Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice

Toxicological Sciences

Volumn 141, Issue 2, 2014, Pages 515-523

  Kopec, Anna K ^a   Sullivan, Bradley P ^b   Kassel, Karen M ^b   Joshi, Nikita ^c   Luyendyk, James P ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Autoimmunity; Cholangitis; Liver; Mouse; Trichloroethylene

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BETA6 INTEGRIN; COLLAGEN TYPE 1; EARLY GROWTH RESPONSE FACTOR 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA2; TRICHLOROETHYLENE; COLLAGEN TYPE I, ALPHA 1 CHAIN; EGR1 PROTEIN, MOUSE; MESSENGER RNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE LIVER DISEASE; AUTOIMMUNE MEDIATED CHOLANGITIS; BILE DUCT CYST; CD3+ T LYMPHOCYTE; CHOLANGITIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FIBROGENESIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOMICS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOXICOGENETICS; TOXICOGENOMIC ANALYSIS; ANIMAL; AUTOIMMUNE DISEASE; DISEASE MODEL; DNA MICROARRAY; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LIVER; LIVER CIRRHOSIS, BILIARY; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROCEDURES;

MUS;

ANIMALS; AUTOIMMUNE DISEASES; CHOLANGITIS; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE-ENVIRONMENT INTERACTION; LIVER; LIVER CIRRHOSIS, BILIARY; MICE, INBRED NOD; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; TOXICOGENETICS; TRICHLOROETHYLENE;

EID: 84911463778     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu148     Document Type: Article

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