TRPA1, NMDA receptors and nitric oxide mediate mechanical hyperalgesia induced by local injection of magnesium sulfate into the rat hind paw

Physiology and Behavior

Volumn 139, Issue , 2015, Pages 267-273

  Srebro, Dragana P ^a   Vučković, Sonja M ^a   Savić Vujović, Katarina R ^a   Prostran, Milica Š ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Magnesium sulfate; Nitric oxide; NMDA; Peripheral mechanical hyperalgesia; TRPA1

Indexed keywords

ARL 17477; CAMPHOR; DIZOCILPINE; MAGNESIUM SULFATE; METHYLENE BLUE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SODIUM CHLORIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; ANALGESIC AGENT; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; NOS2 PROTEIN, RAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPA1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NONHUMAN; RAT; STIMULUS; VON FREY TEST; WISTAR RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TOUCH;

ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANYLATE CYCLASE; HYPERALGESIA; MAGNESIUM SULFATE; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; PAIN THRESHOLD; RANDOM ALLOCATION; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TOUCH; TRPC CATION CHANNELS;

EID: 84911909630     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2014.11.042     Document Type: Article

References (40)

1. Na H.S., Ryu J.H., Do S.H. The role of magnesium in pain. Magnesium in the central nervous system 2011, 157-165. University of Adelaide Press, Adelaide, South Australia. R. Vink, M. Nechifor (Eds.).
2. Nechifor M. Magnesium involvement in pain. Magnes Res 2011, 24:220-222.
3. Morrison A.P., Hunter J.M., Halpern S.H., Banerjee A. Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids: a systematic review and meta-analysis. Br J Anaesth 2013, 110:702-712.
4. Vučković S.M., Savić Vujović K.R., Srebro D.P., Medić B.M., Vučetić C.S., Prostran M.Š., et al. Synergistic interaction between ketamine and magnesium in lowering body temperature in rats. Physiol Behav 2014, 127:45-53.
5. Begon S., Pickering G., Eschalier A., Dubray C. Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain. Brain Res 2000, 887:436-439.
6. Rondón L.J., Privat A.M., Daulhac L., Davin N., Mazur A., Fialip J., et al. Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain. J Physiol 2010, 588:4205-4215.
7. Lee C.H., Wen Z.H., Chang Y.C., Huang S.Y., Tang C.C., Chen WF, et al. Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N-methyl-D-aspartate (NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes. Osteoarthritis Cartilage 2009, 17(11):1485-1493.
8. Borazan H., Kececioglu A., Okesli S., Otelcioglu S. Oral magnesium lozenge reduces postoperative sore throat: a randomized, prospective, placebo-controlled study. Anesthesiology 2012, 117(3):512-518.
9. Gyires K., Torma Z. The use of the writhing test in mice for screening different types of analgesics. Arch Int Pharmacodyn Ther 1984, 267(1):131-140.
10. Bi Y., Chen H., Su J., Cao X., Bian X., Wang K. Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice. Mol Pain 2011, 7:84.
11. Coggeshall R.E., Carlton S.M. Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery. J Comp Neurol 1998, 391(1):78-86.
12. Kinkelin I., Bröcker E.B., Koltzenburg M., Carlton S.M. Localization of ionotropic glutamate receptors in peripheral axons of human skin. Neurosci Lett 2000, 283(2):149-152.
13. Freire M.A., Guimarães J.S., Leal W.G., Pereira A. Pain modulation by nitric oxide in the spinal cord. Front Neurosci 2009, 3:175-181.
14. Tanabe M., Nagatani Y., Saitoh K., Takasu K., Ono H. Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology 2009, 56:702-708.
15. Kwan K.Y., Allchorne A.J., Vollrath M.A., Christensen A.P., Zhang D.S., Woolf C.J., et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 2006, 50:277-289.
16. Zurborg S., Yurgionas B., Jira J.A., Caspani O., Heppenstall P.A. Direct activation of the ion channel TRPA1 by Ca2+. Nat Neurosci 2007, 10:277-279.
17. Hu H., Bandell M., Petrus M.J., Zhu M.X., Patapoutian A. Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 2009, 5:183-190.
18. Eid S.R., Crown E.D., Moore E.L., Liang H.A., Choong K.C., Dima S., et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 2008, 4:48.
19. McGaraughty S., Chu K.L., Perner R.J., Didomenico S., Kort M.E., Kym P.R., et al. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain 2010, 6:14.
20. Vučković S.M., Tomić M., Stepanović-Petrović R., Ugrešić N., Prostran M.S., Bošković B., et al. Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. J Pharmacol Sci 2006, 100:310-314.
21. Srebro D.P., Vučković S., Vujović K.S., Prostran M. Anti-hyperalgesic effect of systemic magnesium sulfate in carrageenan-induced inflammatory pain in rats: influence of the nitric oxide pathway. Magnes Res 2014, 27(2):77-85.
22. Agarwal A., Dhiraj S., Raza M., Pandey R., Pandey C.K., Singh P.K., et al. Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified. Can J Anaesth 2004, 51(2):130-133.
23. Ushida T., Iwatsu O., Shimo K., Tetsunaga T., Ikeuchi M., Ikemoto T., et al. Subcutaneous administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans. J Neuroinflammation 2009, 6:25.
24. Herroeder S., Schönherr M.E., De Hert S.G., Hollmann M.W. Magnesium-essentials for anesthesiologists. Anesthesiology 2011, 114(4):971-993.
25. Koltka K., Koknel-Talu G., Asik M., Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc 2011, 19(11):1884-1889.
26. Vastani N., Seifert B., Spahn D.R., Maurer K. Sensitivities of rat primary sensory afferent nerves to magnesium: implications for differential nerve blocks. Eur J Anaesthesiol 2013, 30(1):21-28.
27. Petrus M., Peier A.M., Bandell M., Hwang S.W., Huynh T., Olney N., et al. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain 2007, 3:40.
28. Wei H., Koivisto A., Saarnilehto M., Chapman H., Kuokkanen K., Hao B., et al. Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain 2011, 1523:582-591.
29. Klafke J.Z., da Silva M.A., Trevisan G., Rossato M.F., da Silva C.R., Guerra G.P., et al. Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats. Neuroscience 2012, 222:136-146.
30. Bautista D.M., Movahed P., Hinman A., Axelsson H.E., Sterner O., Högestätt E.D., et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A 2005, 102(34):12248-12252.
31. Xu H., Blair N.T., Clapham D.E. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci 2005, 25(39):8924-8937.
32. Montrucchio D.P., Có rdova M.M., Soares Santos A.R. Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels. PLoS One 2013, 8(7):e67730.
33. Kosugi M., Nakatsuka T., Fujita T., Kuroda Y., Kumamoto E. Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. J Neurosci 2007, 27(16):4443-4451.
34. Miller K.E., Hoffman E.M., Sutharshan M., Schechter R. Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms. Pharmacol Ther 2011, 130(3):283-309.
35. Traynelis S.F., Wollmuth L.P., McBain C.J., Menniti F.S., Vance K.M., Ogden K.K., et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 2010, 62(3):405-496.
36. deGroot J., Zhou S., Carlton S.M. Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation. Neuroreport 2000, 11(3):497-502.
37. Mense S., Hoheisel U. A lack of NO in the spinal cord as a possible factor for the occurrence of spontaneous pain. Schmerz 2001, 15(1):19-25.
38. Yoshida T., Inoue R., Morii T., Takahashi N., Yamamoto S., Hara Y., et al. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2006, 2(11):596-607.
39. Moore P.K., Oluyomi A.O., Babbedge R.C., Wallace P., Hart S.L. L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol 1991, 102(1):198-202.
40. Esplugues J.V. NO as a signalling molecule in the nervous system. Br J Pharmacol 2002, 135(5):1079-1095.