Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16359-16364

  Gong, Bei ^a   Shin, Minsang ^a   Sun, Jiali ^a   Jung, Che Hun ^a   Bolt, Edward L ^b   Van Der Oost, John ^c   Kim, Jeong Sun ^a  

^a Chonnam National University   (South Korea)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Bacterial immunity; Cas proteins; Cas3; Cascade; CRISPR

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; METAL ION; NUCLEASE HELICASE CAS3; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL RNA; CRISPR ASSOCIATED PROTEIN; DEOXYRIBONUCLEASE; DNA; DNA HELICASE; HYBRID PROTEIN; MAGNESIUM; MANGANESE; PROTEIN BINDING; SINGLE STRANDED DNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL IMMUNITY; BACTERIUM; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRISPR CAS SYSTEM; CRYSTAL STRUCTURE; DNA INTERFERENCE; DNA STRAND; ENZYME MECHANISM; GENETIC REGULATION; NONHUMAN; THERMOBACULUM TERRENUM; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INTERSPERSED REPEAT; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); THERMOBACULUM TERRENUM;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIA; BACTERIAL PROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASES; DNA; DNA HELICASES; DNA, BACTERIAL; DNA, SINGLE-STRANDED; HOST-PATHOGEN INTERACTIONS; INTERSPERSED REPETITIVE SEQUENCES; MAGNESIUM; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, BACTERIAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84911890147     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410806111     Document Type: Article

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