Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R

Acta Biochimica et Biophysica Sinica

Volumn 46, Issue 11, 2014, Pages 965-972

  Xu, Honghai ^a   Liu, Cong ^b   Zhang, Yuelin ^a   Guo, Xiong ^c   Liu, Zongzhi ^a   Luo, Zhenqun ^a   Chang, Yanhai ^a   Liu, Shizhang ^a   Sun, Zhengming ^a   Wang, Xiaoqing ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Let 7b 5p; Multiple myeloma; Proliferation

Indexed keywords

3' UNTRANSLATED REGION; IGF1R PROTEIN, HUMAN; MESSENGER RNA; MICRORNA; MIRNLET7 MICRORNA, HUMAN; RNA; SOMATOMEDIN RECEPTOR;

3' UNTRANSLATED REGION; ADULT; AGED; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CASE CONTROL STUDY; CELL PROLIFERATION; DOWN REGULATION; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; MULTIPLE MYELOMA; PATHOLOGY; TUMOR CELL LINE; VERY ELDERLY;

3' UNTRANSLATED REGIONS; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; MICRORNAS; MIDDLE AGED; MULTIPLE MYELOMA; RECEPTORS, SOMATOMEDIN; RNA, MESSENGER; RNA, NEOPLASM;

EID: 84911458551     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmu089     Document Type: Article

References (31)

1. Barlogie B, Jagannath S, Epstein J, Munshi N, Siegel D, Desikan K and Feinman R, et al. Biology and therapy of multiple myeloma in 1996. Semin Hematoled 1997, 34: 67-72.
2. Kuehl WM and Bergsagel PL. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2002, 2: 175-187.
3. Hajek R, Krejci M, Pour L and Adam Z. Multiple myeloma. Klin Onkol 2011, 24: S10-S13.
4. Palumbo A and Anderson K. Multiple myeloma. N Engl J Med 2011, 364: 1046-1060.
5. Tagliaferri P, Rossi M, Di Martino M, Amodio N, Leone E, Gulla A and Neri A, et al. Promises and challenges of MicroRNA-based treatment of multiple myeloma. Curr Drug Targets 2012, 12: 838.
6. Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E and Botta C, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 2013, 228: 1506-1515.
7. Pichiorri F, Suh S-S, Ladetto M, Kuehl M, Palumbo T, Drandi D and Taccioli C, et al. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA 2008, 105: 12885-12890.
8. Lionetti M, Biasiolo M, Agnelli L, Todoerti K, Mosca L, Fabris S and Sales G, et al. Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma. Blood 2009, 114: e20-e26.
9. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S and Shimizu M, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004, 101: 2999-3004.
10. le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A and Anile C, et al. Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 2007, 26: 3699-3708.
11. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M and Wojcik SE, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005, 102: 13944-13949.
12. Fu X, Meng Z, Liang W, Tian Y, Wang X, Han W and Lou G, et al. miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Oncogene 2014, 33: 4296-4306.
13. Schmittgen TD and Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc 2008, 3: 1101-1108.
14. Ye F, Tang H, Liu Q, Xie X, Wu M, Liu X and Chen B, et al. miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family. J Transl Med 2014, 12: 17.
15. Li P, Xu Q, Zhang D, Li X, Han L, Lei J and Duan W, et al. Upregulated miR-106a plays an oncogenic role in pancreatic cancer. FEBS Lett 2014, 588: 705-712.
16. Amodio N, Bellizzi D, Leotta M, Raimondi L, Biamonte L, DAquila P and Di Martino MT, et al. miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells. Cell Cycle 2013, 12: 3650-3662.
17. Schultz J, Lorenz P, Gross G, Ibrahim S and Kunz M. MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res 2008, 18: 549-557.
18. Lee YS and Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 2007, 21: 1025-1030.
19. Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K and Mori M. Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res 2008, 14: 2334-2340.
20. Ma L, Li G, Wu Z and Meng G. Prognostic significance of let-7b expression in breast cancer and correlation to its target gene of BSG expression. Med Oncol 2014, 31: 1-5.
21. Chen F, Chen C, Yang S, Gong W, Wang Y, Cianflone K and Tang J, et al. Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2. PLoS One 2012, 7: e39197.
22. Guo Y, Yan K, Fang J, Qu Q, Zhou M and Chen F. Let-7b expression determines response to chemotherapy through the regulation of cyclin D1 in glioblastoma. J Exp Clin Cancer Res 2013, 32: 1-10.
23. Chitnis MM, Yuen JS, Protheroe AS, Pollak M and Macaulay VM. The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res 2008, 14: 6364-6370.
24. Valentinis B and Baserga R. IGF-I receptor signaling in transformation and differentiation. Mol Pathol 2001, 54: 133-137.
25. Gately K, Forde L, Cuffe S, Cummins R, Kay EW, Feuerhake F and OByrne KJ. High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non-small-cell lung cancer. Clin Lung Cancer 2013, 15: 58-66.
26. Li ZJ, Ying XJ, Chen HL, Ye PJ, Chen ZL, Li G and Jiang HF, et al. Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer.World J Gastroenterol 2013, 19: 7788-7794.
27. Sayeed A, Fedele C, Trerotola M, Ganguly KK and Languino LR. IGF-IR promotes prostate cancer growth by stabilizing alpha5beta1 integrin protein levels. PLoS One 2013, 8: e76513.
28. Dai G, Peng T, Zhou X, Zhu J, Kong Z, Ma L and Xiong Z, et al. Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes. Biochem Biophys Res Commun 2013, 440: 479-484.
29. Yuan Y, Shen Y, Xue L and Fan H. miR-140 suppresses tumor growth and metastasis of non-small cell lung cancer by targeting insulin-like growth factor 1 receptor. PLoS One 2013, 8: e73604.
30. Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ES, Liu L and Luo Z, et al. Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer. Proc Natl Acad Sci USA 2013, 110: 15043-15048.
31. Farhana L, Dawson MI, Murshed F, Das JK, Rishi AK and Fontana JA. Upregulation of miR-150∗ and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. PLoS One 2013, 8: e61015.