High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non-small-cell lung cancer

Clinical Lung Cancer

Volumn 15, Issue 1, 2014, Pages 58-66

  Gately, Kathy ^a   Forde, Lydia ^a   Cuffe, Sinead ^a   Cummins, Robert ^b   Kay, Elaine W ^b   Feuerhake, Friedrich ^c   O'Byrne, Kenneth J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

EGFR; IGF1R; NSCLC; Prognostic marker

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OVERALL SURVIVAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; VERY ELDERLY; WESTERN BLOTTING;

EGFR; IGF1R; NSCLC; PROGNOSTIC MARKER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, IGF TYPE 1; RETROSPECTIVE STUDIES; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84891834273     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2013.08.005     Document Type: Article

References (42)

1. A. Ullrich, and J. Schlessinger Signal transduction by receptors with tyrosine kinase activity Cell 61 1990 203 212
2. D. Veale, T. Ashcroft, and C. Marsh et al. Epidermal growth factor receptors in non-small cell lung cancer Br J Cancer 55 1987 513 516
3. U. Pastorino, S. Andreola, and E. Tagliabue et al. Immunocytochemical markers in stage I lung cancer: relevance to prognosis J Clin Oncol 15 1997 2858 2865
4. M. Volm, P. Drings, and W. Wodrich Prognostic significance of the expression of c-fos, c-jun and c-erbB1 oncogene products in human squamous cell lung carcinomas J Cancer Res Clin Oncol 119 1993 507 510
5. D.E. Swinson, G. Cox, and K.J. O'Byrne Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer Br J Cancer 4 2004 1301 1307
6. W. Pao, and V.A. Miller Epidermal growth factor receptor mutations, small molecule kinase inhibitors and non-small cell lung cancer: Current knowledge and future directions J Clin Oncol 23 2005 2556 2568
7. V. Grunwald, and M. Hidalgo Developing inhibitors of the epidermal growth factor receptor for cancer treatment J Natl Cancer Inst 95 2003 851 867
8. T.S. Mok, Y.L. Wu, and S. Thongprasert et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 2009 947 957
9. R. Rosell, T. Moran, and C. Queralt et al. Screening for epidermal growth factor receptor mutations in lung cancer N Engl J Med 361 2009 958 967
10. R. Pirker, J.R. Pereira, and A. Szczesna et al. Cetuximab plus chemotherapy in patients with advanced non-small cell lung cancer (FLEX): an open-label randomised phase III trial Lancet 373 2009 1525 1531
11. R. Baserga, A. Hongo, and M. Rubini et al. The IGF-1 receptor in cell growth, transformation and apoptosis Biochim Biophys Acta 1332 1997 F105 F126
12. V.A. Blakesley, B.S. Stannard, and T. Kalebic et al. Role of the IGF-1 receptor in mutagenesis and tumor promotion J Endocrinol 152 1997 339 344
13. H.M. Khandwala, I.E. McCutcheon, and A. Flyvbjerg et al. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth Endocr Rev 21 2000 215 244
14. D. LeRoith, and C.T. Roberts Jr. The insulin-like growth factor receptor system and cancer Cancer Lett 195 2003 127 137
15. Y.C. Lee, H.J. Jeon, and J.H. Kim et al. Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis Korean J Intern Med 23 2008 116 120
16. F. Cappuzzo, G. Tallini, and G. Finocchiaro et al. Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients Ann Oncol 21 2010 562 567
17. F. Cappuzzo, L. Toschi, and G. Tallini et al. Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib Ann Oncol 17 2006 1120 1127
18. R. Dziadziuszko, D.T. Merrick, and S.E. Witta et al. Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression J Clin Oncol 28 2010 2174 2180
19. M. Nakagawa, H. Uramoto, and S. Oka et al. Clinical significance of IGF1R expression in non-small cell lung cancer Clin Lung Cancer 13 2012 136 142
20. K. Gately, I. Collins, and L. Forde et al. A role for IGF1R targeted therapies in SCLC? Clin Lung Cancer 12 2011 38 42
21. F. Morgillo, J.K. Woo, and E.S. Kim et al. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib Cancer Res 66 2006 10100 10111
22. H.E. Jones, L. Goddard, and J.M. Gee et al. Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells Endocr Relat Cancer 11 2004 793 814
23. J. Riedemann, M. Takiguchi, M. Sohail, and V.M. Macaulay The EGF receptor interacts with the type 1 IGF receptor and regulates its stability Biochem Biophys Res Commun 355 2007 707 714
24. D. Coppola, A. Ferber, and M. Miura et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor Mol Cell Biol 14 1994 4588 4595
25. J. Riedemann, and V.M. Macaulay IGF1R signalling and its inhibition Endocr Relat Cancer 13 2006 S33 S43
26. D. Lu, H. Zhang, and H. Koo et al. A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity J Biol Chem 280 2005 19665 19672
27. J.P. Steinbach, C. Eisenmann, and A. Klumpp et al. Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis Biochem Biophys Res Commun 321 2004 524 530
28. L. Goetsch, A. Gonzalez, and O. Leger et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts Int J Cancer 113 2005 316 328
29. M. Guix, A.C. Faber, and S.E. Wang et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins J Clin Invest 118 2008 2609 2619
30. A.B. Cortot, C.E. Repellin, and T. Shimamura et al. Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway Cancer Res 73 2013 834 843
31. A. Camirand, M. Zakikhani, and F. Young et al. Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells Breast Cancer Res 7 2005 R570 R579
32. M.J. Fidler, S. Basu, and L. Buckingham et al. Utility of insulin-like growth factor receptor-1 expression in gefitinib treated patients with non-small cell lung cancer Anticancer Res 32 2012 1705 1710
33. V. Ludovini, G. Bellezza, and L. Pistola et al. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients Ann Onco 20 2009 842 849
34. V. Ludovini, A. Flacco, and F. Bianconi et al. Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients Cancer Chemother Pharmacol 71 2013 671 680
35. C.F. Mountain Revisions in the International System for Staging Lung Cancer Chest 111 1997 1710 1717
36. F.C. Detterbeck, D.J. Boffa, and L.T. Tanoue The new lung cancer staging system Chest 136 2009 260 271
37. R. Pirker, J.R. Pereira, and J. von Pawel et al. EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study Lancet Oncol 13 2012 33 42
38. C. Mascaux, M.W. Wynes, and Y. Kato et al. EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor - A novel antibody for immunohistochemistry or AQUA technology Clin Cancer Res 17 2011 7796 7807
39. R.I. Nicholson, J.M. Gee, and M.E. Harper EGFR and cancer prognosis Eur J Cancer 37 suppl 4 2001 S9 15
40. A.P. Meert, B. Martin, and P. Delmotte et al. The role of EGFR expression on patient survival in lung cancer: a systematic review with meta-analysis Eur Respir J 20 2002 975 981
41. R. Dziadziuszko, B. Holm, and B. Skov et al. Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small lung cancer patients treated with chemotherapy Ann Oncol 18 2007 447 452
42. D.T. Merrick, R. Dziadziuszko, and B. Szostakiewicz et al. High insulin-like growth factor1 receptor (IGF1R) expression is associated with poor survival in surgically treated non-small cell lung cancer (NSCLC) patients (pts) J Clin Oncol 2007 25:18(suppl):abstract 7550