Accelerated aging in schizophrenia patients: The potential role of oxidative stress

Aging and Disease

Volumn 5, Issue 4, 2014, Pages 256-262

  Okusaga, Olaoluwa O ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Accelerated aging; Free radicals; Inflammation; Oxidative stress; Schizophrenia

Indexed keywords

EID: 84911893763     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.0500256     Document Type: Review

References (62)

1. de Grey AD (2013). The desperate need for a biomedically useful definition of "aging". Rejuvenation Res,16: 89-90.
2. Flatt T (20120. A new definition of aging? Front Genet, 3: 148.
3. Rose MR. Evolutionary Biology of Aging. Oxford: Oxford University Press; 1991.
4. Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR (2008). Is Schizophrenia a Syndrome of Accelerated Aging? Schizophr Bull, 34: 1024-1032.
5. Papanastasiou E, Gaughran F, Smith S (2011). Schizophrenia as segmental progeria. J R Soc Med, 104: 475-484.
6. Jin K (2010). Modern Biological Theories of Aging. Aging Dis, 1: 72-74.
7. Flatow J, Buckley P, Miller BJ (2013). Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry, 74: 400-409.
8. Finkel T, Holbrook NJ (2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408: 239-247.
9. Laursen TM, Munk-Olsen T, Vestergaard M (2012). Life expectancy and cardiovascular mortality in persons with schizophrenia. Curr Opin Psychiatry, 25: 83-88.
10. Andrews AO, Bartels SJ, Xie H, Peacock WJ (2009). Increased risk of nursing home admission among middle aged and older adults with schizophrenia. Am J Geriatr Psychiatry, 17: 697-705
11. Loewenstein DA, Czaja SJ, Bowie CR, Harvey PD (2012). Age-associated differences in cognitive performance in older patients with schizophrenia: a comparison with healthy older adults. Am J Geriatr Psychiatry, 20: 29-40.
12. Kochunov P, Glahn DC, Rowland LM, Olvera RL, Winkler A, Yang YH et al (2013). Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression. Biol Psychiatry, 73: 482-491.
13. Cobia DJ, Smith MJ, Wang L, Csernansky JG (2012). Longitudinal progression of frontal and temporal lobe changes in schizophrenia. Schizophr Res, 139: 1-6.
14. Papanastasiou E (2013). The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review. Ther Adv Psychopharmacol, 3: 33-51.
15. Fernandez-Egea E, García-Rizo C, Miller B, Parellada E, Justicia A, Bernardo M, et al (2011). Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis. Psychosom Med, 73: 643-647.
16. Renn JH, Yang NP, Chueh CM, Lin CY, Lan TH, Chou P. Bone mass in schizophrenia and normal populations across different decades of life. BMC Musculoskelet Disord, 10:1.
17. Sugawara N, Yasui-Furukori N, Umeda T, Tsuchimine S, Fujii A, Sato Y, et al (2012). Effect of age and disease on bone mass in Japanese patients with schizophrenia. Ann Gen Psychiatry, 11:5.
18. Fernandez-Egea E, Bernardo M, Heaphy CM, Griffith JK, Parellada E, Esmatjes E, et al (2009). Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis. Schizophr Bull, 35: 437-442.
19. Maudsley H. The Pathology of Mind. 3rd ed. London: Macmillan;1979.
20. Harman D (19566). Aging: a theory based on free radical and radiation chemistry. J Gerontol, 11: 298-300.
21. Halliwell B (1989). Tell me about free radicals, doctor: a review. J R Soc Med, 82: 747-752.
22. Martínez MC, Andriantsitohaina R (2009). Reactive nitrogen species: molecular mechanisms and potential significance in health and disease. Antioxid Redox Signal, 11: 669-702.
23. McCord JM, Fridovich I (1969). Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem, 244: 6049-6055.
24. Kalyanaraman B (2013). Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. Redox Biol, 1: 244-257.
25. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, et al (2012). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 479: 232-236.
26. Ahmed EK, Rogowska-Wrzesinska A, Roepstorff P, Bulteau AL, Friguet B (2010). Protein modification and replicative senescence of WI-38 human embryonic fibroblasts. Aging Cell, 9: 252-272.
27. Jeong J, Jung Y, Na S, Jeong J, Lee E, Kim MS, et al (2011). Novel oxidative modifications in redox-active cysteine residues. Mol Cell Proteomics, 10: M110.000513.
28. Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I (2004). S-glutathionylation: from redox regulation of protein functions to human diseases. J Cell Mol Med, 8: 201-212.
29. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005). Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol, 6: 150-166.
30. Gould N, Doulias PT, Tenopoulou M, Raju K, Ischiropoulos H (2013). Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem, 288: 26473-26479.
31. Held JM, Gibson BW (2012). Regulatory control or oxidative damage? Proteomic approaches to interrogate the role of cysteine oxidation status in biological processes. Mol Cell Proteomics, 11: R111.013037.
32. Charles RL, Schröder E, May G, Free P, Gaffney PR, Wait R, et al (2007). Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue. Mol Cell Proteomics, 6:1473-1484.
33. Gems D, Doonan R (2009). Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong? Cell Cycle, 8:1681-1687.
34. Lapointe J, Hekimi S (2010).When a theory of aging ages badly. Cell Mol Life Sci, 67: 1-8.
35. Afanas'ev I (2010). Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. Aging Dis, 1: 75-88.
36. Liochev SI (2013). Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med, 60: 1-4.
37. Yan LJ, Sohal RS (1998. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci U S A, 95: 12896-12901.
38. Korotkova EI, Misini B, Dorozhko EV, Bukkel MV, Plotnikov EV, Linert W (2011). Study of OH Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia. Int J Mol Sci, 12: 401-410.
39. Herken H, Uz E, Ozyurt H, Sögüt S, Virit O, Akyol O (2001). Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia. Mol Psychiatry, 6: 66-73.
40. Dietrich-Muszalska A, Olas B (2009). Modifications of blood platelet proteins of patients with schizophrenia. Platelets, 20: 90-96.
41. Sirota P, Gavrieli R, Wolach B (2003). Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: Parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity. Psychiatry Res, 121:123-132.
42. Do KQ, Trabesinger AH, Kirsten-Krüger M, Lauer CJ, Dydak U, Hell D, et al. (2000). Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci, 12: 3721-3728.
43. Yao JK, Leonard S, Reddy RD (2004). Increased nitric oxide radicals in postmortem brain from patients with schizophrenia. Schizophr Bull, 30: 923-934.
44. Chowdari KV, Bamne MN, Nimgaonkar VL (2011). Genetic association studies of antioxidant pathway genes and schizophrenia. Antioxid Redox Signal, 15: 2037-2045.
45. Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, et al. (2008). N-acetyl cysteine as a glutathione precursor for schizophrenia- a double-blind, randomized, placebo-controlled trial. Biol Psychiatry, 64: 361-368.
46. Palaniswamy KS, Vishwanadha VP, Ramalingam Singaravelu S (2013). Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats. Cell Stress Chaperones. [Epub ahead of print].
47. Torrey EF, Davis JM (2012). Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas. Clin Schizophr Relat Psychoses, 5: 208-216.
48. Miller B, Buckley P, Seabolt W, Mellor A, Kirkpatrick B (2011). Metaanalysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry, 70: 663-671.
49. Miller BJ, Gassama B, Sebastian D, Buckley P, Mellor A (2013). Meta-analysis of lymphocytes in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry, 73: 993-999.
50. Bitanihirwe BK, Woo TU (2011). Oxidative stress in schizophrenia: An integrated approach. Neurosci Biobehav Rev, 35: 878-893.
51. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, et al (2007). Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev, 21:1909-1920.
52. Corda S, Laplace C, Vicaut E, Duranteau J (2001). Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol, 24:762-768.
53. Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, et al (2013). Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. BMC Infect Dis, 13: 358.
54. Nathan C, Cunningham-Bussel A (2013). Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol, 13: 349-361.
55. Latz E, Xiao TS, Stutz A (2013). Activation and regulation of the inflammasomes. Nat Rev Immunol, 13: 397-411.
56. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010). Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biol. Med, 49: 1603-1616.
57. Rawdin BJ, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y, et al (2013). Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun, 31: 143-152.
58. Stadtman ER (2006). Protein oxidation and aging. Free Radical Research, 40:1250-1258.
59. Rucci A, Ensinck MA, Mufarrege N, Cotorruelo C, Borrás SG, Racca L, et al (2010). Modifications of band 3 and oxidation level of membrane proteins in senescent erythrocytes. Clin Biochem, 43: 1171-1173.
60. Muteliefu G, Shimizu H, Enomoto A, Nishijima F, Takahashi M, Niwa T (2012). Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. Am J Physiol Cell Physiol, 303:C126-134.
61. Dietrich-Muszalska A, Olas B, Rabe-Jablonska J (2005). Oxidative stress in blood platelets from schizophrenic patients. Platelets, 16:386-391.
62. Jorgensen A, Broedbaek K, Fink-Jensen A, Knorr U, Greisen Soendergaard M, Henriksen T (2013). Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res, 209: 417-23.