HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosis via ERK/Ets-1 signalling pathway

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 11, 2014, Pages 2311-2320

  Wang, Wen Ke ^a   Lu, Qing Hua ^b   Zhang, Jia Ning ^c   Wang, Ben ^a   Liu, Xiang Juan ^a   An, Feng Shuang ^a   Qin, Wei Dong ^a   Chen, Xue Ying ^a   Dong, Wen Qian ^a   Zhang, Cheng ^a   Zhang, Yun ^a   Zhang, Ming Xiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocyte; Diabetes; Ets 1; High glucose; HMGB1

Indexed keywords

ETS1 PROTEIN, MOUSE; HIGH MOBILITY GROUP B1 PROTEIN; HMGB1 PROTEIN, MOUSE; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR ETS 1;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CARDIAC MUSCLE CELL; DIABETIC CARDIOMYOPATHY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HUMAN; HYPERGLYCEMIA; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; HMGB1 PROTEIN; HUMANS; HYPERGLYCEMIA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, INBRED NOD; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEIN C-ETS-1; SIGNAL TRANSDUCTION;

EID: 84911454382     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12399     Document Type: Article

References (44)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010; 87: 4-14.
2. Cai L, Kang YJ. Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc Toxicol. 2001; 1: 181-93.
3. Roberts AW, Clark AL, Witte KK. Review article: left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease-do we need to screen our patients? Diab Vasc Dis Res. 2009; 6: 153-63.
4. An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2006; 291: H1489-506.
5. Frustaci A, Kajstura J, Chimenti C, et al. Myocardial cell death in human diabetes. Circ Res. 2000; 87: 1123-32.
6. Falcao-Pires I, Leite-Moreira AF. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev. 2012; 17: 325-44.
7. Clarke M, Bennett M, Littlewood T. Cell death in the cardiovascular system. Heart. 2007; 93: 659-64.
8. Cai L, Li W, Wang G, et al. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002; 51: 1938-48.
9. Klune JR, Dhupar R, Cardinal J, et al. HMGB1: endogenous danger signaling. Mol Med. 2008; 14: 476-84.
10. Loukili N, Rosenblatt-Velin N, Li J, et al. Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. Cardiovasc Res. 2011; 89: 586-94.
11. Xie J, Mendez JD, Mendez-Valenzuela V, et al. Cellular signaling of the receptor for advanced glycation end products (RAGE). Cell Signal. 2013; 25: 2185-97.
12. Jenke A, Wilk S, Poller W, et al. Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury. Cardiovasc Res. 2013; 99: 422-31.
13. Yao Y, Xu X, Zhang G, et al. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic Res Cardiol. 2012; 107: 267.
14. Ding HS, Yang J, Chen P, et al. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. 2013; 527: 389-93.
15. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol. 2001; 2: 827-37.
16. Oikawa T, Yamada T. Molecular biology of the Ets family of transcription factors. Gene. 2003; 303: 11-34.
17. Gao Z, Kim GH, Mackinnon AC, et al. Ets1 is required for proper migration and differentiation of the cardiac neural crest. Development. 2010; 137: 1543-51.
18. Rottinger E, Besnardeau L, Lepage T. A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets. Development. 2004; 131: 1075-87.
19. Wang WK, Wang B, Lu QH, et al. Inhibition of high-mobility group box 1 improves myocardial fibrosis and dysfunction in diabetic cardiomyopathy. Int J Cardiol. 2014; 172: 202-12.
20. Liu L, Ding WY, Zhao J, et al. Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3. Int J Biochem Cell Biol. 2013; 45: 2027-35.
21. Ho FM, Liu SH, Liau CS, et al. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation. 2000; 101: 2618-24.
22. Li Y, Feng Q, Arnold M, et al. Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes. Cardiovasc Res. 2009; 84: 100-10.
23. Tzeng HP, Fan J, Vallejo JG, et al. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008; 294: H1490-6.
24. Teruyama K, Abe M, Nakano T, et al. Role of transcription factor Ets-1 in the apoptosis of human vascular endothelial cells. J Cell Physiol. 2001; 188: 243-52.
25. Awazu M, Ishikura K, Hida M, et al. Mechanisms of mitogen-activated protein kinase activation in experimental diabetes. J Am Soc Nephrol. 1999; 10: 738-45.
26. Qi H, Cao Y, Huang W, et al. Crucial role of calcium-sensing receptor activation in cardiac injury of diabetic rats. PLoS ONE. 2013; 8: e65147.
27. Callaway KA, Rainey MA, Riggs AF, et al. Properties and regulation of a transiently assembled ERK2.Ets-1 signaling complex. Biochemistry. 2006; 45: 13719-33.
28. Volz HC, Seidel C, Laohachewin D, et al. HMGB1: the missing link between diabetes mellitus and heart failure. Basic Res Cardiol. 2010; 105: 805-20.
29. Cai L, Kang YJ. Cell death and diabetic cardiomyopathy. Cardiovasc Toxicol. 2003; 3: 219-28.
30. Gustafsson AB, Gottlieb RA. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol. 2007; 292: C45-51.
31. Lee Y, Gustafsson AB. Role of apoptosis in cardiovascular disease. Apoptosis. 2009; 14: 536-48.
32. Baraka A, AbdelGawad H. Targeting apoptosis in the heart of streptozotocin-induced diabetic rats. J Cardiovasc Pharmacol Ther. 2010; 15: 175-81.
33. Zhai CL, Zhang MQ, Zhang Y, et al. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta Pharmacol Sin. 2012; 33: 1477-87.
34. Ding HS, Yang J, Chen P, et al. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. 2013; 527: 389-93.
35. Kang R, Zhang Q, Hou W, et al. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014; 146: 1097-107.
36. Tang D, Kang R, Cheh CW, et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. 2010; 29: 5299-310.
37. Penckofer S, Schwertz D, Florczak K. Oxidative stress and cardiovascular disease in type 2 diabetes: the role of antioxidants and pro-oxidants. J Cardiovasc Nurs. 2002; 16: 68-85.
38. Marra G, Cotroneo P, Pitocco D, et al. Early increase of oxidative stress and reduced antioxidant defenses in patients with uncomplicated type 1 diabetes: a case for gender difference. Diabetes Care. 2002; 25: 370-5.
39. Bai Y, Wang L, Li Y, et al. High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes. Cell Physiol Biochem. 2006; 17: 57-68.
40. Pei H, Li C, Adereth Y, et al. Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res. 2005; 65: 7205-13.
41. Ti Y, Xie GL, Wang ZH, et al. TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model. Diabetes. 2011; 60: 2963-74.
42. Schulman D, Latchman DS, Yellon DM. Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway. Am J Physiol Heart Circ Physiol. 2002; 283: H1481-8.
43. Xu W, Wu W, Chen J, et al. Exogenous hydrogen sulfide protects H9c2 cardiac cells against high glucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1/2 pathways. Int J Mol Med. 2013; 32: 917-25.
44. Sun KK, Ji C, Li X, et al. Overexpression of high mobility group protein B1 correlates with the proliferation and metastasis of lung adenocarcinoma cells. Mol Med Rep. 2013; 7: 1678-82.