Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding

Journal of Biological Chemistry

Volumn 289, Issue 47, 2014, Pages 32682-32693

  Huang, Yiping ^a   Nokhrin, Sergiy ^b   Hassanzadeh Ghassabeh, Gholamreza ^c,d   Yu, Corey H ^b   Yang, Haojun ^a   Barry, Amanda N ^a   Tonelli, Marco ^e   Markley, John L ^e   Muyldermans, Serge ^c   Dmitriev, Oleg Y ^b   Lutsenko, Svetlana ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; COPPER; MOLECULAR DYNAMICS; STRUCTURAL DYNAMICS;

CELLULAR DYNAMICS; INTRACELLULAR COMPARTMENTS; INTRACELLULAR TARGETING; METAL BINDING DOMAIN; MULTIDOMAIN STRUCTURE; N-TERMINAL DOMAINS; RE-LOCALIZATION; SPATIAL ORGANIZATION;

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATASE; COPPER; MENKES PROTEIN; NANOBODY; WILSON DISEASE PROTEIN; CATION TRANSPORT PROTEIN; PHOTOPROTEIN; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; CELL MEMBRANE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METAL BINDING; MOLECULAR MECHANICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANS GOLGI NETWORK; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFOCAL MICROSCOPY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; NEW WORLD CAMELID; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CAMELIDS, NEW WORLD; CATION TRANSPORT PROTEINS; CELL MEMBRANE; COPPER; HEK293 CELLS; HUMANS; LUMINESCENT PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; SINGLE-DOMAIN ANTIBODIES;

EID: 84911363265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.580845     Document Type: Article

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