Fabrication and drug release study of double-layered microparticles of various sizes

Journal of Pharmaceutical Sciences

Volumn 101, Issue 8, 2012, Pages 2787-2797

  Lee, Wei Li ^a   Seh, Yi Chuan ^a   Widjaja, Effendi ^b   Chong, Han Chung ^c   Tan, Nguan Soon ^c   Joachim Loo, Say Chye ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Biodegradable polymers; Controlled release; Microparticles; Multilayers; Particle size; Polymeric drug delivery systems; Solvent evaporation

Indexed keywords

METOCLOPRAMIDE; POLYGLACTIN; POLYLACTIDE; POLYVINYL ALCOHOL;

ACCELERATION; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; DRUG DEGRADATION; DRUG RELEASE; ENCAPSULATION; EVAPORATION; HYDROLYSIS; HYDROPHILICITY; MOLECULAR WEIGHT; MORPHOLOGY; PARTICLE SIZE; PHASE SEPARATION; SCANNING ELECTRON MICROSCOPY;

EID: 84862834777     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23191     Document Type: Article

References (33)

1. Freiberg S, Zhu X. 2004. Polymer microspheres for controlled drug release. Int J Pharm 282(1-2):1-18.
2. Lu Y, Chen SC. 2004. Micro and nano-fabrication of biodegradable polymers for drug delivery. Adv Drug Deliv Rev 56(11):1621-1633.
3. Jalil R, Nixon JR. 1990. Microencapsulation using poly(l-lactic acid) IV: Release properties of microcapsules containing phenobarbitone. J Microencapsul 7(1):53-66.
4. Lee TH, Wang JJ, Wang CH. 2002. Double-walled microspheres for the sustained release of a highly water soluble drug: Characterization and irradiation studies. J Control Release 83(3):437-452.
5. Rahman NA, Mathiowitz E. 2004. Localization of bovine serum albumin in double-walled microspheres. J Control Release 94(1):163-175.
6. Kokai LE, Tan H, Jhunjhunwala S, Little SR, Frank JW, Marra KG. 2010. Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres. J Control Release 141(2):168-176.
7. Shi M, Yang YY, Chaw CS, Goh SH, Moochhala SM, Ng S, Heller J. 2003. Double walled POE/PLGA microspheres: Encapsulation of water-soluble and water-insoluble proteins and their release properties. J Control Release 89(2):167-177.
8. Naraharisetti PK, Ning Lew MD, Fu YC, Lee DJ, Wang CH. 2005. Gentamicin-loaded discs and microspheres and their modifications: Characterization and in vitro release. J Control Release 102(2):345-359.
9. Sheikh Hassan A, Sapin A, Lamprecht A, Emond E, El Ghazouani F, Maincent P. 2009. Composite microparticles with in vivo reduction of the burst release effect. Eur J Pharm Biopharm 73(3):337-344.
10. Khung YL, Lee WL, Chui KL, Liu Y, Lim MP, Huang CL, Loo SCJ. 2012. Microencapsulation of dye- and drug-loaded particles for imaging and controlled release of multiple drugs. Adv Healthcare Mater 1:159-163.
11. Lee WL, Loei C, Widjaja E, Loo SCJ. 2011. Altering the drug release profiles of double-layered ternary-phase microparticles. J Control Release 151:229-238.
12. Tan EC, Lin RY, Wang CH. 2005. Fabrication of double-walled microspheres for the sustained release of doxorubicin. J Colloid Interface Sci 291(1):135-143.
13. Lee WL, Yu P, Hong M, Widjaja E, Loo SCJ. 2012. Designing multilayered particulate systems for tunable drug release profiles. Acta Biomater [Epub ahead of print.]
14. Schoubben A, Blasi P, Giovagnoli S, Perioli L, Rossi C, Ricci M. 2009. Novel composite microparticles for protein stabilization and delivery. Eur J Pharm Sci 36(2-3):226-234.
15. Berkland C, Pollauf E, Pack DW, Kim K. 2004. Uniform double-walled polymer microspheres of controllable shell thickness. J Control Release 96(1):101-111.
16. Dass CR, Burton MA. 1999. Microsphere-mediated targeted gene therapy of solid tumors. Drug Deliv 6(4):243-252.
17. Philipson K, Falk R, Svartengren M, Jarvis N, Bailey M, Bergmann R, Hofmann W, Camner P. 2000. Does lung retention of inhaled particles depend on their geometric diameter? Exp Lung Res 26(6):437-455.
18. Berkland C, Cox A, Kim K, Pack DW. 2004. Three-month, zero-order piroxicam release from monodispersed double-walled microspheres of controlled shell thickness. J Biomed Mater Res 70A(4):576-584.
19. Klose D, Siepmann F, Elkharraz K, Siepmann J. 2008. PLGA-based drug delivery systems: Importance of the type of drug and device geometry. Int J Pharm 354(1-2):95-103.
20. Lee WL, Foo WL, Widjaja E, Loo SCJ. 2010. Manipulation of process parameters to achieve different ternary-phase microparticle configurations. Acta Biomater 6:1342-1352.
21. Wang Y, Guo BH, Wan X, Xu J, Wang X, Zhang YP. 2009. Janus-like polymer particles prepared via internal phase separation from emulsified polymer/oil droplets. Polymer 50(14):3361-3369.
22. Yavagal DR, Karnad DR, Oak JL. 2000. Metoclopramide for preventing pneumonia in critically ill patients receiving enteral tube feeding: A randomized controlled trial. Crit Care Med 28(5):1408-1411.
23. Lee WL, Widjaja E, Loo SCJ. 2010. One-step fabrication of triple-layered polymeric microparticles with layer localization of drugs as a novel drug-delivery system. Small 6:1003-1011.
24. Lee WL, Hong M, Widjaja E, Loo SCJ. 2010. Formation and degradation of biodegradable triple-layered microparticles. Macromol Rapid Commun 31:1193-1200.
25. Chen JL, Yeh MK, Chiang CH. 2004. The mechanism of surface-indented protein-loaded PLGA microparticle formation: The effects of salt (NaCl) on the solidification process. J Microencapsul 21(8):877-888.
26. Yeh MK, Chen JL, Chiang CH. 2002. Vibrio cholerae-loaded poly(dl-lactide-co-glycolide) microparticles. J Microencapsul 19(2):203-212.
27. Widjaja E, Lee WL, Loo SCJ. 2010. Application of Raman microscopy to biodegradable double-walled microspheres. Anal Chem 82:1277-1282.
28. Freitas S, Merkle HP, Gander B. 2005. Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology. J Control Release 102(2):313-332.
29. Katou H, Wandrey AJ, Gander B. 2008. Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication. Int J Pharm 364(1):45-53.
30. Visscher GE, Robison RL, Maulding HV, Fong JW, Pearson JE, Argentieri GJ. 1985. Biodegradation of and tissue reaction to 50:50 poly(dl-lactide-co-glycolide) microcapsules. J Biomed Mater Res 19(3):349-365.
31. Mao SR, Shi Y, Li L, Xu J, Schaper A, Kissel T. 2008. Effects of process and formulation parameters on characteristics and internal morphology of poly(d, l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm 68(2):214-223.
32. Mainardes RM, Evangelista RC. 2005. PLGA nanoparticles containing praziquantel: Effect of formulation variables on size distribution. Int J Pharm 290(1-2):137-144.
33. Rosca ID, Watari F, Uo M. 2004. Microparticle formation and its mechanism in single and double emulsion solvent evaporation. J Control Release 99(2):271-280.