Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells

Nutrition and Cancer

Volumn 66, Issue 8, 2014, Pages 1304-1314

  Le, Vy ^a   Esposito, Debora ^b   Grace, Mary H ^b   Ha, Danny ^a   Pham, Anh ^a   Bortolazzo, Anthony ^a   Bevens, Zackery ^a   Kim, John ^a   Okuda, Roy ^a   Komarnytsky, Slavko ^b   Lila, Mary Ann ^b   White, Joseph Brandon ^a  

^a SAN JOSE STATE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; ELLAGITANNIN; METHANOL; PHOSPHATIDYLSERINE; POLYPHENOL DERIVATIVE; CYTOCHROME C; PLANT EXTRACT; TANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; BIOENERGY; CANCER SIZE; CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL DEATH; CELL PH; CONTROLLED STUDY; CORONARY ARTERY DISEASE; COUNTER CURRENT CHROMATOGRAPHY; CYTOTOXICITY; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; JUGLANS CALIFORNICA; JUGLANS REGIA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; WALNUT; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; CHEMISTRY; DIET; DRUG EFFECTS; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; MITOCHONDRION; MOUSE; NUDE MOUSE; NUT; PH; TUMOR CELL LINE;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYCLIN B1; CYTOCHROMES C; DIET; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYZABLE TANNINS; JUGLANS; MCF-7 CELLS; MICE; MICE, NUDE; MITOCHONDRIA; NUTS; PLANT EXTRACTS;

EID: 84911418409     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2014.956246     Document Type: Article

References (34)

1. American Cancer Society: http://www.cancer.org/research/ cancerfactsstatistics/cancerfactsfigures2013/index
2. Lacroix M, Toillon RA, and Leclercq G: p53 and breast cancer, an update. Endocr Relat Cancer 13, 293-325, 2006.
3. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, et al.: Molecular portraits of human breast tumours. Nature 406, 747-752, 2000. doi: 10.1038/35021093
4. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, et al.: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proceedings of the National Academy of Sciences of the United States of America 98, 10869-10874, 2001. doi: 10.1073/ pnas.191367098
5. Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768-780, 2003.
6. Chen CY and Blumberg JB: Phytochemical composition of nuts. Asia Pacific Journal of Clinical Nutrition 17, 329-332, 2008.
7. Feldman EB: The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. Journal of Nutrition 132, 1062S-1101S, 2002.
8. Anderson KJ, Teuber SS, Gobeille A, Cremin P, Waterhouse AL, et al.: Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr 131, 2837-2842, 2001.
9. Hardman WE and Ion G: Suppression of implanted MDA-MB 231 Human breast cancer growth in nude mice by dietary walnut. Nutrition and Cancer 60, 666-674, 2008. doi: 10.1080/01635580802065302
10. Yang J, Liu RH, and Halim L: Antioxidant and antiproliferative activities of common edible nut seeds. LWT-Food Science and Technology 42, 1-8, 2009. doi: 10.1016/j.lwt.2008.07.007
11. Carvalho M, Ferreira PJ, Mendes VS, Silva R, Pereira JA, et al.: Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food and Chemical Toxicology 48, 441-447, 2010. doi: 10.1016/j. fct.2009.10.043
12. Grace MH, Warlick CW, Neff SA, and Lila MA: Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS. Food Chemistry 158, 229-238, 2014. doi: 10.1016/j.foodchem.2014.02.117
13. Mullen P: Flow cytometric DNA analysis of human cancer cell lines. Methods in Molecular Medicine 88, 247-255, 2004.
14. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685, 1970.
15. Chow S And Hedley D: Flow Cytometric Measurement Of Intracellular Ph. Current Protocols in Cytometry Unit 9.3, 2001. doi: 10.1002/ 0471142956.cy0903s14
16. Limer JL and Speirs V: Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Research 6, 119-127, 2004. doi: 10.1186/ Bcr781
17. Regueiro J, Sanchez-Gonzalez C, Vallverdu-Queralt A, Simal-Gandara J, Lamuela-Raventos R, et al.: Comprehensive identification of walnut polyphenols by liquid chromatography coupled to linear ion trap-Orbitrap mass spectrometry. Food Chemistry 152, 340-348, 2014. doi: 10.1016/j. foodchem.2013.11.158
18. Yadegarynia S, Pham A, Ng A, Nguyen D, Lialiutska T, et al.: Profiling flavonoid cytotoxicity in human breast cancer cell lines: determination of structure-function relationships. Natural Product Communications 7, 1295-1304, 2012.
19. Grana X and Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211-219, 1995.
20. Schutters K and Reutelingsperger C: Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis: An International Journal on Programmed Cell Death 15, 1072-1082, 2010. doi: 10.1007/ s10495-010-0503-y
21. Reers M, Smith TW, and Chen LB: J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 30, 4480-4486, 1991.
22. Tait SW and Green DR: Mitochondria and cell death: outer membrane permeabilization and beyond. Nature reviews Molecular cell biology 11, 621-632, 2010. doi: 10.1038/nrm2952
23. Lagadic-Gossmann D, Huc L, and Lecureur V: Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell death and differentiation 11, 953-961, 2004. doi: 10.1038/sj.cdd.4401466
24. Mehmet H, Millar JB, Lehmann W, Higgins T, and Rozengurt E: Bombesin stimulation of c-fos expression and mitogenesis in Swiss 3T3 cells: the role of prostaglandin E2-mediated cyclic AMP accumulation. Experimental Cell Research 190, 265-270, 1990.
25. Castano E, Dalmau M, Marti M, Berrocal F, Bartrons R, et al.: Inhibition of DNA synthesis by aspirin in Swiss 3T3 fibroblasts. The Journal of Pharmacology and Experimental Therapeutics 280, 366-372, 1997.
26. von Schwarzenberg K and Vollmar AM: Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy. Cancer Letters 332, 295-303, 2013. doi: 10.1016/j.canlet.2010.07.004
27. Saha SK and Khuda-Bukhsh AR: Molecular approaches towards development of purified natural products and their structurally known derivatives as efficient anti-cancer drugs: current trends. European Journal of Pharmacology 714, 239-248, 2013. doi: 10.1016/j.ejphar.2013.06.009
28. Cai Y, Luo Q, Sun M, and Corke H: Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sciences 74, 2157-84, 2004. doi: 10.1016/j. lfs.2003.09.047
29. Vanden Heuvel JP, Belda BJ, Hannon DB, Kris-Etherton PM, Grieger JA, et al.: Mechanistic examination of walnuts in prevention of breast cancer. Nutrition and Cancer 64, 1078-1086, 2012. doi: 10.1080/ 01635581.2012.717679
30. Miyamoto K, Nomura M, Murayama T, Furukawa T, Hatano T, et al.: Antitumor activities of ellagitannins against sarcoma-180 in mice. Biological & Pharmaceutical Bulletin 16, 379-387, 1993.
31. Yi ZC, Liu YZ, Li HX, Yin Y, Zhuang FY, et al.: Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Letters 242, 77-87, 2006. doi: 10.1016/j.canlet.2005.10.044
32. Landete JM: Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health. Food Research International 44, 1150-1160, 2011. doi: 10.1016/j.foodres.2011.04.027
33. Yamamoto Y and Gaynor RB: Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. The Journal of Clinical Investigation 107, 135-142, 2001. doi: 10.1172/ JCI11914
34. Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, et al.: Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochemical Pharmacology 69, 1421-1432, 2005. doi: 10.1016/j.bcp.2005.02.022