A novel coating concept for ileo-colonic drug targeting: Proof of concept in humans using scintigraphy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 84, Issue 3, 2013, Pages 573-577

  Varum, F J O ^a   Hatton, G B ^a   Freire, A C ^a   Basit, A W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Biorelevant dissolution; Colonic delivery; Double coating; Gastro resistant coatings; Mesalazine; Modified release

Indexed keywords

BUFFER; EUDRAGIT; MESALAZINE; POLYMER; PREDNISOLONE;

ADULT; ARTICLE; COLON; CONTROLLED STUDY; DOUBLE COATING; DRUG COATING; DRUG RELEASE; DRUG SOLUBILITY; DRUG TARGETING; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; ILEUM; ISOTOPE LABELING; MALE; NORMAL HUMAN; PH; TABLET DISINTEGRATION; TABLET FORMULATION;

ADULT; BICARBONATES; BUFFERS; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; ILEUM; MALE; POLYMETHACRYLIC ACIDS; PREDNISOLONE; RADIONUCLIDE IMAGING; TABLETS; TABLETS, ENTERIC-COATED; TIME FACTORS;

EID: 84879081829     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.01.002     Document Type: Article

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