Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain

Brain Research

Volumn 887, Issue 2, 2000, Pages 436-439

  Begon, Sophie ^a   Pickering, Gisèle ^a   Eschalier, Alain ^a   Dubray, Claude ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Hyperalgesia; Magnesium; MK 801; Neuropathic pain

Indexed keywords

DIZOCILPINE; MAGNESIUM SULFATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; MALE; NERVE LIGATION; NEUROPATHY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

EID: 0034731564     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03028-6     Document Type: Article

References (28)

1. Further evidence for 'pain-related' behaviours in a model of unilateral peripheral mononeuropathy
2. Response of chronic neuropathic pain syndromes to ketamine: A preliminary study
3. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
4. Clinical relevance of receptor pharmacology in the nociceptive pathway
5. Novel aspects of pain management: Opioids and beyond
6. Streptozocin-induced diabetic rats: Behavioural evidence for a model of chronic pain
7. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy
8. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord
9. Magnesium sulfate injected subcutaneously suppresses autotomy in peripherally deafferented rats
10. New experimental data on the relationship between diabetes mellitus and magnesium
11. The use of the writhing test in mice for screening different types of analgesics
12. Effect of parenteral magnesium sulfate administration on excitatory amino acid receptors in the rat brain
13. Involvement of N-methyl-D-aspartate (NMDA) receptors in non-competitive NMDA receptor antagonist-induced hyperlocomotion in mice
14. The effect of intrathecal magnesium sulfate on nociception in rat acute pain models
15. 2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain
16. A clinical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes
17. A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats
18. Voltage-dependent block of magnesium of NMDA responses in spinal cord neurons
19. High dose oral dextrometrophan versus placebo in painful diabetic neuropathy and postherpetic neuralgia
20. Excitotoxic amino acids and neuropsychiatrics disorders
21. A method for measurement of analgesic activity on inflamed tissue
22. Pretreatment with MK-801, a non-competitive NMDA antagonist, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation
23. Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats
24. [3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes
25. Neuropathic pain: Aetiology, symptoms, mechanisms, and management
26. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury hypersensitivity states
27. Magnesium suppresses neuropathic pain responses in rats via a spinal site of action
28. Ethical guidelines for investigations of experimental pain in conscious animals