A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Journal of Biological Chemistry

Volumn 289, Issue 47, 2014, Pages 33020-33031

  Chung, Jon H ^a   Larsen, Andrew R ^a   Chen, Evan ^a   Bunz, Fred ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

DOWNSTREAM TARGET; HEDGEHOG SIGNALING; TUMOR SUPPRESSION;

TRANSCRIPTION;

PROTEIN P53; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; PROTEIN BINDING; PTCH53 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PTCH53 GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; BINDING SITE; COLORECTAL TUMOR; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PATHOLOGY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ERINACEIDAE;

BINDING SITES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DOWN-REGULATION; HCT116 CELLS; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84911898620     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.597203     Document Type: Article

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