES; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84911931716     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.004     Document Type: Article

References (32)

1. C. Dingwall, I. Ernberg, M.J. Gait, S.M. Green, S. Heaphy, J. Karn, A.D. Lowe, M. Singh, M.A. Skinner, and R. Valerio Proc. Natl. Acad. Sci. U.S.A. 86 1989 6925
2. K.M. Weeks, and D.M. Crothers Cell 66 1991 577
3. P. Wei, M.E. Garber, S.M. Fang, W.H. Fischer, and K.A. Jones Cell 92 1998 451
4. T.H. Tahirov, N.D. Babayeva, K. Varzavand, J.J. Cooper, S. Sedore, and D.H. Price Nature 465 2010 747
5. S. Bannwarth, and A. Gatignol Curr. HIV Res. 3 2005 61
6. M. Baba Antiviral Res. 71 2006 301
7. S. Massari, S. Sabatini, and O. Tabarrini Curr. Pharm. Des. 2013 1860 19
8. A. Krebs, V. Ludwig, J. Pfizer, G. Dürner, and M.W. Göbel Chem. Eur. J. 10 2004 544
9. V. Ludwig, A. Krebs, M. Stoll, U. Dietrich, J. Ferner, H. Schwalbe, U. Scheffer, G. Dürner, and M.W. Göbel ChemBioChem 2007 1850
10. M. Suhartono, M. Weidlich, T. Stein, M. Karas, G. Dürner, and M.W. Göbel Eur. J. Org. Chem. 2008 1608
11. J. Ferner, M. Suhartono, S. Breitung, H.R.A. Jonker, M. Henning, J. Wöhnert, M. Göbel, and H. Schwalbe ChemBioChem 10 2009 1490
12. M. Suhartono, A.E. Schneider, G. Dürner, and M.W. Göbel Synthesis 2010 293
13. C. Matsumoto, K. Hamasaki, H. Mihara, and A. Ueno Bioorg. Med. Chem. Lett. 10 2000 1857
14. F. Aboul-ela, J. Karn, and G. Varani J. Mol. Biol. 253 1995 313
15. R. Moumné, M. Catala, V. Larue, L. Micouin, and C. Tisné Biochimie 94 2012 1607
16. A. Davidson, D.W. Begley, C. Lau, and G. Varani J. Mol. Biol. 410 2011 984
17. E.E. Swayze, E.A. Jefferson, K.A. Sannes-Lowery, L.B. Blyn, L.M. Risen, S. Arakawa, S.A. Osgood, S.A. Hofstadler, and R.H. Griffey J. Med. Chem. 45 2002 3816
18. P.P. Seth, A. Miyaji, E.A. Jefferson, K.A. Sannes-Lowery, S.A. Osgood, S.S. Propp, R. Ranken, C. Massire, R. Sampath, D.J. Ecker, E.E. Swayze, and R.H. Griffey J. Med. Chem. 48 2005 7099
19. J. Parsons, M.P. Castaldi, S. Dutta, S.M. Dibrov, D.L. Wyles, and T. Hermann Nature Chem. Biol. 5 2009 823
20. L. Yu, T.K. Oost, J.M. Schkeryantz, J. Yang, D. Janowick, and S.W. Fesik J. Am. Chem. Soc. 125 2003 4444
21. N. Foloppe, I.-J. Chen, B. Davis, A. Hold, D. Morley, and R. Howes Bioorg. Med. Chem. 12 2004 935
22. K. Bodoor, V. Boyapati, V. Gopu, M. Boisdore, K. Allam, J. Miller, W.D. Treleaven, T. Weldeghiorghis, and F. Aboul-ela J. Med. Chem. 52 2009 3753
23. E.C. Johnson, V.A. Feher, J.W. Peng, J.M. Moore, and J.R. Williamson J. Am. Chem. Soc. 125 2003 15724
24. F. Chung, C. Tisné, T. Lecourt, F. Dardel, and L. Micouin Angew. Chem., Int. Ed. 46 2007 4489
25. F. Chung, C. Tisné, T. Lecourt, B. Seijo, F. Dardel, and L. Micouin Chem. Eur. J. 15 2009 7109
26. R. Moumné, V. Larue, B. Seijo, T. Lecourt, L. Micouin, and C. Tisné Org. Biomol. Chem. 8 2010 1154
27. L. Chen, E. Cressina, F.J. Leeper, A.G. Smith, and C. Abell ACS Chem. Biol. 5 2010 355
28. M. Garavís, B. López-Méndez, A. Somoza, J. Oyarzabal, C. Dalvit, A. Villasante, R. Campos-Olivas, and C. González ACS Chem. Biol. 9 2014 1559
29. Czarnik, A. W.; Mack, D. P.; Mei, H.-Y.; Moreland, D. W. PCT Int. Appl. WO 9925327 A2 19990527, 1999.
30. B. Roth, J.M. Smith, and M.E. Hultquist Jr. J. Am. Chem. Soc. 72 1950 1914
31. B. Davis, M. Afshar, G. Varani, A.I.H. Murchie, J. Karn, G. Lentzen, M. Drysdale, J. Bower, A.J. Potter, I.D. Starkey, T. Swarbrick, and F. Aboul-ela J. Mol. Biol. 336 2004 343
32. H.-Y. Mei, M. Cui, A. Heldsinger, S.M. Lemrow, J.A. Loo, K.A. Sannes-Lowery, L. Sharmeen, and A.W. Czarnik Biochemistry 37 1998 14204