Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: A test of the accelerated aging hypothesis

Psychosomatic Medicine

Volumn 73, Issue 8, 2011, Pages 643-647

  Fernandez Egea, Emilio ^a,b,c   García Rizo, Clemente ^c,d   Miller, Brian ^f,g   Parellada, Eduard ^c,d,f,g   Justicia, Azucena ^c   Bernardo, Miguel ^c,d,e   Kirkpatrick, Brian ^h  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^c Hospital Clinic   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

^f INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^g UNIVERSITY OF BARCELONA   (Spain)

^h TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

aging; androgen; first episode; schizophrenia; senescence; sex hormone

Indexed keywords

ANDROGEN; TESTOSTERONE;

ADULT; AGING; ARTICLE; BODY MASS; CONTROLLED STUDY; DEPRESSION; DISORIENTATION; EGO; FAMILY HISTORY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; NONAFFECTIVE PSYCHOSIS; PRIORITY JOURNAL; PSYCHOSIS; SMOKING; SOCIOECONOMICS; TESTOSTERONE BLOOD LEVEL;

EID: 80053908854     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e318230343f     Document Type: Article

References (38)

1. Picchioni MM, Murray RM. Schizophrenia. BMJ 2007;335:91-5. (Pubitemid 47123289)
2. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 2001;60:5-20. (Pubitemid 34123501)
3. Chen JH, Hales CN, Ozanne SE. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res 2007;35: 7417-28.
4. Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR. Is schizophrenia a syndrome of accelerated aging? Schizophr Bull 2008;34: 1024-32.
5. Fernandez-Egea E, Bernardo M, Heaphy CM, Griffith JK, Parellada E, Esmatjes E, Conget I, Nguyen L, George V, Stöppler H, Kirkpatrick B. Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis. Schizophr Bull 2009;35: 437-42.
6. Fernandez-Egea E, Bruna A, Garćýa-Rizo C, Bernardo M, Kirkpatrick B. Stem cell signaling in newly diagnosed, antipsychotic-naive subjects with nonaffective psychosis. Mol Psychiatry 2009;14:989-91.
7. Ratajczak MZ, Zuba-Surma E, Kucia M, Reca R, Wojakowski W, Ratajczak J. The pleiotropic effects of the SDF-1YCXCR4 axis in organ-ogenesis, regeneration and tumorigenesis. Leukemia 2006;20:1915-24. (Pubitemid 44614878)
8. Fernandez-Egea E, Bernardo M, Donner T, Conget I, Parellada E, Justicia A, Esmatjes E, Garćýa-Rizo C, Kirkpatrick B. Metabolic profile of anti-psychotic-naive individuals with non-affective psychosis. Br J Psychiatry 2009;194:434-8.
9. Fernandez-Egea E, Bernardo M, Parellada E, Justicia A, Garćýa-Rizo C, Esmatjes E, Conget I, Kirkpatrick B. Glucose abnormalities in the siblings of people with schizophrenia. Schizophr Res 2008;103:110-3.
10. Fernandez-Egea E, Miller B, Bernardo M, Donner T, Kirkpatrick B. Parental history of Type 2 diabetes in patients with nonaffective psychosis. Schizophr Res 2008;98:302-6. (Pubitemid 350245597)
11. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-76. (Pubitemid 41428540)
12. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 2002; 87:589-98. (Pubitemid 34158223)
13. Simm A, Nass N, Bartling B, Hofmann B, Silber R-E, Navarrete Santos A. Potential biomarkers of ageing. Biol Chem 2008;389:257-65. (Pubitemid 351329032)
14. Lichtermann D, Karbe E, Maier W. The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur Arch Psychiatry Clin Neurosci 2000;250:304-10. (Pubitemid 32002384)
15. Rosenberg SD, Drake RE, Wolford GL, Mueser KT, Oxman TE, Vidaver RM, Carrieri KL, Luckoor R. Dartmouth Assessment of Lifestyle Instru-ment (DALI): a substance use disorder screen for people with severe mental illness. Am J Psychiatry 1998;155:232-8. (Pubitemid 28074286)
16. Hollingshead A, Redlich S. Social Class and Mental Illness. New York, NY: Wiley; 1958.
17. Bernardo M, Fernandez-Egea E, Torras A, Gutierrez F, Ahuir M, Arango C. Adaptation and validation into Spanish of Schedule for the Deficit Syndrome [in Spanish]. Med Clin (Barc) 2007;129:91-3. (Pubitemid 47394709)
18. Cuesta MJ, Peralta V. Psychopathological dimensions in schizophrenia. Schizophr Bull 1995;21:473-82.
19. Levine SZ, Rabinowitz J. Revisiting the 5 dimensions of the Positive and Negative Syndrome Scale. J Clin Psychopharmacol 2007;27:431-6. (Pubitemid 47415039)
20. Tang YJ, Lee WJ, Chen YT, Liu PH, Lee MC, Sheu WHH. Serum testosterone level and related metabolic factors in men over 70 years old. J Endocrinol Invest 2007;30:451-8. (Pubitemid 47496453)
21. Ko YH, Jung SW, Joe SH, Lee CH, Jung HG, Jung IK, Kim SH, Lee MS. Association between serum testosterone levels and the severity of negative symptoms in male patients with chronic schizophrenia. Psychoneur-oendocrinology 2007;32:385-91.
22. Akhondzadeh S, Rezaei F, Larijani B, Nejatisafa AA, Kashani L, Abbasi SH. Correlation between testosterone, gonadotropins and prolactin and severity of negative symptoms in male patients with chronic schizophrenia. Schizophr Res 2006;84:405-10.
23. Huber TJ, Tettenborn C, Leifke E, Emrich HM. Sex hormones in psychotic men. Psychoneuroendocrinology 2005;30:111-4. (Pubitemid 39195051)
24. Ozcan ME, Banoglu R. Gonadal hormones in schizophrenia and mood disorders. Eur Arch Psychiatry Clin Neurosci 2003;253:193-6. (Pubitemid 37203966)
25. Cesková E, Prikryl R, Kaspárek T. Testosterone in first-episode schizophrenia. Neuro Endocrinol Lett 2007;28:811-4.
26. Goyal RO, Sagar R, Ammini AC, Khurana ML, Alias AG. Negative correlation between negative symptoms of schizophrenia and testosterone levels. Ann N Y Acad Sci 2004;1032:291-4. (Pubitemid 40298497)
27. Räsänen P, Hakko H, Visuri S, Paanila J, Kapanen P, Suomela T, Tiihonen J. Serum testosterone levels, mental disorders and criminal behaviour. Acta Psychiatr Scand 1999;99:348-52. (Pubitemid 29207380)
28. Shirayama Y, Hashimoto K, Suzuki Y, Higuchi T. Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia. Schizophr Res 2002;58:69-74. (Pubitemid 35287285)
29. Taherianfard M, Shariaty M. Evaluation of serum steroid hormones in schizophrenic patients. Indian J Med Sci 2004;58:3-9. (Pubitemid 41646736)
30. Saad F, Gooren L. The role of testosterone in the metabolic syndrome: a review. J Steroid Biochem Mol Biol 2009;114:40-3.
31. Goncharov NP, Katsya GV, Chagina NA, Gooren LJ. Three definitions of metabolic syndrome applied to a sample of young obese men and their relation with plasma testosterone. Aging Male 2008;11:118-22.
32. Nachshoni T, Ebert T, Abramovitch Y, Assael-Amir M, Kotler M, Maayan R, Weizman A, Strous RD. Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsy-chotic treated schizophrenia patients: a randomized, double-blind placebo controlled trial. Schizophr Res 2005;79:251-6. (Pubitemid 41457265)
33. Strous RD, Maayan R, Lapidus R, Stryjer R, Lustig M, Kotler M, Weizman A. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60:133-41. (Pubitemid 36173119)
34. Elias A, Kumar A. Testosterone for schizophrenia. Cochrane Database Syst Rev 2007;CD006197.
35. Almeida OP, Yeap BB, Hankey GJ, Jamrozik K, Flicker L. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry 2008;65:283-9. (Pubitemid 351342444)
36. Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and Type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 2008;31:2383-90.
37. Tang B, Chang WL, Lanigan CM, Dean B, Sutcliffe JG, Thomas EA. Normal human aging and early-stage schizophrenia share common molecular profiles. Aging Cell 2009;8:339-42.
38. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007;64:1123-31. (Pubitemid 47529346)