Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening

ACS Chemical Biology

Volumn 9, Issue 7, 2014, Pages 1559-1566

  Garavís, Miguel ^a,d   López Méndez, Blanca ^b   Somoza, Alvaro ^c   Oyarzabal, Julen ^b   Dalvit, Claudio ^b   Villasante, Alfredo ^d   Campos Olivas, Ramón ^b   González, Carlos ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b Structural Biology and Biocomputing Programme   (Spain)

^c INSTITUTO MADRILEÑO DE ESTUDIOS AVANZADOS EN NANOCIENCIA IMDEA NANOCIENCIA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; PHENYLALANINE TRANSFER RNA; RNA; TELOMERASE; TELOMERIC REPEAT CONTAINING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; LIGAND; MOLECULAR LIBRARY;

ARTICLE; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; COMPLEX FORMATION; DISSOCIATION CONSTANT; DNA HELIX; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORINE NUCLEAR MAGNETIC RESONANCE; FRAGMENT BASED SCREENING; HIGH THROUGHPUT SCREENING; LIGAND BINDING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RNA BINDING; RNA CONFORMATION; RNA SEQUENCE; RNA SYNTHESIS; TELOMERE; THERMOSTABILITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; HALOGENATION; HUMAN; METABOLISM; MOLECULAR LIBRARY; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PHARMACOLOGY;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DRUG DISCOVERY; G-QUADRUPLEXES; HALOGENATION; HUMANS; LIGANDS; MODELS, MOLECULAR; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA; SMALL MOLECULE LIBRARIES; TELOMERE;

EID: 84904539498     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500100z     Document Type: Article

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