Aging increases the susceptivity of MSCs to reactive oxygen species and impairs their therapeutic potency for myocardial infarction

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Li, Liang ^a   Guo, Yingfei ^a   Zhai, Hongxia ^a   Yin, Yaxin ^a   Zhang, Jinjin ^a   Chen, Haiwei ^a   Wang, Lei ^a   Li, Na ^a   Liu, Runmei ^a   Xia, Yunfeng ^a  

^a First Affiliated Hospital of General Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; FOCAL ADHESION KINASE; HYDROGEN PEROXIDE; INTEGRIN; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ACUTE HEART INFARCTION; AGE DISTRIBUTION; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ADHESION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DONOR; HEART FUNCTION; HISTOLOGY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT RESPONSE; ANIMAL; DRUG EFFECTS; HEART; MESENCHYMAL STROMA CELL; METABOLISM; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; AGING; ANIMALS; APOPTOSIS; CELL ADHESION; FREE RADICAL SCAVENGERS; HEART; HYDROGEN PEROXIDE; INTEGRINS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84911921760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111850     Document Type: Article

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