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Volumn 43, Issue 2, 2015, Pages 491-509

PKCε deficits in Alzheimer's disease brains and skin fibroblasts

Author keywords

Alzheimer's disease; amyloid oligomers; diagnostic assay; peripheral biomarker; PKC

Indexed keywords

AMYLOID BETA PROTEIN; OLIGOMER; PROTEIN KINASE C EPSILON; MESSENGER RNA; PROTEIN KINASE C;

EID: 84911924808     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141221     Document Type: Article
Times cited : (27)

References (38)
  • 2
    • 5344272541 scopus 로고    scopus 로고
    • A focus on thesynapse for neuroprotection in Alzheimer disease and otherdementias
    • Coleman P, Federoff H, Kurlan R (2004) A focus on thesynapse for neuroprotection in Alzheimer disease and otherdementias. Neurology 63, 1155-1162.
    • (2004) Neurology , vol.63 , pp. 1155-1162
    • Coleman, P.1    Federoff, H.2    Kurlan, R.3
  • 3
    • 33747760358 scopus 로고    scopus 로고
    • Hippocampalsynaptic loss in early Alzheimer's disease and mildcognitive impairment
    • Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampalsynaptic loss in early Alzheimer's disease and mildcognitive impairment. Neurobiol Aging 27, 1372-1384.
    • (2006) Neurobiol Aging , vol.27 , pp. 1372-1384
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Mufson, E.J.4
  • 4
    • 0025987048 scopus 로고
    • Physical basis ofcognitive alterations in Alzheimer's disease: Synaptic loss isthe major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis ofcognitive alterations in Alzheimer's disease: Synaptic loss isthe major correlate of cognitive impairment. Ann Neurol 30, 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 6
    • 33846528583 scopus 로고    scopus 로고
    • PKCsignaling deficits:A mechanistic hypothesis for the origins of Alzheimer's disease
    • Alkon DL, Sun MK, Nelson TJ (2007) PKCsignaling deficits:A mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol Sci 28, 51-60.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 51-60
    • Alkon, D.L.1    Sun, M.K.2    Nelson, T.J.3
  • 7
    • 71749109421 scopus 로고    scopus 로고
    • Reduction of betaamyloidlevels by novel protein kinase C (epsilon) activators
    • Nelson TJ, Cui C, Luo Y, Alkon DL (2009) Reduction of betaamyloidlevels by novel protein kinase C (epsilon) activators. J Biol Chem 284, 34514-34521.
    • (2009) J Biol Chem , vol.284 , pp. 34514-34521
    • Nelson, T.J.1    Cui, C.2    Luo, Y.3    Alkon, D.L.4
  • 8
    • 78651483724 scopus 로고    scopus 로고
    • PKC-activationprevents synaptic loss, A-elevation, and cognitive deficits inAlzheimer's disease transgenic mice
    • Hongpaisan J, Sun MK, Alkon DL (2011) PKC-activationprevents synaptic loss, A-elevation, and cognitive deficits inAlzheimer's disease transgenic mice. J Neurosci 31, 630-643.
    • (2011) J Neurosci , vol.31 , pp. 630-643
    • Hongpaisan, J.1    Sun, M.K.2    Alkon, D.L.3
  • 10
    • 84877075794 scopus 로고    scopus 로고
    • PKCactivation during training restores mushroom spine synapsesand memory in the aged rat
    • Hongpaisan J, Xu C, Sen A, Nelson TJ, AlkonDL (2013) PKCactivation during training restores mushroom spine synapsesand memory in the aged rat. Neurobiol Dis 55, 44-62.
    • (2013) Neurobiol Dis , vol.55 , pp. 44-62
    • Hongpaisan, J.1    Xu, C.2    Sen, A.3    Nelson, T.J.4    Alkon, D.L.5
  • 12
    • 3242757474 scopus 로고    scopus 로고
    • Differential involvement of protein kinase C alpha andepsilon in the regulated secretion of soluble amyloid precursorprotein
    • Lanni C, Mazzucchelli M, Porrello E, Govoni S, Racchi M (2004) Differential involvement of protein kinase C alpha andepsilon in the regulated secretion of soluble amyloid precursorprotein. Eur J Biochem 271, 3068-3075.
    • (2004) Eur J Biochem , vol.271 , pp. 3068-3075
    • Lanni, C.1    Mazzucchelli, M.2    Porrello, E.3    Govoni, S.4    Racchi, M.5
  • 14
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis ofAlzheimer's disease
    • TakashimaA (2006) GSK-3 is essential in the pathogenesis ofAlzheimer's disease. J Alzheimers Dis 9(3 Suppl.) , 309-317.
    • (2006) J Alzheimers Dis , vol.9 , Issue.3 , pp. 309-317
    • Takashima, A.1
  • 15
    • 0024423978 scopus 로고
    • Imaging of memory-specific changes in the distributionof protein kinase C in the hippocampus
    • Olds JL, Anderson ML, McPhie DL, Staten LD, Alkon DL (1989) Imaging of memory-specific changes in the distributionof protein kinase C in the hippocampus. Science 245, 866-869.
    • (1989) Science , vol.245 , pp. 866-869
    • Olds, J.L.1    Anderson, M.L.2    McPhie, D.L.3    Staten, L.D.4    Alkon, D.L.5
  • 16
    • 84860860029 scopus 로고    scopus 로고
    • Apolipoprotein E3(ApoE3)but not ApoE4 protects against synaptic loss throughincreased expression of protein kinase C epsilon
    • Sen A, Alkon DL, Nelson TJ (2012) Apolipoprotein E3(ApoE3) but not ApoE4 protects against synaptic loss throughincreased expression of protein kinase C epsilon. J Biol Chem 287, 15947-15958.
    • (2012) J Biol Chem , vol.287 , pp. 15947-15958
    • Sen, A.1    Alkon, D.L.2    Nelson, T.J.3
  • 18
    • 0031593610 scopus 로고    scopus 로고
    • Lymphocytes as cell model to study apoptosis inAlzheimer's disease: Vulnerability to programmed cell deathappears to be altered
    • Eckert A, Cotman CW, Zerfass R, Hennerici M, Müller WE (1998) Lymphocytes as cell model to study apoptosis inAlzheimer's disease: Vulnerability to programmed cell deathappears to be altered. J Neural Transm Suppl 54, 259-267.
    • (1998) J Neural Transm Suppl , vol.54 , pp. 259-267
    • Eckert, A.1    Cotman, C.W.2    Zerfass, R.3    Hennerici, M.4    Müller, W.E.5
  • 20
    • 0024451476 scopus 로고
    • Amyloid beta-proteindeposition in tissues other than brain in Alzheimer's disease
    • Joachim CL, Mori H, Selkoe DJ (1989) Amyloid beta-proteindeposition in tissues other than brain in Alzheimer's disease. Nature 341, 226-230.
    • (1989) Nature , vol.341 , pp. 226-230
    • Joachim, C.L.1    Mori, H.2    Selkoe, D.J.3
  • 21
    • 0028171524 scopus 로고
    • Increased beta-amyloid release and levels of amyloidprecursor protein (APP) in fibroblast cell lines from familymembers with the Swedish Alzheimer's disease APP670/671mutation
    • Johnston JA, Cowburn RF, Norgren S, Wiehager B, Venizelos N, Winblad B, Vigo-Pelfrey C, Schenk D, Lannfelt L, O'NeillC (1994) Increased beta-amyloid release and levels of amyloidprecursor protein (APP) in fibroblast cell lines from familymembers with the Swedish Alzheimer's disease APP670/671mutation. FEBS Lett 354, 274-248.
    • (1994) FEBS Lett , vol.354 , pp. 274-248
    • Johnston, J.A.1    Cowburn, R.F.2    Norgren, S.3    Wiehager, B.4    Venizelos, N.5    Winblad, B.6    Vigo-Pelfrey, C.7    Schenk, D.8    O'Neillc, L.L.9
  • 26
    • 78049326706 scopus 로고    scopus 로고
    • Saliva levels of A-42 as potential biomarker ofAlzheimer's disease: A pilot study
    • Bermejo-Pareja F, Antequera D, Vargas T, Molina JA, CarroE (2010) Saliva levels of A-42 as potential biomarker ofAlzheimer's disease: A pilot study. BMC Neurol 10, 108.
    • (2010) BMC Neurol , vol.10 , pp. 108
    • Bermejo-Pareja, F.1    Antequera, D.2    Vargas, T.3    Molina, J.A.4    Carro, E.5
  • 27
    • 33748371203 scopus 로고    scopus 로고
    • An internally controlled peripheralbiomarker for Alzheimer's disease: Erk1 and Erk2responses to the inflammatory signal bradykinin
    • Khan TK, Alkon DL (2006) An internally controlled peripheralbiomarker for Alzheimer's disease: Erk1 and Erk2responses to the inflammatory signal bradykinin. Proc Natl Acad Sci USA 103, 13203-13207.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13203-13207
    • Khan, T.K.1    Alkon, D.L.2
  • 31
    • 0037975676 scopus 로고    scopus 로고
    • Spherical aggregates of-amyloid (amylospheroid) show high neurotoxicity and activate Tauprotein kinase I/glycogen synthase kinase-3
    • Hoshi M, Sato M, Matsumoto S, Noguchi A, Yasutake K, Yoshida N, Sato K (2003) Spherical aggregates of-amyloid (amylospheroid) show high neurotoxicity and activate Tauprotein kinase I/glycogen synthase kinase-3-. Proc Natl Acad Sci USA 100, 6370-6375.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6370-6375
    • Hoshi, M.1    Sato, M.2    Matsumoto, S.3    Noguchi, A.4    Yasutake, K.5    Yoshida, N.6    Sato, K.7
  • 33
    • 84879270670 scopus 로고    scopus 로고
    • Recombinant probes forvisualizing endogenous synaptic proteins in living neurons
    • Gross GG, Junge JA, Mora RJ (2013) Recombinant probes forvisualizing endogenous synaptic proteins in living neurons. Neuron 78, 971-985.
    • (2013) Neuron , vol.78 , pp. 971-985
    • Gross, G.G.1    Junge, J.A.2    Mora, R.J.3
  • 34
    • 84881136318 scopus 로고    scopus 로고
    • Attention enhancessynaptic efficacy and the signal-to-noise ratio in neural circuits
    • Briggs F, Mangun GR, UsreyWM (2013) Attention enhancessynaptic efficacy and the signal-to-noise ratio in neural circuits. Nature 499, 476-480.
    • (2013) Nature , vol.499 , pp. 476-480
    • Briggs, F.1    Mangun, G.R.2    Usrey, W.M.3
  • 35
    • 0030813899 scopus 로고    scopus 로고
    • The roleof anchoring protein RACK1 in PKC activation in the ageingrat brain
    • Battaini F, Pascale A, Paoletti R, Govoni S (1997) The roleof anchoring protein RACK1 in PKC activation in the ageingrat brain. Trends Neurosci 20, 410-415.
    • (1997) Trends Neurosci , vol.20 , pp. 410-415
    • Battaini, F.1    Pascale, A.2    Paoletti, R.3    Govoni, S.4
  • 37
    • 0027265320 scopus 로고
    • Assessment of protein kinase C isozymes by two-site enzymeimmunoassay in human brains and changes in Alzheimer'sdisease
    • Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T (1993) Assessment of protein kinase C isozymes by two-site enzymeimmunoassay in human brains and changes in Alzheimer'sdisease. Neurology 43, 1407-1413.
    • (1993) Neurology , vol.43 , pp. 1407-1413
    • Shimohama, S.1    Narita, M.2    Matsushima, H.3    Kimura, J.4    Kameyama, M.5    Hagiwara, M.6    Hidaka, H.7    Taniguchi, T.8
  • 38
    • 0032510676 scopus 로고    scopus 로고
    • Alzheimer's-specific effects of soluble beta-amyloid on proteinkinase C-alpha and-gamma degradation in human fibroblasts
    • Favit A, Grimaldi M, Nelson TJ, Alkon DL (1998) Alzheimer's-specific effects of soluble beta-amyloid on proteinkinase C-alpha and-gamma degradation in human fibroblasts. Proc Natl Acad Sci USA 95, 5562-5567.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5562-5567
    • Favit, A.1    Grimaldi, M.2    Nelson, T.J.3    Alkon, D.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.