A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis

Oncotarget

Volumn 4, Issue 12, 2013, Pages 2208-2211

  Chung, Jon H ^a   Bunz, Fred ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Autocrine; Colorectal cancer; Hedgehog; Patched; Vismodegib

Indexed keywords

B RAF KINASE; K RAS PROTEIN; LIGAND; SONIC HEDGEHOG PROTEIN;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER INHIBITION; CANCER PATIENT; CARCINOGENESIS; COLORECTAL CANCER; DOWNSTREAM PROCESSING; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HUMAN; LOSS OF FUNCTION MUTATION; PARACRINE SIGNALING; TRANSCRIPTION INITIATION; UPREGULATION;

CARCINOGENESIS; COLORECTAL NEOPLASMS; GENES, TUMOR SUPPRESSOR; HUMANS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 84891934100     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1651     Document Type: Article

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