Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

Journal of Biological Chemistry

Volumn 289, Issue 47, 2014, Pages 32835-32844

  Krishnan, Shuba ^a   Paredes, João A ^a   Zhou, Xiaoshan ^a   Kuiper, Raoul V ^a   Hultenby, Kjell ^a   Curbo, Sophie ^a   Karlsson, Anna ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; DNA; ENZYMES; HISTOLOGY; LAKES; METABOLISM; NUCLEOTIDES; TISSUE;

CELL NUCLEUS; DROSOPHILA MELANOGASTER; FAT METABOLISM; LETHAL EFFECTS; MITOCHONDRIAL DNA; NUCLEOTIDE POOLS; THYMIDINE KINASE; TRANSGENE EXPRESSION;

MAMMALS;

COMPLEMENTARY DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MITOCHONDRIAL DNA; NUCLEOSIDASE; NUCLEOSIDE KINASE; THYMIDINE KINASE; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; NUCLEOSIDE PHOSPHOTRANSFERASE; NUCLEOTIDE; PHOSPHOTRANSFERASE; THYMIDINE KINASE 2;

ADIPOSE TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DNA SYNTHESIS; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; KIDNEY; LIFESPAN; LIPID METABOLISM; LIVER; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; TRANSGENE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; DEFICIENCY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTATION; SURVIVAL; TIME; TRANSGENIC MOUSE; ULTRASTRUCTURE;

DROSOPHILA MELANOGASTER; MUS;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; DNA, MITOCHONDRIAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; LIVER; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MUSCLE, SKELETAL; MUTATION; NUCLEOTIDES; PHOSPHOTRANSFERASES; SURVIVAL ANALYSIS; THYMIDINE KINASE; TIME FACTORS;

EID: 84911385529     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.588921     Document Type: Article

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