Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment

Journal of Controlled Release

Volumn 197, Issue , 2015, Pages 138-147

  Wang, Xiaoling ^a   Sng, Ming Keat ^a   Foo, Selin ^a   Chong, Han Chung ^a   Lee, Wei Li ^b   Tang, Mark Boon Yang ^c   Ng, Kee Woei ^b   Luo, Baiwen ^b   Choong, Cleo ^b   Wong, Marcus Thien Chong ^d   Tong, Benny Meng Kiat ^e   Chiba, Shunsuke ^e   Loo, Say Chye Joachim ^b   Zhu, Pengcheng ^a   Tan, Nguan Soon ^a,f  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL SKIN CENTRE   (Singapore)

^d TAN TOCK SENG HOSPITAL   (Singapore)

^e Nanyang Technological University   (Singapore)

^f INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Controlled release; Diabetic wound healing; GW501516; Hydrogen peroxide; Microparticle; Peroxisome proliferator activated receptor beta delta

Indexed keywords

CELL CULTURE; FUNCTIONAL POLYMERS; HYDROGEN PEROXIDE; TARGETED DRUG DELIVERY; TISSUE REGENERATION;

CONTROLLED RELEASE; DIABETIC WOUNDS; GW501516; MICRO PARTICLES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR;

CONTROLLED DRUG DELIVERY;

CATALASE; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; POLYLACTIDE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; COLLAGEN; DELAYED RELEASE FORMULATION; GLUTATHIONE PEROXIDASE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER; REACTIVE OXYGEN METABOLITE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC WOUND; EXTRACELLULAR MATRIX; FIBROBLAST; KERATINOCYTE; MALE; MICROENCAPSULATION; MICROENVIRONMENT; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN EXPRESSION; WOUND CLOSURE; WOUND HEALING; AGONISTS; ANIMAL; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; SCANNING ELECTRON MICROSCOPY;

ANIMALS; CATALASE; CELLS, CULTURED; COLLAGEN; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS; DRUG DELIVERY SYSTEMS; FIBROBLASTS; GLUTATHIONE PEROXIDASE; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; LACTIC ACID; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; OXIDATION-REDUCTION; POLYGLYCOLIC ACID; POLYMERS; PPAR DELTA; PPAR-BETA; REACTIVE OXYGEN SPECIES; THIAZOLES; WOUND HEALING;

EID: 84911488199     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.11.001     Document Type: Article

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