Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors

Molecular and Cellular Biochemistry

Volumn 397, Issue 1-2, 2014, Pages 267-276

  Chen, Chunyan ^a   Han, Xinyuan ^b   Fan, Fenling ^a   Liu, Ya ^a   Wang, Tingzhong ^a   Wang, Juanjuan ^a   Hu, Peijing ^a   Ma, Aiqun ^a   Tian, Hongyan ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

Author keywords

Activation; Pulmonary artery adventitial fibroblasts; Serotonin; TGF 1 Smad3

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; ALPHA SMOOTH MUSCLE ACTIN; CONNECTIVE TISSUE GROWTH FACTOR; KETANSERIN; MESSENGER RNA; NEUTRALIZING ANTIBODY; PROTEIN ANTIBODY; SCLEROPROTEIN; SEROTONIN; SEROTONIN 2A RECEPTOR; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CTGF PROTEIN, RAT; MADH3 PROTEIN, RAT; SEROTONIN ANTAGONIST; TGFB1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; FIBROGENESIS; LUNG FIBROBLAST; LUNG FIBROSIS; MALE; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY ARTERY ADVENTITIAL FIBROBLAST; PULMONARY ARTERY ADVENTITIAL FIBROSIS; RAT; ADVENTITIA; ANIMAL; DRUG EFFECTS; FIBROBLAST; FIBROSIS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ADVENTITIA; ANIMALS; CELL PROLIFERATION; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBROSIS; HYPERTENSION, PULMONARY; KETANSERIN; MALE; PHOSPHORYLATION; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84911863805     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2194-0     Document Type: Article

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