Early experiences: Building up the tools to face the challenges of adult life

Developmental Psychobiology

Volumn 56, Issue 8, 2014, Pages 1661-1674

  Branchi, Igor ^a,b   Cirulli, Francesca ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Animal model; Brain development; Communal nesting; Depression; Environment; Epigenetic; Handling; Maternal separation; Mental health; Non human primates; Risk factors; Rodents; Social; Stress

Indexed keywords

ANIMAL; ANIMAL MODEL; BRAIN; GROWTH, DEVELOPMENT AND AGING; MENTAL STRESS; METABOLISM; MOUSE; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; SOCIAL ENVIRONMENT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; MICE; MODELS, ANIMAL; SOCIAL ENVIRONMENT; STRESS, PSYCHOLOGICAL;

EID: 84911385269     PISSN: 00121630     EISSN: 10982302     Source Type: Journal    
DOI: 10.1002/dev.21235     Document Type: Review

References (126)

1. Aliaga, E. E., Mendoza, I., & Tapia-Arancibia, L. (2009). Distinct subcellular localization of BDNF transcripts in cultured hypothalamic neurons and modification by neuronal activation. Journal of Neural Transmission, 116(1), 23-32.
2. Baird, J., Osmond, C., MacGregor, A., Snieder, H., Hales, C. N., & Phillips, D. I. (2001). Testing the fetal origins hypothesis in twins: The Birmingham twin study. Diabetologia, 44(1), 33-39.
3. Baj, G., Leone, E., Chao, M. V., & Tongiorgi, E. (2011). Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16813-16818.
4. Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., et al. (2010). Early life programming and neurodevelopmental disorders. Biological Psychiatry, 68(4), 314-319.
5. Barker, D. J., Gluckman, P. D., Godfrey, K. M., Harding, J. E., et al. (1993). Fetal nutrition and cardiovascular disease in adult life. Lancet, 341(8850), 938-941.
6. Barker, D. J., Winter, P. D., Osmond, C., Margetts, B., & Simmonds, S. J. (1989). Weight in infancy and death from ischaemic heart disease. Lancet, 2(8663), 577-580.
7. Barr, C. S., Newman, T. K., Shannon, C., Parker, C., et al. (2004). Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry, 55(7), 733-738.
8. Barr, L. C., Heninger, G. R., Goodman, W., Charney, D. S., & Price, L. H. (1997). Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects. Biological Psychiatry, 41(9), 949-954.
9. Benediktsson, R., Calder, A. A., Edwards, C. R., & Seckl, J. R. (1997). Placental 11 beta-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure. Clinical Endocrinology (Oxford), 46(2), 161-166.
10. Berman, C. M., Rasmussen, K. L., & Suomi, S. J. (1997). Group size, infant development and social networks in free-ranging rhesus monkeys. Animal Behaviour, 53, 405-421.
11. Berry, A., & Cirulli, F. (2013). The p66(Shc) gene paves the way for healthspan: evolutionary and mechanistic perspectives. Neuroscience & Biobehavioral Reviews, 37(5), 790-802.
12. Berton, O., McClung, C. A., Dileone, R. J., Krishnan, V., et al. (2006). Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science, 311(5762), 864-868.
13. Bilbo, S. D., & Tsang, V. (2010). Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. The FASEB Journal, 24(6), 2104-2115.
14. Boersma, G. J., Moghadam, A. A., Cordner, Z. A., & Tamashiro, K. L. (2014). Prenatal stress and stress coping style interact to predict metabolic risk in male rats. Endocrinology, 155(4), 1302-1312.
15. Branchi, I. (2009). The mouse communal nest: Investigating the epigenetic influences of the early social environment on brain and behavior development. Neuroscience & Biobehavioral Reviews, 33(4), 551-559.
16. Branchi, I. (2011). The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology, 36(3), 339-351.
17. Branchi, I., & Alleva, E. (2006). Communal nesting, an early social enrichment, increases the adult anxiety-like response and shapes the role of social context in modulating the emotional behavior. Behavioural Brain Research, 172(2), 299-306.
18. Branchi, I., Curley, J. P., D'Andrea, I., Cirulli, F, Champagne, F. A., & Alleva, E. (2013). Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels. Psychoneuroendocrinology, 38(4), 522-532.
19. Branchi, I., D'Andrea, I., Cirulli, F., Lipp, H. P, et al. (2010). Shaping brain development: Mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome. Psychoneuroendocrinology, 35(5), 743-751.
20. Branchi, I., D'Andrea, I., Fiore, M., Di Fausto, V, et al. (2006). Early social enrichment shapes social behavior and nerve growth factor and brain-derived neurotrophic factor levels in the adult mouse brain. Biological Psychiatry, 60(7), 690-696.
21. Branchi, I., D'Andrea, I., Santarelli, S., Bonsignore, L. T, et al. (2011). The richness of social stimuli shapes developmental trajectories: Are laboratory mouse pups impoverished? Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(6), 1452-1460.
22. Branchi, I., D'Andrea, I., Sietzema, J., Fiore, M, et al. (2006). Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior. Journal of Neuroscience Research, 83(6), 965-973.
23. Branchi, I., Karpova, N. N., D'Andrea, I., Castren, E., et al. (2011). Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression. Neuroscience Letters, 495(3), 168-172.
24. Branchi, I., Santarelli, S., D'Andrea, I., & Alleva, E. (2013). Not all stressors are equal: Early social enrichment favors resilience to social but not physical stress in male mice. Hormones and Behavior, 63(3), 503-509.
25. Bullo, M., Peeraully, M. R., Trayhurn, P., Folch, J., et al. (2007). Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. European Journal of Endocrinology, 157(3), 303-310.
26. Caspi, A., & Moffitt, T. E. (2006). Gene-environment interactions in psychiatry: Joining forces with neuroscience. Nature Reviews Neuroscience, 7(7), 583-590.
27. Castren, E. (2005). Is mood chemistry? Nature Reviews Neuroscience, 6(3), 241-246.
28. Champagne, F. A. (2010). Epigenetic influence of social experiences across the lifespan. Developmental Psychobiology, 52(4), 299-311.
29. Chao, M. V., & Bothwell, M. (2002). Neurotrophins: To cleave or not to cleave. Neuron, 33(1), 9-12.
30. Chen, Z. Y., Jing, D., Bath, K. G., Ieraci, A, et al. (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science, 314(5796), 140-143.
31. Cirulli, F. (2001). Role of environmental factors on brain development and nerve growth factor expression. Physiology & Behavior, 73(3), 321-330.
32. Cirulli, F., & Alleva, E. (2009). The NGF saga: From animal models of psychosocial stress to stress-related psychopathology. Frontiers in Neuroendocrinology, 30(3), 379-395.
33. Cirulli, F., Alleva, E., Antonelli, A., & Aloe, L. (2000). NGF expression in the developing rat brain: Effects of maternal separation. Brain Research. Developmental Brain Research, 123, 129-134.
34. Cirulli, F., Berry, A., & Alleva, E. (2003). Early disruption of the mother-infant relationship: Effects on brain plasticity and implications for psychopathology. Neuroscience & Biobehavioral Reviews, 27(1-2), 73-82.
35. Cirulli, F., Berry, A., Bonsignore, L. T., Capone, F, et al. (2010). Early life influences on emotional reactivity: Evidence that social enrichment has greater effects than handling on anxiety-like behaviors, neuroendocrine responses to stress and central BDNF levels. Neuroscience & Biobehavioral Reviews, 34(6), 808-820.
36. Cirulli, F., Francia, N., Berry, A., Aloe, L., et al. (2009). Early life stress as a risk factor for mental health: Role of neurotrophins from rodents to non-human primates. Neuroscience & Biobehavioral Reviews, 33(4), 573-585.
37. Cirulli, F., Francia, N., Branchi, I., Antonucci, M. T., et al. (2009). Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques. Psychoneuroendocrinology, 34(2), 172-180.
38. Cirulli, F., Micera, A., Alleva, E., & Aloe, L. (1998). Early maternal separation increases NGF expression in the developing rat hippocampus. Pharmacology Biochemistry and Behavior, 59, 853-858.
39. Cirulli, F., Reif, A., Herterich, S., Lesch, K. P., et al. (2011). A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques. Psychoneuroendocrinology, 36(3), 372-379.
40. Cole, T. J., Blendy, J. A., Monaghan, A. P., Krieglstein, K., et al. (1995). Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes & Development, 9(13), 1608-1621.
41. Corripio, R., Gonzalez-Clemente, J. M., Jacobo, P. S., Silvia, N., et al. (2012). Plasma brain-derived neurotrophic factor in prepubertal obese children: Results from a 2-year lifestyle intervention programme. Clinical Endocrinology (Oxford), 77(5), 715-720.
42. Crowcroft, P., & Rowe, F. P. (1963). Social organization and territorial behavior in the wild house mice. Proceedings of the Zoological Society of London, 140, 517-531.
43. Curley, J. P., & Branchi, I. (2013). Ontogeny of stable individual differences: Gene-environment and epigenetic mechanisms. In D. Meastripieri & C. Carere (Eds.), Animal personalities: Behavior, physiology and evolution. Chicago: Chicago University Press.
44. Curley, J. P., Davidson, S., Bateson, P., & Champagne, F. A. (2009). Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice. Frontiers in Behavioral Neuroscience, 3, 25.
45. D'Andrea, I., Alleva, E., & Branchi, I. (2007). Communal nesting, an early social enrichment, affects social competences but not learning and memory abilities at adulthood. Behavioural Brain Research, 183(1), 60-66.
46. D'Andrea, I., Gracci, F., Alleva, E., & Branchi, I. (2010). Early social enrichment provided by communal nest increases resilience to depression-like behavior more in female than in male mice. Behavioural Brain Research, 215(1), 71-76.
47. Darnaudery, M., & Maccari, S. (2008). Epigenetic programming of the stress response in male and female rats by prenatal restraint stress. Brain Research Reviews, 57(2), 571-585.
48. de Waal, F. (1989). Peacemaking among primates. Cambridge, MA: Harvard University Press.
49. Deinhardt, K., & Chao, M. V. (2014). Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure. Neuropharmacology, 76(Pt C), 603-609.
50. Denenberg, V. H. (1964). Critical periods, stimulus input, and emotional reactivity: A theory of infantile stimulation. Psychological Review, 71, 335-351.
51. Duan, W., Guo, Z., Jiang, H., Ware, M., & Mattson, M. P. (2003). Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology, 144(6), 2446-2453.
52. Edwards, C. R., Benediktsson, R., Lindsay, R. S., & Seckl, J. R. (1993). Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension? Lancet, 341(8841), 355-357.
53. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112(2), 257-269.
54. El-Gharbawy, A. H., Adler-Wailes, D. C., Mirch, M. C., Theim, K. R., et al. (2006). Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab, 91(9), 3548-3552.
55. Entringer, S., Buss, C., Shirtcliff, E. A., Cammack, A. L, et al. (2010). Attenuation of maternal psychophysiological stress responses and the maternal cortisol awakening response over the course of human pregnancy. Stress, 13(3), 258-268.
56. Fantuzzo, J., Sekino, Y., & Cohen, H. L. (2004). An examination of the contributions of interactive peer play to salient classroom competencies for urban Head Start Children. Psychology in the Schools, 41(3), 323-336.
57. Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constancia, M., & Burton G. J. (2009). Placental efficiency and adaptation: Endocrine regulation. The Journal of Physiology, 587(Pt 14), 3459-3472.
58. Fox, E. A., & Byerly, M. S. (2004). A mechanism underlying mature-onset obesity: Evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 286(6), R994-R1004.
59. Gelfin, Y., Gorfine, M., & Lerer, B. (1998). Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers. The American Journal of Psychiatry, 155(2), 290-292.
60. Giachino, C., Canalia, N., Capone, F., Fasolo, A., et al. (2007). Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats. Neuroscience, 145(2), 568-578.
61. Gluckman, P. D., & Hanson, M. A. (2004). Developmental origins of disease paradigm: A mechanistic and evolutionary perspective. Pediatric Research, 56(3), 311-317.
62. Han, J. C., Liu, Q. R., Jones, M., Levinn, R. L., et al. (2008). Brain-derived neurotrophic factor and obesity in the WAGR syndrome. The New England Journal of Medicine, 359(9), 918-927.
63. Harlow, H. F. (1969). Agemate or peer affectional system. In D. S. Lehrman, R. A. Hinde, & E. Shaw (Eds.), Advances in the study of behavior. New York: Academic press.
64. Harris, A., & Seckl, J. (2011). Glucocorticoids, prenatal stress and the programming of disease. Hormones and Behavior, 59(3), 279-289.
65. Harris, J. R. (1998). The nurture assumption. New York: Free Press.
66. Heim, C., Bradley, B., Mletzko, T. C., Deveau, T. C., Musselman, D. L., Nemeroff, C. B., ... Binder, E. B. (2009). Effect of childhood trauma on adult depression and neuroendocrine function: Sex-specific moderation by CRH receptor 1 gene. Frontiers in Behavioral Neuroscience, 3: 41.
67. Henry, C., Kabbaj, M., Simon, H., Le Moal, M., & Maccari, S. (1994). Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. Journal of Neuroendocrinology, 6(3), 341-345.
68. Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., et al. (2006). The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. The Journal of Neuroscience, 26(14), 3840-3844.
69. Je, H. S., Yang, F., Ji, Y., Nagappan, G., et al. (2012). Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15924-15929.
70. Jiao, Y., Zhang, Z., Zhang, C., Wang, X., et al. (2011). A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12131-12136.
71. Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000). Effects of early adverse experiences on brain structure and function: Clinical implications. Biological Psychiatry, 48(8), 778-790.
72. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., et al. (2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59(8), 673-680.
73. Koizumi, H., Hashimoto, K., & Iyo, M. (2006). Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: Role of serotonergic system. European Journal of Neuroscience, 24(8), 2335-2344.
74. König, B. (1994). Fitness effects of communal rearing in house mice: The role of relatedness versus familiarity. Animal Behaviour, 48, 1449-1457.
75. Kotelevtsev, Y., Brown, R. W., Fleming, S., Kenyon, C., et al. (1999). Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. The Journal of Clinical Investigation, 103(5), 683-689.
76. Lang, U. E., Gunther, L., Scheuch, K., Klein, J., et al. (2009). Higher BDNF concentrations in the hippocampus and cortex of an aggressive mouse strain. Behavioural Brain Research, 197(1), 246-249.
77. Levine, R. S., Hennekens, C. H., & Jesse, M. J. (1994). Blood pressure in prospective population based cohort of newborn and infant twins. British Medical Journal, 308(6924), 298-302.
78. Levine, S. (2005). Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology, 30(10), 939-946.
79. Licinio, J., Dong, C., & Wong, M. L. (2009). Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Archives of General Psychiatry, 66(5), 488-497.
80. Lu, B., Pang, P. T., & Woo, N. H. (2005). The yin and yang of neurotrophin action. Nature Reviews Neuroscience, 6(8), 603-614.
81. Maccari, S., & Morley-Fletcher, S. (2007). Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations. Psychoneuroendocrinology, 32(Suppl. 1), S10-S15.
82. Maccari, S., Piazza, P. V., Kabbaj, M., Barbazanges, A., et al. (1995). Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. The Journal of Neuroscience, 15(1 Pt 1), 110-116.
83. Marosi, K., & Mattson, M. P. (2014). BDNF mediates adaptive brain and body responses to energetic challenges. Trends in Endocrinology & Metabolism, 25(2), 89-98.
84. McEwen, B. S., Brinton, R. E., & Sapolsky, R. M. (1988). Glucocorticoid receptors and behavior: Implications for the stress response. Advances in Experimental Medicine and Biology, 245, 35-45.
85. Meaney, M. J., Szyf, M., & Seckl, J. R. (2007). Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends in Molecular Medicine, 13(7), 269-277.
86. Mendl, M., & Paul, E. S. (1991). Litter composition affects parental care, offspring growth, and the development of aggressive behaviour in wild house mice. Behavior, 116, 11-41.
87. Meyer, J. S. (1983). Early adrenalectomy stimulates subsequent growth and development of the rat brain. Experimental Neurology, 82(2), 432-446.
88. Morley-Fletcher, S., Darnaudery, M., Koehl, M., Casolini, P., et al. (2003). Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine. Brain Research, 989(2), 246-251.
89. Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., et al. (2007). Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Neuropsychopharmacology, 32(7), 1504-1519.
90. Nousen, E. K., Franco, J. G., & Sullivan, E. L. (2013). Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders. Neuroendocrinology, 98(4), 254-266.
91. Osmond, C., Barker, D. J., Winter, P. D., Fall, C. H., C & Simmonds, S. J. (1993). Early growth and death from cardiovascular disease in women. British Medical Journal, 307(6918), 1519-1524.
92. Palanza, P. (2001). Animal models of anxiety and depression: How are females different? Neuroscience & Biobehavioral Reviews, 25(3), 219-233.
93. Pellegrini, A. D. (2008). The roles of aggressive and affiliative behaviors in resource control: A behavioral ecological perspective. Developmental Review, 28(4), 461-487.
94. Pham, T. M., Soderstrom, S., Henriksson, B. G., & Mohammed, A. H. (1997). Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor. Behavioural Brain Research, 86(1), 113-120.
95. Piaget, J. (1932). Moral judgment of the child. London: Kegan Paul.
96. Ribases, M., Gratacos, M., Fernandez-Aranda, F., Bellodi, L., et al. (2005). Association of BDNF with restricting anorexia nervosa and minimum body mass index: A family-based association study of eight European populations. European Journal of Human Genetics, 13(4), 428-434.
97. Rios, M., Fan, G., Fekete, C., Kelly, J., et al. (2001). Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Molecular Endocrinology, 15(10), 1748-1757.
98. Roceri, M., Cirulli, F., Pessina, C., Peretto, P., et al. (2004). Post-natal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Biological Psychiatry, 55(7), 708-714.
99. Ross, H. E., & Young, L. J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Frontiers in Neuroendocrinology, 30(4), 534-547.
100. Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009). Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry, 65(9), 760-769.
101. Roth, T. L., Matt, S., Chen, K., & Blaze, J. (2014). Bdnf DNA methylation modifications in the hippocampus and amygdala of male and female rats exposed to different caregiving environments outside the homecage. Developmental Psychobiology.
102. Sairanen, M., Lucas, G., Ernfors, P., Castren, M., & Castren, E. (2005). Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. The Journal of Neuroscience, 25(5), 1089-1094.
103. Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986). The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocrine Reviews, 7(3), 284-301.
104. Savitz, J., van der Merwe, L., Stein, D. J., Solms, M., & Ramesar, R. (2007). Genotype and childhood sexual trauma moderate neurocognitive performance: A possible role for brain-derived neurotrophic factor and apolipoprotein E variants. Biological Psychiatry, 62(5), 391-399.
105. Sayler A., & Salmon, M. (1969). Communal nursing in mice: Influence of multiple mothers on the growth of the young. Science, 164(885), 1309-1310.
106. Sayler, A., & Salmon, M. (1971). An ethological analysis of communal nursing by the house mouse (Mus musculus). Behavior, 40, 60-85.
107. Seckl, J. R. (1998). Physiologic programming of the fetus. Clinics in Perinatology, 25(4), 939-962, vii.
108. Sharma, S., & Fulton, S. (2012). Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. International Journal of Obesity (London), 37(3), 382-389.
109. Skledar, M., Nikolac, M., Dodig-Curkovic, K., Curkovic, M., et al. (2012). Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 36(1), 136-140.
110. Suomi, S. J. (1979). Peers, play and primary prevention in primates. In M. Kent & J. Rolf (Eds.), Primary prevention of psychopathology: Social competence in children (pp. 127-149). Hanover, NH: Press of New England.
111. Suwa, M., Kishimoto, H., Nofuji, Y., Nakano, H., et al. (2006). Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism, 55(7), 852-857.
112. Taylor, A. R., Gifondorwa, D. J., Robinson, M. B., Strupe, J. L., et al. (2012). Motoneuron programmed cell death in response to proBDNF. Developmental Neurobiology, 72(5), 699-712.
113. Thoenen, H. (1995). Neurotrophins and neuronal plasticity. Science, 270(5236), 593-598.
114. Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007). Epigenetic regulation in psychiatric disorders. Nature Reviews Neuroscience, 8(5), 355-367.
115. Vallee, M., Mayo, W., Dellu, F., Le Moal, M., et al. (1997). Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: Correlation with stress-induced corticosterone secretion. The Journal of Neuroscience, 17(7), 2626-2636.
116. Verhagen, M., van der Meij, A., van Deurzen, P. A., Janzing, J. G., et al. (2010). Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicity. Molecular Psychiatry, 15(3), 260-271.
117. Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., et al. (2012). Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior. Biological Psychiatry, 71(5), 419-426.
118. Ward, R. M. (1994). Pharmacologic enhancement of fetal lung maturation. Clinics in Perinatology, 21(3), 523-542.
119. Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847-854.
120. Wichers, M., Kenis, G., Jacobs, N., Mengelers, R., et al. (2008). The BDNF Val(66)Met×5-HTTLPR×child adversity interaction and depressive symptoms: An attempt at replication. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 120-123.
121. Yehuda, R., Fairman, K. R., & Meyer, J. S. (1989). Enhanced brain cell proliferation following early adrenalectomy in rats. Journal of Neurochemistry, 53(1), 241-248.
122. Zammit, S., Odd, D., Horwood, J., Thompson, A., et al. (2009). Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort. Psychological Medicine, 39(9), 1457-1467.
123. Zeltser, L. M., & Leibel, R. L. (2011). Roles of the placenta in fetal brain development. Proceedings of the National Academy of Sciences of the United States of America, 108(38), 15667-15668.
124. Zhang, L. X., Levine, S., Dent, G., Zhan, Y., et al. (2002). Maternal deprivation increases cell death in the infant rat brain. Brain Research. Developmental Brain Research, 133(1), 1-11.
125. Zhang, T. Y., & Meaney, M. J. (2010). Epigenetics and the environmental regulation of the genome and its function. Annual Review of Psychology, 61, 439-466, C431-C433.
126. Zubin, J., & Spring, B. (1977). Vulnerability-A new view of schizophrenia. Journal of Abnormal Psychology, 86(2), 103-126.