In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy

Journal of Controlled Release

Volumn 197, Issue , 2015, Pages 121-130

  Karrout, Y ^a,b   Dubuquoy, L ^c   Piveteau, C ^a,d,e,f   Siepmann, F ^a,b   Moussa, E ^a,b   Wils, D ^g   Beghyn, T ^a,d,e,f   Neut, C ^a,c   Flament, M P ^a,b   Guerin Deremaux, L ^g   Dubreuil, L ^a,c   Deprez, B ^a,d,e,f   Desreumaux, P ^a,c   Siepmann, J ^a,b  

^a UNIV LILLE   (France)

^b CHU de Lille   (France)

^c UNIVERSITÉ DE LILLE   (France)

^d INSERM   (France)

^e INSTITUT PASTEUR DE LILLE   (France)

^f PRIM Pôle de Recherche Interdisciplinaire sur le Médicament   (France)

^g Roquette   (France)

Author keywords

5 aminosalicylic acid; Colon targeting; Film coatings; In vivo efficacy; Inflammatory bowel diseases

Indexed keywords

ACTIVATION ANALYSIS; CHEMICAL ACTIVATION; COATINGS; DISEASES; DRUG DOSAGE; DRUG PRODUCTS; GENES; PATHOLOGY; PLANTS (BOTANY); POLYMERASE CHAIN REACTION; RATS; STARCH;

5-AMINOSALICYLIC ACIDS; COLON TARGETING; FILM COATINGS; IN-VIVO; INFLAMMATORY BOWEL DISEASE;

PELLETIZING;

ETHYL CELLULOSE; INTERLEUKIN 1BETA; MESALAZINE; MESSENGER RNA; MYELOPEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYSACCHARIDE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR; CELLULOSE; DEXTRIN; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; NUTRIOSE; PEROXIDASE; STARCH; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFICACY; DRUG RELEASE; DRUG TARGETING; EXPERIMENTAL COLITIS; FILM COATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; COLITIS; COLON; DRUG DELIVERY SYSTEM; GENETICS; METABOLISM; MICROFLORA; TRANSGENIC MOUSE; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLULOSE; COLITIS; COLON; DEXTRINS; DRUG DELIVERY SYSTEMS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; INTERLEUKIN-1BETA; MALE; MESALAMINE; MICE, TRANSGENIC; MICROBIOTA; PEROXIDASE; PPAR GAMMA; RATS, WISTAR; RNA, MESSENGER; STARCH; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84911486858     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.11.006     Document Type: Article

References (31)

1. P. Desreumaux, and S. Ghosh Mode of action and delivery of 5-aminosalicylic acid - new evidence Aliment. Pharmacol. Ther. 24 2006 2 9
2. C. Rousseaux, B. Lefebvre, L. Dubuquoy, P. Lefebvre, O. Romano, J. Auwerx, D. Metzger, W. Wahli, B. Desvergne, G.C. Naccari, P. Chavatte, A. Farce, P. Bulois, A. Cortot, J.-F. Colombel, and P. Desreumaux Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-γ J. Exp. Med. 201 2005 1205 1215
3. P. Desreumaux, L. Dubuquoy, S. Nutten, M. Peuchmaur, W. Englaro, K. Schoonjans, B. Derijard, B. Desvergne, W. Wahli, P. Chambon, M.D. Leibowitz, J.F. Colombel, and Johan Auwerx Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies J. Exp. Med. 193 2001 827 838
4. L. Dubuquoy, C. Rousseaux, X. Thuru, L. Peyrin-Biroulet, O. Romano, P. Chavatte, M. Chamaillard, and P. Desreumaux PPARγ as a new therapeutic target in inflammatory bowel diseases Gut 55 2006 1341 1349
5. A. Maroni, M.D.D. Curto, L. Zema, A. Foppoli, and A. Gazzaniga Film coatings for oral colon targeting Int. J. Pharm. 457 2013 372 394
6. F.J.O. Varum, G.B. Hatton, A.C. Freire, and A.W. Basit A novel coating concept for ileo-colonic drug targeting: proof of concept in humans using scintigraphy Eur. J. Pharm. Biopharm. 84 2013 573 577
7. A. Maroni, M.D.D. Curto, M. Serratoni, L. Zema, A. Foppoli, A. Gazzaniga, and M.E. Sangalli Feasibility, stability and release performance of a time-dependent insulin delivery system intended for oral colon release Eur. J. Pharm. Biopharm. 72 2009 246 251
8. P.J. Wilson, and A.W. Basit Exploiting gastrointestinal bacteria to target drugs to the colon: an in vitro study using amylose coated tablets Int. J. Pharm. 300 2005 89 94
9. E.L. McConnell, M.D. Short, and A.W. Basit An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man J. Control. Release 130 2008 154 160
10. R. Semde, K. Amighi, D. Pierre, M.J. Devleeschouwer, and A.J. Moes Leachingof pectin from mixed pectin/insoluble polymer films intended for colonic drug delivery Int. J. Pharm. 174 1998 233 241
11. R. Semde, K. Amighi, M.J. Devleeschouwer, and A.J. Moes Studies of pectin HM/Eudragit RL/Eudragit NE film-coating formulations intended for colonicdrug delivery Int. J. Pharm. 197 2000 181 192
12. T. Bautzova, M. Rabiskova, A. Béduneau, Y. Pellequer, and A. Lamprecht Bioadhesive pellets increase 5-aminosalicylic acid concentration in experimental colitis Eur. J. Pharm. Biopharm. 81 2012 379 385
13. V.C. Ibekwe, M.K. Khela, D.F. Evans, and A.W. Basit A new concept in colonic drug targeting: a combined pH-responsive and bacterially-triggered drug delivery technology Aliment. Pharmacol. Ther. 28 2008 911 916
14. E.M. Collnot, H. Ali, and C.M. Lehr Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa J. Control. Release 161 2012 235 246
15. C. Schmidt, C. Lautenschlaeger, E.M. Collnot, M. Schumann, C. Bojarski, J.D. Schulzke, C.M. Lehr, and A. Stallmach Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa - a first in vivo study in human patients J. Control. Release 165 2013 139 145
16. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, L. Dubreuil, P. Desreumaux, and J. Siepmann Colon targeting with bacteria-sensitive films adapted to the disease state Eur. J. Pharm. Biopharm. 73 2009 74 81
17. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, M.P. Flament, L. Dubreuil, P. Desreumaux, and J. Siepmann Novel polymeric film coatings for colon targeting: drug release from coated pellets Eur. J. Pharm. Sci. 37 2009 427 433
18. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, L. Dubreuil, P. Desreumaux, and J. Siepmann Novel polymeric film coatings for colon targeting: how to adjust desired membrane properties Int. J. Pharm. 371 2009 64 70
19. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, P. Desreumaux, and J. Siepmann Characterization of ethylcellulose: starch-based film coatings for colon targeting Drug. Dev. Ind. Pharm. 35 2009 1190 1200
20. Y. Karrout, C. Neut, F. Siepmann, D. Wils, P. Ravaux, L. Deremaux, M.P. Flament, L. Dubreuil, M. Lemdani, P. Desreumaux, and J. Siepmann Enzymatically degraded EC:Eurylon 6 HP-PG film coatings for colon targeting in IBD patients J. Pharm. Pharmacol. 62 2010 1676 1684
21. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, M.P. Flament, L. Dubreuil, P. Desreumaux, and J. Siepmann Enzymatically activated coated multiparticulates containing theophylline for colon targeting J. Drug Del. Sci. Tech. 20 2010 193 199
22. Y. Karrout, C. Neut, D. Wils, F. Siepmann, L. Deremaux, M.P. Flament, L. Dubreuil, P. Desreumaux, and J. Siepmann Peas starch-based film coatings for site-specific drug delivery to the colon J. Appl. Polym. Sci. 119 2011 1176 1184
23. N.G. Kotla, M. Gulati, S.K. Singh, and A. Shivapooja Facts, fallacies and future of dissolution testing of polysaccharide based colon-specific drug delivery J. Control. Release 178 2014 55 62
24. J.L. Wallace, W.K. MacNaughton, G.P. Morris, and P.L. Beck Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease Gastroenterology 96 1989 29 36
25. C.K. Ameho, A.A. Adjei, E.K. Harrison, K. Takeshita, T. Morioka, Y. Arakaki, E. Ito, I. Suzuki, A.D. Kulkarni, A. Kawajiri, and S. Yamamoto Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis Gut 41 1997 487 493
26. D. Rachmilewitz, P.L. Simon, L.W. Schwartz, D.E. Griswold, J.D. Fondacaro, and M.A. Wassermann Inflammatory mediators of experimental colitis in rats Gastroenterology 97 1989 326 337
27. A. Untergrasser, I. Cutcutache, T. Koressaar, J. Ye, B.C. Faircloth, M. Remm, and S.G. Rozen Primer3 - new capabilities and interfaces Nucleic Acids Res. 40 2012 e115
28. T. Koressaar, and M. Remm Enhancements and modifications of primer design program Primer3 Bioinformatics 23 2007 1289 1291
29. N. El-Jamal, L. Dubuquoy, J. Auwerx, B. Bertin, and P. Desreumaux In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice Exp. Dermatol. 22 2013 137 140
30. B. Begue, H. Wajant, J.C. Bambou, L. Dubuquoy, D. Siegmund, J.F. Beaulieu, D. Canioni, D. Berrebi, N. Brousse, P. Desreumaux, J. Schmitz, M.J. Lentze, O. Goulet, N. Cerf-Bensussan, and F.M. Ruemmele Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions Gastroenterology 130 2006 1962 1974
31. L. Dubuquoy, E.A. Jansson, S. Deeb, S. Rakotobe, M. Karoui, J.F. Colombel, J. Auwerx, S. Pettersson, and P. Desreumaux Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis Gastroenterology 124 2003 1265 1276