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Volumn 178, Issue 1, 2014, Pages 55-62

Facts, fallacies and future of dissolution testing of polysaccharide based colon-specific drug delivery

Author keywords

Colon targeting; Dissolution methods; Enzymes; Human faecal slurries; Polysaccharides; Rat caecal contents

Indexed keywords

CONTROLLED DRUG DELIVERY; COST EFFECTIVENESS; DISEASES; DISSOLUTION; ENZYMES; POLYSACCHARIDES; RATS; DIGESTIVE SYSTEM;

EID: 84893480440     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.01.010     Document Type: Article
Times cited : (87)

References (71)
  • 1
    • 0032819165 scopus 로고    scopus 로고
    • Unconventional dissolution methodologies
    • DOI 10.1021/js990139b
    • V. Pillay, and R. Fassihi Unconventional dissolution methodologies J. Pharm. Sci. 88 9 1999 843 851 (Pubitemid 29438947)
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.9 , pp. 843-851
    • Pillay, V.1    Fassihi, R.2
  • 2
    • 45549120102 scopus 로고
    • Theory and practice of site specific drug delivery
    • E. Tomlinson Theory and practice of site specific drug delivery Adv. Drug Deliv. Rev. 1 3 1988 271 272
    • (1988) Adv. Drug Deliv. Rev. , vol.1 , Issue.3 , pp. 271-272
    • Tomlinson, E.1
  • 3
    • 23444440934 scopus 로고    scopus 로고
    • Advances in colon drug delivery
    • A.W. Basit Advances in colon drug delivery Drugs 65 14 2005 1991 2007
    • (2005) Drugs , vol.65 , Issue.14 , pp. 1991-2007
    • Basit, A.W.1
  • 5
    • 0028832474 scopus 로고
    • Approaches and opportunities in colon-specific drug delivery
    • A. Rubinstein Approaches and opportunities in colon-specific drug delivery Crit. Rev. Ther. Drug Carrier Syst. 12 2-3 1995 101 149
    • (1995) Crit. Rev. Ther. Drug Carrier Syst. , vol.12 , Issue.23 , pp. 101-149
    • Rubinstein, A.1
  • 6
    • 0037139415 scopus 로고    scopus 로고
    • Colon-specific drug delivery:New approaches and in vitro/in vivo evaluation
    • L.B. Yang, J.S. Chu, and J.A. Fix Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation Int. J. Pharm. 235 1-2 2002 1 5
    • (2002) Int. J. Pharm. , vol.235 , Issue.12 , pp. 1-5
    • Yang, L.B.1    Chu, J.S.2    Fix, J.A.3
  • 7
    • 0032473475 scopus 로고    scopus 로고
    • Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers
    • DOI 10.1016/S0168-3659(97)00201-0, PII S0168365997002010
    • M. Muraoka, Z. Hu, T. Shimokawa, S. Sekino, R. Kurogoshi, Y. Kuboi, Y. Yoshikawa, and K. Takada Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers J. Control. Release 52 1-2 1998 119 129 (Pubitemid 28123179)
    • (1998) Journal of Controlled Release , vol.52 , Issue.1-2 , pp. 119-129
    • Muraoka, M.1    Hu, Z.2    Shimokawa, T.3    Sekino, S.-I.4    Kurogoshi, R.-E.5    Kuboi, Y.6    Yoshikawa, Y.7    Takada, K.8
  • 8
    • 43249131235 scopus 로고    scopus 로고
    • Asymmetric membrane in membrane capsules: A means for achieving delayed and osmotic flow of cefadroxil
    • A.K. Philip, K. Pathak, and P. Shakya Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil Eur. J. Pharm. Biopharm. 69 2 2008 658 666
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.2 , pp. 658-666
    • Philip, A.K.1    Pathak, K.2    Shakya, P.3
  • 9
    • 46749083350 scopus 로고    scopus 로고
    • Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems
    • V.C. Ibekwe, H.M. Fadda, E.L. McConnell, M.K. Khela, D.F. Evans, and A.W. Basit Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems Pharm. Res. 25 8 2008 1828 1835
    • (2008) Pharm. Res. , vol.25 , Issue.8 , pp. 1828-1835
    • Ibekwe, V.C.1    Fadda, H.M.2    Mcconnell, E.L.3    Khela, M.K.4    Evans, D.F.5    Basit, A.W.6
  • 10
    • 0030906756 scopus 로고    scopus 로고
    • USP dissolution apparatus III (reciprocating cylinder) for screening of guar-based colonic delivery formulations
    • DOI 10.1016/S0168-3659(97)01633-7, PII S0168365997016337
    • D. Wong, S. Larrabee, K. Clifford, J. Tremblay, and D.R. Friend USP dissolution apparatus III (reciprocating cylinder) for screening of guar based colonic delivery formulations J. Control. Release 47 1997 173 179 (Pubitemid 27212344)
    • (1997) Journal of Controlled Release , vol.47 , Issue.2 , pp. 173-179
    • Wong, D.1    Larrabee, S.2    Clifford, K.3    Tremblay, J.4    Friend, D.R.5
  • 11
    • 0141800053 scopus 로고    scopus 로고
    • FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms
    • M. Siewert, J. Dressman, C.K. Brown, and V.P. Shah FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms AAPS PharmSciTech 4 1 2003 43 52
    • (2003) AAPS PharmSciTech , vol.4 , Issue.1 , pp. 43-52
    • Siewert, M.1    Dressman, J.2    Brown, C.K.3    Shah, V.P.4
  • 12
    • 34249745232 scopus 로고    scopus 로고
    • In vitro evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin
    • DOI 10.1080/10611860601143727, PII 771044348
    • C. Ji, H. Xu, and W. Wu In vitro evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin J. Drug Target. 15 2 2007 123 131 (Pubitemid 46957698)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.2 , pp. 123-131
    • Ji, C.1    Xu, H.2    Wu, W.3
  • 13
    • 2942665780 scopus 로고    scopus 로고
    • Degradation of raw or film-incorporated β-cyclodextrin by enzymes and colonic bacteria
    • DOI 10.1016/j.ejpb.2004.02.001, PII S0939641104000323
    • A. Fetzner, S. Böhm, S. Schreder, and R. Schubert Degradation of raw or film incorporated β-cyclodextrin by enzymes and colonic bacteria Eur. J. Pharm. Biopharm. 58 1 2004 91 97 (Pubitemid 38781009)
    • (2004) European Journal of Pharmaceutics and Biopharmaceutics , vol.58 , Issue.1 , pp. 91-97
    • Fetzner, A.1    Bohm, S.2    Schreder, S.3    Schubert, R.4
  • 14
    • 34248634005 scopus 로고    scopus 로고
    • Photocrosslinking of dextran and polyaspartamide derivatives: A combination suitable for colon-specific drug delivery
    • DOI 10.1016/j.jconrel.2007.03.005, PII S0168365907001307
    • G. Pitarresi, M.A. Casadei, D. Mandracchia, P. Paolicelli, F.S. Palumbo, and G. Giammona Photo crosslinking of dextran and polyaspartamide derivatives: a combination suitable for colon-specific drug delivery J. Control. Release 119 3 2007 328 338 (Pubitemid 46770878)
    • (2007) Journal of Controlled Release , vol.119 , Issue.3 , pp. 328-338
    • Pitarresi, G.1    Casadei, M.A.2    Mandracchia, D.3    Paolicelli, P.4    Palumbo, F.S.5    Giammona, G.6
  • 15
    • 34250854656 scopus 로고    scopus 로고
    • Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture
    • DOI 10.1016/j.ejpb.2007.01.016, PII S0939641107000185
    • T. Ugurlu, M. Turkoglu, U.S. Gurer, and B.G. Akarsu Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture Eur. J. Pharm. Biopharm. 67 1 2007 202 210 (Pubitemid 46991338)
    • (2007) European Journal of Pharmaceutics and Biopharmaceutics , vol.67 , Issue.1 , pp. 202-210
    • Ugurlu, T.1    Turkoglu, M.2    Gurer, U.S.3    Akarsu, B.G.4
  • 16
    • 0027476168 scopus 로고
    • In vitro evaluation of calcium pectinate: A potential colon-specific drug delivery carrier
    • DOI 10.1023/A:1018995029167
    • A. Rubinstein, R. Radai, M. Ezra, S. Pathak, and J.S. Rokem In vitro evaluation of calcium pectinate: a potential colon-specific drug delivery carrier Pharm. Res. 10 2 1993 258 263 (Pubitemid 23041741)
    • (1993) Pharmaceutical Research , vol.10 , Issue.2 , pp. 258-263
    • Rubinstein, A.1    Radai, R.2    Ezra, M.3    Pathak, S.4    Rokem, J.S.5
  • 17
    • 0024117598 scopus 로고
    • Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria
    • G.R. Gibson, J.H. Cummings, and G.T. Macfarlane Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria Appl. Environ. Microbiol. 54 11 1988 2750 2755
    • (1988) Appl. Environ. Microbiol. , vol.54 , Issue.11 , pp. 2750-2755
    • Gibson, G.R.1    Cummings, J.H.2    Macfarlane, G.T.3
  • 18
    • 0024445045 scopus 로고
    • Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system
    • G.T. Macfarlane, J.H. Cummings, S. Macfarlane, and G.R. Gibson Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system J. Appl. Bacteriol. 76 5 1989 520 527
    • (1989) J. Appl. Bacteriol. , vol.76 , Issue.5 , pp. 520-527
    • Macfarlane, G.T.1    Cummings, J.H.2    Macfarlane, S.3    Gibson, G.R.4
  • 19
    • 1542328825 scopus 로고    scopus 로고
    • Amylose formulations for drug delivery to the colon: A comparison of two fermentation models to assess colonic targeting performance in vitro
    • DOI 10.1016/j.ijpharm.2003.12.015, PII S037851730300704X
    • L.F. Siew, S.M. Man, J.M. Newton, and A.W. Basit Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro Int. J. Pharm. 273 1-2 2004 129 134 (Pubitemid 38317047)
    • (2004) International Journal of Pharmaceutics , vol.273 , Issue.1-2 , pp. 129-134
    • Siew, L.F.1    Man, S.-M.2    Newton, J.M.3    Basit, A.W.4
  • 20
    • 75149114692 scopus 로고    scopus 로고
    • Influence of the coating formulation on enzymatic digestibility and drug release from 5-aminosalicylic acid pellets coated with mixtures of high-amylose starch and Surelease intended for colon-specific drug delivery
    • C. Freire, F. Podczeck, F. Veiga, and J. Sousa Influence of the coating formulation on enzymatic digestibility and drug release from 5-aminosalicylic acid pellets coated with mixtures of high-amylose starch and Surelease intended for colon-specific drug delivery Drug Dev. Ind. Pharm. 36 2 2010 161 172
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , Issue.2 , pp. 161-172
    • Freire, C.1    Podczeck, F.2    Veiga, F.3    Sousa, J.4
  • 22
    • 43249130204 scopus 로고    scopus 로고
    • Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery
    • F. Maestrelli, M. Cirri, G. Corti, N. Mennini, and M. Paola Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery Eur. J. Pharm. Biopharm. 69 2 2008 508 518
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.2 , pp. 508-518
    • Maestrelli, F.1    Cirri, M.2    Corti, G.3    Mennini, N.4    Paola, M.5
  • 23
    • 84874407282 scopus 로고    scopus 로고
    • Preparation and evaluation of pectin based colon-specific pulsatile capsule in vitro and in vivo
    • J. Liu, L. Zhang, Y. Jia, W. Hu, J. Zhang, and H. Jiang Preparation and evaluation of pectin based colon-specific pulsatile capsule in vitro and in vivo Arch. Pharm. Res. 35 11 2012 1927 1934
    • (2012) Arch. Pharm. Res. , vol.35 , Issue.11 , pp. 1927-1934
    • Liu, J.1    Zhang, L.2    Jia, Y.3    Hu, W.4    Zhang, J.5    Jiang, H.6
  • 24
    • 0034002448 scopus 로고    scopus 로고
    • Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate
    • DOI 10.1016/S0378-5173(99)00465-2, PII S0378517399004652
    • R. Semde, K. Amighi, M.J. Devleeschouwer, and A.J. Moes Effect of pectinolytic enzymes on theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate Int. J. Pharm. 197 1-2 2000 169 179 (Pubitemid 30125788)
    • (2000) International Journal of Pharmaceutics , vol.197 , Issue.1-2 , pp. 169-179
    • Semde, R.1    Amighi, K.2    Devleeschouwer, M.J.3    Moes, A.J.4
  • 25
    • 0033998408 scopus 로고    scopus 로고
    • Studies of pectin HM/Eudragit® RL/Eudragit® NE film-coating formulations intended for colonic drug delivery
    • DOI 10.1016/S0378-5173(99)00467-6, PII S0378517399004676
    • R. Semde, K. Amighi, M.J. Devleeschouwer, and A.J. Moës Studies of pectin HM/Eudragit NE film-coating formulations intended for colonic drug delivery Int. J. Pharm. 197 1-2 2000 181 192 (Pubitemid 30125789)
    • (2000) International Journal of Pharmaceutics , vol.197 , Issue.1-2 , pp. 181-192
    • Semde, R.1    Amighi, K.2    Devleeschouwer, M.J.3    Moes, A.J.4
  • 26
    • 36749064579 scopus 로고    scopus 로고
    • Colon-specific drug delivery for mebeverine hydrochloride
    • DOI 10.1080/10611860701603281, PII 787298179
    • S. Omar, B. Aldosar, H. Refai, and O.A. Gohary Colon-specific drug delivery for mebeverine hydrochloride J. Drug Target. 15 10 2007 691 700 (Pubitemid 350201322)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.10 , pp. 691-700
    • Omar, S.1    Aldosari, B.2    Refai, H.3    Al Gohary, O.4
  • 27
    • 34247885738 scopus 로고    scopus 로고
    • Design and development of hydrogel beads for targeted drug delivery to the colon
    • S.K. Jain, A. Jain, Y. Gupta, and M. Ahirwar Design and development of hydrogel beads for targeted drug delivery to the colon AAPSPharmSciTech 8 3 2007 E34 E41
    • (2007) AAPSPharmSciTech , vol.8 , Issue.3
    • Jain, S.K.1    Jain, A.2    Gupta, Y.3    Ahirwar, M.4
  • 28
    • 74949127656 scopus 로고    scopus 로고
    • Development of pH and enzyme controlled, colon targeted, pulsed delivery system of poorly water-soluble drug: Preparation and in vitro evaluation
    • H. Lai, K. Lin, W. Zhang, Z. Zhang, L. Jie, Y. Wu, and Q. He Development of pH and enzyme controlled, colon targeted, pulsed delivery system of poorly water-soluble drug: preparation and in vitro evaluation Drug Dev. Ind. Pharm. 36 1 2010 81 92
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , Issue.1 , pp. 81-92
    • Lai, H.1    Lin, K.2    Zhang, W.3    Zhang, Z.4    Jie, L.5    Wu, Y.6    He, Q.7
  • 32
    • 0015156082 scopus 로고
    • Intestinal bacteria and the hydrolysis of glycosidic bonds
    • G.B. Hawksworth, S. Drasar, and M.J. Hill Intestinal bacteria and the hydrolysis of glycosidic bonds J. Med. Microbiol. 4 4 1971 451 459
    • (1971) J. Med. Microbiol. , vol.4 , Issue.4 , pp. 451-459
    • Hawksworth, G.B.1    Drasar, S.2    Hill, M.J.3
  • 33
    • 79960002411 scopus 로고    scopus 로고
    • Preparation and characterization of satranidazole loaded calcium pectinate microbeads for colon specific delivery; application of response surface methodology
    • A.R. Tiwari, S. Ramteke, R. Dahima, and R. Shukla Preparation and characterization of satranidazole loaded calcium pectinate microbeads for colon specific delivery; application of response surface methodology Curr. Nanosci. 7 8 2011 608 615
    • (2011) Curr. Nanosci. , vol.7 , Issue.8 , pp. 608-615
    • Tiwari, A.R.1    Ramteke, S.2    Dahima, R.3    Shukla, R.4
  • 34
    • 84863886669 scopus 로고    scopus 로고
    • Enteric coated guar gum microspheres of ornidazole for colonic drug delivery
    • R.K. Shukla, R. Suman, P. Trivedi, and A. Tiwari Enteric coated guar gum microspheres of ornidazole for colonic drug delivery Curr. Nanosci. 8 4 2012 571 580
    • (2012) Curr. Nanosci. , vol.8 , Issue.4 , pp. 571-580
    • Shukla, R.K.1    Suman, R.2    Trivedi, P.3    Tiwari, A.4
  • 36
    • 0035068443 scopus 로고    scopus 로고
    • Comparative gastrointestinal and plasma cholesterol responses of rats fed on cholesterol-free diets supplemented with guar gum and sodium alginate
    • C.J. Seal, and J.C. Mathers Comparative gastrointestinal and plasma cholesterol responses of rats fed on cholesterol-free diets supplemented with guar gum and sodium alginate Br. J. Nutr. 85 3 2001 317 324 (Pubitemid 32293760)
    • (2001) British Journal of Nutrition , vol.85 , Issue.3 , pp. 317-324
    • Seal, C.J.1    Mathers, J.C.2
  • 37
    • 2342549282 scopus 로고    scopus 로고
    • Physiological effects of lactulose and inulin in the caecum of rats
    • DOI 10.1080/00039420310001656703
    • Z. Zduńczyk, J. Juśkiewicz, M. Wróblewska, and B. Król Physiological effects of lactulose and inulin in the caecum of rats Arch. Anim. Nutr. 58 1 2004 89 98 (Pubitemid 38597307)
    • (2004) Archives of Animal Nutrition , vol.58 , Issue.1 , pp. 89-98
    • Zdunczyk, Z.1    Juskiewicz, J.2    Wroblewska, M.3    Krol, B.4
  • 38
    • 0032509914 scopus 로고    scopus 로고
    • In vitro evaluation of guar gum as a carder for colon-specific drug delivery
    • DOI 10.1016/S0168-3659(97)00181-8, PII S0168365997001818
    • Y.V. Prasad, Y.S. Krishnaiah, and V. Satyanarayana In vitro evaluation of guar gum as a carrier for colon-specific drug delivery J. Control. Release 51 2-3 1998 281 287 (Pubitemid 28252880)
    • (1998) Journal of Controlled Release , vol.51 , Issue.2-3 , pp. 281-287
    • Prasad, Y.V.R.1    Krishnaiah, Y.S.R.2    Satyanarayana, S.3
  • 39
    • 34447549176 scopus 로고    scopus 로고
    • Potential of calcium pectinate beads for target specific drug release to colon
    • DOI 10.1080/10611860601146134, PII 778356582
    • A. Jain, Y. Gupta, and S.K. Jain Potential of calcium pectinate beads for target specific drug release to colon J. Drug Target. 15 4 2007 285 294 (Pubitemid 47177036)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.4 , pp. 285-294
    • Jain, A.1    Gupta, Y.2    Jain, S.K.3
  • 41
    • 78650259706 scopus 로고    scopus 로고
    • Effect of 5-fluorouracil pretreatment on the in vitro drug release from colon targeted guar gum matrix tablets
    • Y.S. Krishnaiah, and B.P. Srinivas Effect of 5-fluorouracil pretreatment on the in vitro drug release from colon targeted guar gum matrix tablets Open Drug Deliv. J. 2 1 2008 71 76
    • (2008) Open Drug Deliv. J. , vol.2 , Issue.1 , pp. 71-76
    • Krishnaiah, Y.S.1    Srinivas, B.P.2
  • 43
    • 34247873146 scopus 로고    scopus 로고
    • Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon
    • A. Jain, Y. Gupta, and S.K. Jain Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon J. Pharm. Sci. 10 1 2007 86 128 (Pubitemid 46692379)
    • (2007) Journal of Pharmacy and Pharmaceutical Sciences , vol.10 , Issue.1 , pp. 86-128
    • Jain, A.1    Gupta, Y.2    Jain, S.K.3
  • 44
    • 34247469281 scopus 로고    scopus 로고
    • Pectin/ethylcellulose as film coatings for colon-specific drug delivery: Preparation and in vitro evaluation using 5-fluorouracil pellets
    • H. Wei, D. Qing, C. De-Ying, X. Bai, and F. Li-Fang Pectin/ethyl cellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets PDA J. Pharm. Sci. Technol. 61 2 2007 121 130 (Pubitemid 46651444)
    • (2007) PDA Journal of Pharmaceutical Science and Technology , vol.61 , Issue.2 , pp. 121-130
    • Wei, H.1    Qing, D.2    De-Ying, C.3    Bai, X.4    Fanli-Fang5
  • 45
    • 38349086771 scopus 로고    scopus 로고
    • In vitro and in vivo studies of pectin/ethyl cellulose film-coated pellets of 5-fluorouracil for colon targeting
    • H. Wei, D. Qing, C. De-Ying, X. Bai, and F. Li-Fang In vitro and in vivo studies of pectin/ethyl cellulose film-coated pellets of 5-fluorouracil for colon targeting J. Pharm. Pharmacol. 60 1 2008 35 44
    • (2008) J. Pharm. Pharmacol. , vol.60 , Issue.1 , pp. 35-44
    • Wei, H.1    Qing, D.2    De-Ying, C.3    Bai, X.4    Li-Fang, F.5
  • 47
    • 79952048160 scopus 로고    scopus 로고
    • Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat
    • J. Varshosaz, F. Ahmadi, J. Emami, N. Tavakoli, and M. Minaiyan Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat Int. J. Prev. Med. 1 2 2010 115 123
    • (2010) Int. J. Prev. Med. , vol.1 , Issue.2 , pp. 115-123
    • Varshosaz, J.1    Ahmadi, F.2    Emami, J.3    Tavakoli, N.4    Minaiyan, M.5
  • 48
    • 0027651394 scopus 로고
    • Factors affecting fermentation reactions in the large bowel
    • G.T. Macfarlane, and S. Macfarlane Factors affecting fermentation reactions in the large bowel Proc. Nutr. Soc. 52 2 1993 367 373
    • (1993) Proc. Nutr. Soc. , vol.52 , Issue.2 , pp. 367-373
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 49
    • 79958138880 scopus 로고    scopus 로고
    • Development of novel budesonide pellets based on CODES™ technology: in vitro/in vivo evaluation in induced colitis in rats
    • J. Varshosaz, J. Emami, N. Tavakoli, M. Minaiyan, N. Rahmani, F. Dorkoosh, and P. Mahzouni Development of novel budesonide pellets based on CODES™ technology: in vitro/in vivo evaluation in induced colitis in rats Daru 19 2 2011 107 117
    • (2011) Daru , vol.19 , Issue.2 , pp. 107-117
    • Varshosaz, J.1    Emami, J.2    Tavakoli, N.3    Minaiyan, M.4    Rahmani, N.5    Dorkoosh, F.6    Mahzouni, P.7
  • 50
    • 41049101803 scopus 로고    scopus 로고
    • Influence of natural polymer coating on novel colon targeting drug delivery system
    • V. Ravi, T.M. Siddaramallah, and P. Kumar Influence of natural polymer coating on novel colon targeting drug delivery system J. Mater. Sci. Mater. Med. 19 5 2008 2131 2136
    • (2008) J. Mater. Sci. Mater. Med. , vol.19 , Issue.5 , pp. 2131-2136
    • Ravi, V.1    Siddaramallah, T.M.2    Kumar, P.3
  • 51
    • 79551505094 scopus 로고    scopus 로고
    • Preparation and characterization of cross-linked guar gum microspheres: Optimization using factorial design
    • R.K. Shukla, P. Trivedi, S. Ramteke, and A. Tiwari Preparation and characterization of cross-linked guar gum microspheres: optimization using factorial design Chem. Pharm. Bull. (Tokyo) 59 2 2011 185 190
    • (2011) Chem. Pharm. Bull. (Tokyo) , vol.59 , Issue.2 , pp. 185-190
    • Shukla, R.K.1    Trivedi, P.2    Ramteke, S.3    Tiwari, A.4
  • 52
    • 34247469281 scopus 로고    scopus 로고
    • Pectin/ethylcellulose as film coatings for colon-specific drug delivery: Preparation and in vitro evaluation using 5-fluorouracil pellets
    • H. Wei, D. Quing, C. De-Ying, X. Bai, and F. Fang Pectin/ethylcellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets, PDA J. Pharm. Sci. Technol. 61 2 2007 121 130 (Pubitemid 46651444)
    • (2007) PDA Journal of Pharmaceutical Science and Technology , vol.61 , Issue.2 , pp. 121-130
    • Wei, H.1    Qing, D.2    De-Ying, C.3    Bai, X.4    Fanli-Fang5
  • 53
    • 0035997045 scopus 로고    scopus 로고
    • In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil
    • DOI 10.1016/S0928-0987(02)00081-7, PII S0928098702000817
    • Y.S. Krishnaiah, V. Satyanarayana, B. Dinesh Kumar, and R.S. Karthikeyan In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil Eur. J. Pharm. Sci. 16 3 2002 185 192 (Pubitemid 34786453)
    • (2002) European Journal of Pharmaceutical Sciences , vol.16 , Issue.3 , pp. 185-192
    • Krishnaiah, Y.S.R.1    Satyanarayana, V.2    Dinesh Kumar, B.3    Karthikeyan, R.S.4
  • 54
    • 79955111843 scopus 로고    scopus 로고
    • Colon targeted quercetin delivery using natural polymer to enhance its bioavailability
    • A. Singhal, H. Jain, V. Singhal, E.J. Elias, and A. Showkat Colon targeted quercetin delivery using natural polymer to enhance its bioavailability Pharmacogn. Res 3 1 2011 35 39
    • (2011) Pharmacogn. Res , vol.3 , Issue.1 , pp. 35-39
    • Singhal, A.1    Jain, H.2    Singhal, V.3    Elias, E.J.4    Showkat, A.5
  • 55
    • 27644582026 scopus 로고    scopus 로고
    • Development of colon-targeted albendazole-β-cyclodextrin-complex drug delivery systems
    • DOI 10.1002/ddr.20010
    • S. Shyale, K.P.R. Chowdhary, and Y.S. Krishnaiah Development of colon-targeted albendazole-β-cyclodextrin-complex drug delivery system Drug Dev. Res. 65 2 2005 76 83 (Pubitemid 41566366)
    • (2005) Drug Development Research , vol.65 , Issue.2 , pp. 76-83
    • Shyale, S.1    Chowdhary, K.P.R.2    Krishnaiah, Y.S.R.3
  • 56
    • 0027651394 scopus 로고
    • Factors affecting fermentation reactions in the large bowel
    • G.T. Macfarlane, and S. Macfarlane Factors affecting fermentation reactions in the large bowel Proc. Nutr. Soc. 52 2 1993 367 373
    • (1993) Proc. Nutr. Soc. , vol.52 , Issue.2 , pp. 367-373
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 57
    • 0018170315 scopus 로고
    • Some current concepts in intestinal bacteriology
    • W.E. Moore, E.P. Cato, and L.V. Holdeman Some current concepts in intestinal bacteriology Am. J. Clin. Nutr. 31 10 Suppl. 1978 S33 S42
    • (1978) Am. J. Clin. Nutr. , vol.31 , Issue.10 SUPPL.
    • Moore, W.E.1    Cato, E.P.2    Holdeman, L.V.3
  • 58
    • 0018828394 scopus 로고
    • Mechanism of action of dietary fibre in the human colon
    • A.M. Stephen, and J.H. Cummings Mechanism of action of dietary fibre in the human colon Nature 284 5753 1980 283 284 (Pubitemid 10112057)
    • (1980) Nature , vol.284 , Issue.5753 , pp. 283-284
    • Stephen, A.M.1    Cummings, J.H.2
  • 59
  • 61
    • 2042548624 scopus 로고    scopus 로고
    • The potential of organic-based amylase-ethyl cellulose film coatings as oral colo-specific drug delivery systems
    • L.F. Siew, A.W. Basit, and J.M. Newton The potential of organic-based amylase-ethyl cellulose film coatings as oral colo-specific drug delivery systems AAPS PharmSciTech 1 3 2000 53 61
    • (2000) AAPS PharmSciTech , vol.1 , Issue.3 , pp. 53-61
    • Siew, L.F.1    Basit, A.W.2    Newton, J.M.3
  • 62
    • 33947647965 scopus 로고    scopus 로고
    • Colonic drug delivery using amylose films: The role of aqueous ethylcellulose dispersions in controlling drug release
    • DOI 10.1007/s10570-006-9078-8, Polysaccharides in Drug Delivery
    • E.L. McConnel, J. Tutas, M.A.M. Mohammad, D. Banning, and A.W. Basit Colonic drug delivery using amylase films: the role of aqueous ethyl cellulose dispersions in controlling drug release Cellulose 14 1 2007 25 34 (Pubitemid 46486878)
    • (2007) Cellulose , vol.14 , Issue.1 , pp. 25-34
    • McConnell, E.L.1    Tutas, J.2    Mohamed, M.A.M.3    Banning, D.4    Basit, A.W.5
  • 63
    • 41649086622 scopus 로고    scopus 로고
    • Formulation and in-vitro evaluation of dextrin matrix tablet of ibuprofen for colon specific drug delivery
    • K.S. Salunkhe, and M.V. Kulkarni Formulation and in-vitro evaluation of dextrin matrix tablet of ibuprofen for colon specific drug delivery Pak. J. Pharm. Sci. 21 1 2008 17 20
    • (2008) Pak. J. Pharm. Sci. , vol.21 , Issue.1 , pp. 17-20
    • Salunkhe, K.S.1    Kulkarni, M.V.2
  • 66
    • 0027251567 scopus 로고
    • Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem
    • K. Molly, M.V. Woestyne, and W. Verstraete Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem Appl. Microbiol. Biotechnol. 39 2 1993 254 258 (Pubitemid 23134616)
    • (1993) Applied Microbiology and Biotechnology , vol.39 , Issue.2 , pp. 254-258
    • Molly, K.1    Vande Woestyne, M.2    Verstraete, W.3
  • 67
    • 0031827171 scopus 로고    scopus 로고
    • Polysaccharide degradation by human intestinal bacteria during growth under multi-substrate limiting conditions in a three-stage continuous culture system
    • DOI 10.1016/S0168-6496(98)00039-7, PII S0168649698000397
    • S. Macfarlane, M.E. Quigley, M.J. Hopkins, D.F. Newton, and G.T. Macfarlane Polysaccharide degradation by human intestinal bacteria during growth under multi-substrate limiting conditions in a three-stage continuous culture system FEMS Microbiol. Ecol. 26 3 1998 231 243 (Pubitemid 28319956)
    • (1998) FEMS Microbiology Ecology , vol.26 , Issue.3 , pp. 231-243
    • Macfarlane, S.1    Quigley, M.E.2    Hopkins, M.J.3    Newton, D.F.4    Macfarlane, G.T.5
  • 69
    • 37349028271 scopus 로고    scopus 로고
    • Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora
    • DOI 10.1016/j.jconrel.2007.10.026, PII S0168365907006219
    • L. Yang Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora J. Control. Release 125 2 2008 77 86 (Pubitemid 350299614)
    • (2008) Journal of Controlled Release , vol.125 , Issue.2 , pp. 77-86
    • Yang, L.1
  • 70
    • 33947647965 scopus 로고    scopus 로고
    • Colonic drug delivery using amylose films: The role of aqueous ethylcellulose dispersions in controlling drug release
    • DOI 10.1007/s10570-006-9078-8, Polysaccharides in Drug Delivery
    • E.L.J. McConnell, M.A.M. Tutas, M. Mohamed, D. Banning, and Abdul Basit Colonic drug delivery using amylose films: the role of aqueous ethyl cellulose dispersions in controlling drug release Cellulose 14 1 2007 25 34 (Pubitemid 46486878)
    • (2007) Cellulose , vol.14 , Issue.1 , pp. 25-34
    • McConnell, E.L.1    Tutas, J.2    Mohamed, M.A.M.3    Banning, D.4    Basit, A.W.5


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