Identification of the pharmacophore of the CC chemokine-binding proteins evasin-1 and -4 using phage display

Journal of Biological Chemistry

Volumn 289, Issue 46, 2014, Pages 31846-31855

  Bonvin, Pauline ^a,b   Dunn, Steven M ^a   Rousseau, François ^a   Dyer, Douglas P ^c   Shaw, Jeffrey ^a   Power, Christine A ^a   Hel, Tracy M ^c   Proudfoot, Ama E I ^a,b  

^a MERCK SERONO S A   (Switzerland)

^b Novlmmune SA   (Switzerland)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; PHARMACODYNAMICS; SURFACE PLASMON RESONANCE;

BINDING PROTEINS; COMPLEX STRUCTURE; IN-SILICO MODELS; LIGAND-BINDING SURFACES; PURIFIED PROTEIN; RECEPTOR SIGNALING; RHIPICEPHALUS SANGUINEUS; SURFACE PLASMONS;

PROTEINS;

CHEMOKINE; EVASIN 1; EVASIN 4; GLUTAMINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 2; PHENYLALANINE; RANTES; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; ALANINE; BETA CHEMOKINE; CCL3 PROTEIN, HUMAN; CCL5 PROTEIN, HUMAN; CCL8 PROTEIN, HUMAN; CHEMOKINE RECEPTOR; EVASIN-1, RHIPICEPHALUS SANGUINEUS; LIGAND; PEPTIDE LIBRARY; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CHEMOTAXIS; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGAND BINDING; NONHUMAN; PHAGE DISPLAY; PHARMACOPHORE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; RHIPICEPHALUS SANGUINEUS; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE; ANIMAL; CELL MOTION; CHEMISTRY; GENETICS; GLYCOSYLATION; HEK293 CELL LINE; MOLECULAR GENETICS; PEPTIDE LIBRARY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CELL MOVEMENT; CHEMOKINE CCL3; CHEMOKINE CCL5; CHEMOKINE CCL8; CHEMOKINES, CC; CHEMOTAXIS; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; HEK293 CELLS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHEMOKINE; RHIPICEPHALUS SANGUINEUS; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE;

EID: 84911386825     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.599233     Document Type: Article

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