Mesenchymal stem cells in the infarcted heart

Coronary Artery Disease

Volumn 16, Issue 2, 2005, Pages 93-97

  Jain, Mohit ^a   Pfister, Otmar ^b   Hajjar, Roger J ^c   Liao, Ronglih ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cell therapy; Mesenchymal stem cells; Myocardial infarction; Myocardial regeneration

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALPHA1 INTEGRIN; ALPHA2 INTEGRIN; ALPHA5 INTEGRIN; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CD14 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CD71 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; ENDOGLIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HERMES ANTIGEN; HLA ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7 RECEPTOR; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MICROSOMAL AMINOPEPTIDASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNINDEXED DRUG;

APOPTOSIS; CELL REGENERATION; COLONY FORMING UNIT F; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HUMAN; MESENCHYMAL STEM CELL TRANSPLANTATION; MUSCLE REGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW;

ANIMALS; HEART; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; REGENERATION;

EID: 15344339214     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-200503000-00003     Document Type: Review

References (46)

1. American Heart Association. Heart Disease and Stroke Statistics-2004 Update. Dallas, Texas: American Heart Association; 2003.
2. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, et al. Apoptosis in the failing human heart. N Engl J Med 1997; 336:1131-1141.
3. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 2003; 111:1497-1504.
4. Beltrami AP, Urbanek K, Kajstura J, Van SM, Finato N, Bussani R, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344:1750-1757.
5. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6:230-247.
6. Tavassoli M, Crosby WH. Transplantation of marrow to extramedullary sites. Science 1968; 161:54-56.
7. Pereira RF, Halford KW, O'Hara MD, Leeper DB, Sokolov BP, Pollard MD, et al. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci USA 1995; 92:4857-4861.
8. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci USA 1998; 95:3908-3913.
9. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 2001; 189:49-57.
10. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998; 279:1528-1530.
11. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103:697-705. This article details the development of spontaneous cardiomyocyte-like contractions in isolated marrow stromal cells treated with the DNA-methylating agent 5-azacytidine, thereby demonstrating in vitro cardiomyogenic differentiation of MSC.
12. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105:93-98. This article provides biochemical evidence for in vivo cardiomyogenic differentiation of human MSC following implantation in non-injured mouse myocardium.
13. Fukuda K. Use of adult marrow mesenchymal stem cells for regeneration of Cardiomyocytes. Bone Marrow Transplant 2003; 32(suppl 1):S25-S27.
14. Hakuno D, Fukuda K, Makino S, Konishi F, Tomita Y, Manabe T, et al. Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors. Circulation 2002; 105:380-386.
15. Xu W, Zhang X, Qian H, Zhu W, Sun X, Hu J, et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med (Maywood) 2004; 229:623-631.
16. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6:1282-1286.
17. Murry CE, Whitney ML, Reinecke H. Muscle cell grafting for the treatment and prevention of heart failure. J Card Fail 2002; 8(6 suppl):S532-S541.
18. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, et al. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation 2001; 103:1920-1927.
19. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143-147.
20. Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002; 73:1919-1925; discussion 1926. This article describes the implantation of MSC into infarcted myocardium in adult swine. MSC resulted in stable engraftment with expression of cardiac contractile proteins. Implanted cells decreased deleterious ventricular remodeling and improved diastolic function.
21. Saito T, Kuang JQ, Bittira B, Al-Khaldi A, Chiu RC. Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg 2002; 74:19-24; discussion 24.
22. Grinnemo KH, Mansson A, Dellgren G, Klingberg D, Wardell E, Drvota V, et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. J Thorac Cardiovasc Surg 2004; 127:1293-1300.
23. Wang L, Li Y, Chen J, Gautam SC, Zhang Z, Lu M, et al. Ischemic cerebral tissue and MCP-1 enhance rat bone marrow stromal cell migration in interface culture. Exp Hematol 2002; 30:831-836.
24. Min JY, Sullivan MF, Yang Y, Zhang JP, Converso KL, Morgan JP, et al. Significant improvement of heart function by co-transplantation of human mesenchymal stem cells and fetal cardiomyocytes in post-infarcted pigs. Ann Thorac Surg 2002; 74:1568-1575.
25. Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S, et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 2004; 94:678-685.
26. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114:763-776.
27. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003; 9:1195-1201.
28. Liu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, et al. Autologous stem cell transplantation for myocardial repair. Am J Physiol Heart Circ Physiol 2004; 287:H501-H511.
29. Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 2003; 108:863-868.
30. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106:1913-1918.
31. Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004; 94:92-95. This article details the use of MSC cell therapy in 69 patients undergoing percutaneous coronary intervention for acute myocardial infarction. Implantation of MSC resulted in improved post-MI cardiac function over the six-month observation period, in the absence major complications. This article provides the first evidence for the safety and efficacy of post-MI MSC cell therapy in humans.
32. Thompson CA, Nasseri BA, Makower J, Houser S, McGarry M, Lamson T, et al. Percutaneous transvenous cellular cardiomyoplasty. A novel non-surgical approach for myocardial cell transplantation. J Am Coll Cardiol 2003; 41:1964-1971.
33. Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD. Intracoronary arterial injection of mesenchymal stromal cells and micro-infarction in dogs. Lancet 2004; 363:783-784.
34. Menasche P, Hagege AA, Vilquin JT, Desnos M, Abergel E, Pouzet B, et al. Autologous skeletal myoblast transplantation for severe post-infarction left ventricular dysfunction. J Am Coll Cardiol 2003; 41:1078-1083.
35. Jaffer FA, Weissleder R. Seeing within: molecular imaging of the cardiovascular system. Circ Res 2004; 94:433-445.
36. Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999; 181:67-73.
37. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 1991; 78:55-62.
38. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992; 13:69-80.
39. Vogel W, Grunebach F, Messam CA, Kanz L, Brugger W, Buhring HJ. Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells. Haematologica 2003; 88:126-133.
40. Bruder SP, Ricalton NS, Boynton RE, Connolly TJ, Jaiswal N, Zaia J, et al. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res 1998; 13:655-663.
41. Gronthos S, Simmons PJ. The growth factor requirements of STRO-1 - positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 1995; 85:929-940.
42. Satomura K, Derubeis AR, Fedarko NS, Ibaraki-O'Connor K, Kuznetsov SA, Rowe DW, et al. Receptor tyrosine kinase expression in human bone marrow stromal cells. J Cell Physiol 1998; 177:426-438.
43. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 1998; 176:57-66.
44. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 1996; 166:585-592.
45. Prockop DJ. Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 1997; 276:71-74.
46. Jones EA, Kinsey SE, English A, Jones RA, Straszynski L, Meredith DM, et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 2002; 46:3349-3360.